메뉴 건너뛰기




Volumn 136, Issue 7, 2009, Pages 1093-1104

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

Author keywords

BMP; Chondrogenesis; Growth plate; Mouse; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SONIC HEDGEHOG PROTEIN; FIBROBLAST GROWTH FACTOR; IHH PROTEIN, MOUSE; PARATHYROID HORMONE RELATED PROTEIN; SMAD1 PROTEIN, MOUSE; SMAD4 PROTEIN; SMAD4 PROTEIN, MOUSE; SMAD5 PROTEIN, MOUSE; SMAD9 PROTEIN, MOUSE;

EID: 66349117431     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.029926     Document Type: Article
Times cited : (304)

References (85)
  • 1
    • 33745958768 scopus 로고    scopus 로고
    • Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo
    • Arnold, S. J., Maretto, S., Islam, A., Bikoff, E. K. and Robertson, E. J. (2006). Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev. Biol. 296, 104-118.
    • (2006) Dev. Biol , vol.296 , pp. 104-118
    • Arnold, S.J.1    Maretto, S.2    Islam, A.3    Bikoff, E.K.4    Robertson, E.J.5
  • 3
    • 0031002675 scopus 로고    scopus 로고
    • Cloning and characterization of the promoter regions of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene: Analysis of deoxyribonucleic acid from normal subjects and patients with pseudohypoparathyroidism type 1b
    • Bettoun, J. D., Minagawa, M., Kwan, M. Y., Lee, H. S., Yasuda, T., Hendy, G. N., Goltzman, D. and White, J. H. (1997). Cloning and characterization of the promoter regions of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene: analysis of deoxyribonucleic acid from normal subjects and patients with pseudohypoparathyroidism type 1b. J. Clin. Endocrinol. Metab. 82, 1031-1040.
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 1031-1040
    • Bettoun, J.D.1    Minagawa, M.2    Kwan, M.Y.3    Lee, H.S.4    Yasuda, T.5    Hendy, G.N.6    Goltzman, D.7    White, J.H.8
  • 5
    • 8444245525 scopus 로고    scopus 로고
    • A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos
    • Brugger, S. M., Merrill, A. E., Torres-Vazquez, J., Wu, N., Ting, M. C., Cho, J. Y., Dobias, S. L., Yi, S. E., Lyons, K., Bell, J. R. et al. (2004). A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development 131, 5153-5165.
    • (2004) Development , vol.131 , pp. 5153-5165
    • Brugger, S.M.1    Merrill, A.E.2    Torres-Vazquez, J.3    Wu, N.4    Ting, M.C.5    Cho, J.Y.6    Dobias, S.L.7    Yi, S.E.8    Lyons, K.9    Bell, J.R.10
  • 6
    • 0032577276 scopus 로고    scopus 로고
    • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    • Brunet, L. J., McMahon, J. A., McMahon, A. P. and Harland, R. M. (1998). Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280, 1455-1457.
    • (1998) Science , vol.280 , pp. 1455-1457
    • Brunet, L.J.1    McMahon, J.A.2    McMahon, A.P.3    Harland, R.M.4
  • 7
    • 0035123060 scopus 로고    scopus 로고
    • The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization
    • Chacko, B. M., Qin, B., Correia, J. J., Lam, S. S., de Caestecker, M. P. and Lin, K. (2001). The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization. Nat. Struct. Biol. 8, 248-253.
    • (2001) Nat. Struct. Biol , vol.8 , pp. 248-253
    • Chacko, B.M.1    Qin, B.2    Correia, J.J.3    Lam, S.S.4    de Caestecker, M.P.5    Lin, K.6
  • 8
    • 0035263614 scopus 로고    scopus 로고
    • A Ser(365) ← Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia
    • Chen, L., Li, C., Qiao, W., Xu, X. and Deng, C. (2001). A Ser(365) ← Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Hum. Mol. Genet. 10, 457-465.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 457-465
    • Chen, L.1    Li, C.2    Qiao, W.3    Xu, X.4    Deng, C.5
  • 10
    • 4444249320 scopus 로고    scopus 로고
    • Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo
    • Chu, G. C., Dunn, N. R., Anderson, D. C., Oxburgh, L. and Robertson, E. J. (2004). Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131, 3501-3512.
    • (2004) Development , vol.131 , pp. 3501-3512
    • Chu, G.C.1    Dunn, N.R.2    Anderson, D.C.3    Oxburgh, L.4    Robertson, E.J.5
  • 11
    • 0032573058 scopus 로고    scopus 로고
    • The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation
    • Chung, U. I., Lanske, B., Lee, K., Li, E. and Kronenberg, H. (1998). The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc. Natl. Acad. Sci. USA 95, 13030-13035.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13030-13035
    • Chung, U.I.1    Lanske, B.2    Lee, K.3    Li, E.4    Kronenberg, H.5
  • 12
    • 0035135642 scopus 로고    scopus 로고
    • Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
    • Chung, U., Schipani, E., McMahon, A. P. and Kronenberg, H. M. (2001). Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J. Clin. Invest. 107, 295-304.
    • (2001) J. Clin. Invest , vol.107 , pp. 295-304
    • Chung, U.1    Schipani, E.2    McMahon, A.P.3    Kronenberg, H.M.4
  • 13
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis, B. N., Hilyard, A. C., Lagna, G. and Hata, A. (2008). SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454, 289-294.
    • (2008) Nature , vol.454 , pp. 289-294
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 14
    • 0344011648 scopus 로고    scopus 로고
    • Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes
    • Drissi, M. H., Li, X., Sheu, T. J., Zuscik, M. J., Schwarz, E. M., Puzas, J. E., Rosier, R. N. and O'Keefe, R. J. (2003). Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J. Cell. Biochem. 90, 1287-1298.
    • (2003) J. Cell. Biochem , vol.90 , pp. 1287-1298
    • Drissi, M.H.1    Li, X.2    Sheu, T.J.3    Zuscik, M.J.4    Schwarz, E.M.5    Puzas, J.E.6    Rosier, R.N.7    O'Keefe, R.J.8
  • 15
    • 17044365440 scopus 로고    scopus 로고
    • Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
    • Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M. and Piccolo, S. (2005). Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121, 87-99.
    • (2005) Cell , vol.121 , pp. 87-99
    • Dupont, S.1    Zacchigna, L.2    Cordenonsi, M.3    Soligo, S.4    Adorno, M.5    Rugge, M.6    Piccolo, S.7
  • 16
    • 0030200262 scopus 로고    scopus 로고
    • Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb
    • Duprez, D., Bell, E. J., Richardson, M. K., Archer, C. W., Wolpert, L., Brickell, P. M. and Francis-West, P. H. (1996). Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech. Dev. 57, 145-157.
    • (1996) Mech. Dev , vol.57 , pp. 145-157
    • Duprez, D.1    Bell, E.J.2    Richardson, M.K.3    Archer, C.W.4    Wolpert, L.5    Brickell, P.M.6    Francis-West, P.H.7
  • 17
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-β signaling through Smads
    • Feng, X.-H. and Derynck, R. (2005). Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693.
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 659-693
    • Feng, X.-H.1    Derynck, R.2
  • 18
    • 36248995245 scopus 로고    scopus 로고
    • Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    • Fuentealba, L. C., Eivers, E., Ikeda, A., Hurtado, C., Kuroda, H., Pera, E. M. and De Robertis, E. M. (2007). Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131, 980-993.
    • (2007) Cell , vol.131 , pp. 980-993
    • Fuentealba, L.C.1    Eivers, E.2    Ikeda, A.3    Hurtado, C.4    Kuroda, H.5    Pera, E.M.6    De Robertis, E.M.7
  • 21
    • 0036696005 scopus 로고    scopus 로고
    • The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C
    • Guo, J., Chung, U. I., Kondo, H., Bringhurst, F. R. and Kronenberg, H. M. (2002). The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev. Cell 3, 183-194.
    • (2002) Dev. Cell , vol.3 , pp. 183-194
    • Guo, J.1    Chung, U.I.2    Kondo, H.3    Bringhurst, F.R.4    Kronenberg, H.M.5
  • 23
    • 0033024513 scopus 로고    scopus 로고
    • Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function
    • Haas, A. R. and Tuan, R. S. (1999). Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function. Differentiation 64, 77-89.
    • (1999) Differentiation , vol.64 , pp. 77-89
    • Haas, A.R.1    Tuan, R.S.2
  • 24
    • 4644358680 scopus 로고    scopus 로고
    • Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis
    • Hatakeyama, Y., Tuan, R. S. and Shum, L. (2004). Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis. J. Cell. Biochem. 91, 1204-1217.
    • (2004) J. Cell. Biochem , vol.91 , pp. 1204-1217
    • Hatakeyama, Y.1    Tuan, R.S.2    Shum, L.3
  • 25
    • 33646876973 scopus 로고    scopus 로고
    • Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
    • He, W., Dorn, D. C., Erdjument-Bromage, H., Tempst, P., Moore, M. A. and Massague, J. (2006). Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 125, 929-941.
    • (2006) Cell , vol.125 , pp. 929-941
    • He, W.1    Dorn, D.C.2    Erdjument-Bromage, H.3    Tempst, P.4    Moore, M.A.5    Massague, J.6
  • 26
    • 22844440947 scopus 로고    scopus 로고
    • Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors
    • Hoffmann, A., Preobrazhenska, O., Wodarczyk, C., Medler, Y., Winkel, A., Shahab, S., Huylebroeck, D., Gross, G. and Verschueren, K. (2005). Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors. J. Biol. Chem. 280, 27271-27283.
    • (2005) J. Biol. Chem , vol.280 , pp. 27271-27283
    • Hoffmann, A.1    Preobrazhenska, O.2    Wodarczyk, C.3    Medler, Y.4    Winkel, A.5    Shahab, S.6    Huylebroeck, D.7    Gross, G.8    Verschueren, K.9
  • 29
    • 0034625342 scopus 로고    scopus 로고
    • BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
    • Kimura, N., Matsuo, R., Shibuya, H., Nakashima, K. and Taga, T. (2000). BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J. Biol. Chem. 275, 17647-17652.
    • (2000) J. Biol. Chem , vol.275 , pp. 17647-17652
    • Kimura, N.1    Matsuo, R.2    Shibuya, H.3    Nakashima, K.4    Taga, T.5
  • 31
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
    • Kretzschmar, M., Doody, J. and Massague, J. (1997). Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389, 618-622.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massague, J.3
  • 32
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H. M. (2003). Developmental regulation of the growth plate. Nature 423, 332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 34
    • 0032717355 scopus 로고    scopus 로고
    • Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
    • Lanske, B., Amling, M., Neff, L., Guiducci, J., Baron, R. and Kronenberg, H. M. (1999). Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J. Clin. Invest. 104, 399-407.
    • (1999) J. Clin. Invest , vol.104 , pp. 399-407
    • Lanske, B.1    Amling, M.2    Neff, L.3    Guiducci, J.4    Baron, R.5    Kronenberg, H.M.6
  • 36
    • 0028071586 scopus 로고
    • Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice
    • Lefebvre, V., Garofalo, S., Zhou, G., Metsaranta, M., Vuorio, E. and De Crombrugghe, B. (1994). Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice. Matrix Biol. 14, 329-335.
    • (1994) Matrix Biol , vol.14 , pp. 329-335
    • Lefebvre, V.1    Garofalo, S.2    Zhou, G.3    Metsaranta, M.4    Vuorio, E.5    De Crombrugghe, B.6
  • 37
    • 0030899814 scopus 로고    scopus 로고
    • SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene
    • Lefebvre, V., Huang, W., Harley, V. R., Goodfellow, P. N. and de Crombrugghe, B. (1997). SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol. Cell. Biol. 17, 2336-2346.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 2336-2346
    • Lefebvre, V.1    Huang, W.2    Harley, V.R.3    Goodfellow, P.N.4    de Crombrugghe, B.5
  • 38
    • 0942268156 scopus 로고    scopus 로고
    • Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias
    • Legeai-Mallet, L., Benoist-Lasselin, C., Munnich, A. and Bonaventure, J. (2004). Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias. Bone 34, 26-36.
    • (2004) Bone , vol.34 , pp. 26-36
    • Legeai-Mallet, L.1    Benoist-Lasselin, C.2    Munnich, A.3    Bonaventure, J.4
  • 39
    • 0029620653 scopus 로고
    • Gene structure of chick cartilage chondroitin sulfate proteoglycan (aggrecan) core protein
    • Li, H. and Schwartz, N. B. (1995). Gene structure of chick cartilage chondroitin sulfate proteoglycan (aggrecan) core protein. J. Mol. Evol. 41, 878-885.
    • (1995) J. Mol. Evol , vol.41 , pp. 878-885
    • Li, H.1    Schwartz, N.B.2
  • 40
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
    • Liu, F., Pouponnot, C. and Massague, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11, 3157-3167.
    • (1997) Genes Dev , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massague, J.3
  • 42
    • 15944422208 scopus 로고    scopus 로고
    • Localization of Indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone development
    • MacLean, H. E. and Kronenberg, H. M. (2005). Localization of Indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone development. Dev. Growth Differ. 47, 59-63.
    • (2005) Dev. Growth Differ , vol.47 , pp. 59-63
    • MacLean, H.E.1    Kronenberg, H.M.2
  • 44
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • Massague, J., Seoane, J. and Wotton, D. (2005). Smad transcription factors. Genes Dev. 19, 2783-2810.
    • (2005) Genes Dev , vol.19 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 45
    • 0029074185 scopus 로고
    • Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters
    • McCuaig, K. A., Lee, H. S., Clarke, J. C., Assar, H., Horsford, J. and White, J. H. (1995). Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters. Nucleic Acids Res. 23, 1948-1955.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1948-1955
    • McCuaig, K.A.1    Lee, H.S.2    Clarke, J.C.3    Assar, H.4    Horsford, J.5    White, J.H.6
  • 46
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina, E., Wenzel, H. M., Kreschel, C., Karp, S., Gaffield, W., McMahon, A. P. and Vortkamp, A. (2001). BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 128, 4523-4534.
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 47
    • 0036744820 scopus 로고    scopus 로고
    • Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
    • Minina, E., Kreschel, C., Naski, M. C., Ornitz, D. M. and Vortkamp, A. (2002). Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev. Cell 3, 439-449.
    • (2002) Dev. Cell , vol.3 , pp. 439-449
    • Minina, E.1    Kreschel, C.2    Naski, M.C.3    Ornitz, D.M.4    Vortkamp, A.5
  • 48
    • 29244452110 scopus 로고    scopus 로고
    • Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification
    • Minina, E., Schneider, S., Rosowski, M., Lauster, R. and Vortkamp, A. (2005). Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr. Patterns 6, 102-109.
    • (2005) Gene Expr. Patterns , vol.6 , pp. 102-109
    • Minina, E.1    Schneider, S.2    Rosowski, M.3    Lauster, R.4    Vortkamp, A.5
  • 49
    • 1042289662 scopus 로고    scopus 로고
    • Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype
    • Murakami, S., Balmes, G., McKinney, S., Zhang, Z., Givol, D. and de Crombrugghe, B. (2004). Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev. 18, 290-305.
    • (2004) Genes Dev , vol.18 , pp. 290-305
    • Murakami, S.1    Balmes, G.2    McKinney, S.3    Zhang, Z.4    Givol, D.5    de Crombrugghe, B.6
  • 50
    • 0032413011 scopus 로고    scopus 로고
    • Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
    • Naski, M. C., Colvin, J. S., Coffin, J. D. and Ornitz, D. M. (1998). Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 125, 4977-4988.
    • (1998) Development , vol.125 , pp. 4977-4988
    • Naski, M.C.1    Colvin, J.S.2    Coffin, J.D.3    Ornitz, D.M.4
  • 51
    • 18144391965 scopus 로고    scopus 로고
    • FGF signaling in the developing endochondral skeleton
    • Ornitz, D. M. (2005). FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev. 16, 205-213.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 205-213
    • Ornitz, D.M.1
  • 52
    • 12944265540 scopus 로고    scopus 로고
    • Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice
    • Ovchinnikov, D. A., Deng, J. M., Ogunrinu, G. and Behringer, R. R. (2000). Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 26, 145-146.
    • (2000) Genesis , vol.26 , pp. 145-146
    • Ovchinnikov, D.A.1    Deng, J.M.2    Ogunrinu, G.3    Behringer, R.R.4
  • 53
    • 0034194023 scopus 로고    scopus 로고
    • PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes
    • Pateder, D. B., Rosier, R. N., Schwarz, E. M., Reynolds, P. R., Puzas, J. E., D'Souza, M. and O'Keefe, R. J. (2000). PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes. Exp. Cell Res. 256, 555-562.
    • (2000) Exp. Cell Res , vol.256 , pp. 555-562
    • Pateder, D.B.1    Rosier, R.N.2    Schwarz, E.M.3    Reynolds, P.R.4    Puzas, J.E.5    D'Souza, M.6    O'Keefe, R.J.7
  • 54
    • 0033562850 scopus 로고    scopus 로고
    • Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation
    • Pathi, S., Rutenberg, J. B., Johnson, R. L. and Vortkamp, A. (1999). Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Dev. Biol. 209, 239-253.
    • (1999) Dev. Biol , vol.209 , pp. 239-253
    • Pathi, S.1    Rutenberg, J.B.2    Johnson, R.L.3    Vortkamp, A.4
  • 55
    • 0346594337 scopus 로고    scopus 로고
    • Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera, E. M., Ikeda, A., Eivers, E. and De Robertis, E. M. (2003). Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev. 17, 3023-3028.
    • (2003) Genes Dev , vol.17 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2    Eivers, E.3    De Robertis, E.M.4
  • 56
    • 20444436749 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling
    • Qiao, B., Padilla, S. R. and Benya, P. D. (2005). Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling. J. Biol. Chem. 280, 17562-17571.
    • (2005) J. Biol. Chem , vol.280 , pp. 17562-17571
    • Qiao, B.1    Padilla, S.R.2    Benya, P.D.3
  • 57
    • 0347717892 scopus 로고    scopus 로고
    • Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes
    • Raucci, A., Laplantine, E., Mansukhani, A. and Basilico, C. (2004). Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes. J. Biol. Chem. 279, 1747-1756.
    • (2004) J. Biol. Chem , vol.279 , pp. 1747-1756
    • Raucci, A.1    Laplantine, E.2    Mansukhani, A.3    Basilico, C.4
  • 58
    • 24644495295 scopus 로고    scopus 로고
    • Reilly, G. C., Golden, E. B., Grasso-Knight, G. and Leboy, P. S. (2005). Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes. Cell Commun. Signal. 3, 3.
    • Reilly, G. C., Golden, E. B., Grasso-Knight, G. and Leboy, P. S. (2005). Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes. Cell Commun. Signal. 3, 3.
  • 59
    • 69549134963 scopus 로고    scopus 로고
    • Retting, K. N. and Lyons, K. M. (2006). BMP signaling and the regulation of endochondral bone formation. Cell Sci. Rev. 3, 67-88.
    • Retting, K. N. and Lyons, K. M. (2006). BMP signaling and the regulation of endochondral bone formation. Cell Sci. Rev. 3, 67-88.
  • 60
    • 39049121312 scopus 로고    scopus 로고
    • How the Smads regulate transcription
    • Ross, S. and Hill, C. S. (2008). How the Smads regulate transcription. Int. J. Biochem. Cell Biol. 30, 383-408.
    • (2008) Int. J. Biochem. Cell Biol , vol.30 , pp. 383-408
    • Ross, S.1    Hill, C.S.2
  • 61
    • 0033151612 scopus 로고    scopus 로고
    • FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
    • Sahni, M., Ambrosetti, D. C., Mansukhani, A., Gertner, R., Levy, D. and Basilico, C. (1999). FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev. 13, 1361-1366.
    • (1999) Genes Dev , vol.13 , pp. 1361-1366
    • Sahni, M.1    Ambrosetti, D.C.2    Mansukhani, A.3    Gertner, R.4    Levy, D.5    Basilico, C.6
  • 62
    • 0034960254 scopus 로고    scopus 로고
    • STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    • Sahni, M., Raz, R., Coffin, J. D., Levy, D. and Basilico, C. (2001). STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128, 2119-2129.
    • (2001) Development , vol.128 , pp. 2119-2129
    • Sahni, M.1    Raz, R.2    Coffin, J.D.3    Levy, D.4    Basilico, C.5
  • 63
    • 33846688094 scopus 로고    scopus 로고
    • Balancing BMP signaling through integrated inputs into the Smad1 linker
    • Sapkota, G., Alarcon, C., Spagnoli, F. M., Brivanlou, A. H. and Massague, J. (2007). Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol. Cell 25, 441-454.
    • (2007) Mol. Cell , vol.25 , pp. 441-454
    • Sapkota, G.1    Alarcon, C.2    Spagnoli, F.M.3    Brivanlou, A.H.4    Massague, J.5
  • 64
    • 2442622480 scopus 로고    scopus 로고
    • Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway
    • Seki, K. and Hata, A. (2004). Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. J. Biol. Chem. 279, 18544-18549.
    • (2004) J. Biol. Chem , vol.279 , pp. 18544-18549
    • Seki, K.1    Hata, A.2
  • 65
    • 0034598964 scopus 로고    scopus 로고
    • Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells
    • Shukunami, C., Akiyama, H., Nakamura, T. and Hiraki, Y. (2000). Requirement of autocrine signaling by bone morphogenetic protein-4 for chondrogenic differentiation of ATDC5 cells. FEBS Lett. 469, 83-87.
    • (2000) FEBS Lett , vol.469 , pp. 83-87
    • Shukunami, C.1    Akiyama, H.2    Nakamura, T.3    Hiraki, Y.4
  • 66
    • 0034695483 scopus 로고    scopus 로고
    • Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling
    • Sirard, C., Kim, S., Mirtsos, C., Tadich, P., Hoodless, P. A., Itié, A., Maxson, R., Wrana, J. L. and Mak, T. W. (2000). Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. J. Biol. Chem. 275, 2063-2070.
    • (2000) J. Biol. Chem , vol.275 , pp. 2063-2070
    • Sirard, C.1    Kim, S.2    Mirtsos, C.3    Tadich, P.4    Hoodless, P.A.5    Itié, A.6    Maxson, R.7    Wrana, J.L.8    Mak, T.W.9
  • 68
    • 34247118840 scopus 로고    scopus 로고
    • Development of the post-natal growth plate requires intraflagellar transport proteins
    • Song, B., Haycraft, C. J., Seo, H. S., Yoder, B. K. and Serra, R. (2007). Development of the post-natal growth plate requires intraflagellar transport proteins. Dev. Biol. 305, 22-16.
    • (2007) Dev. Biol , vol.305 , pp. 22-16
    • Song, B.1    Haycraft, C.J.2    Seo, H.S.3    Yoder, B.K.4    Serra, R.5
  • 69
    • 1542314840 scopus 로고    scopus 로고
    • p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation
    • Stanton, L. A., Sabari, S., Sampaio, A. V., Underhill, T. M. and Beier, F. (2004). p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. Biochem. J. 378, 53-62.
    • (2004) Biochem. J , vol.378 , pp. 53-62
    • Stanton, L.A.1    Sabari, S.2    Sampaio, A.V.3    Underhill, T.M.4    Beier, F.5
  • 70
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St Jacques, B., Hammerschmidt, M. and McMahon, A. P. (1999). Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13, 2072-2086.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 71
    • 3442894138 scopus 로고    scopus 로고
    • Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype
    • Subramanian, G., Schwarz, R. E., Higgins, L., McEnroe, G., Chakravarty, S., Dugar, S. and Reiss, M. (2004). Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype. Cancer Res. 64, 5200-5211.
    • (2004) Cancer Res , vol.64 , pp. 5200-5211
    • Subramanian, G.1    Schwarz, R.E.2    Higgins, L.3    McEnroe, G.4    Chakravarty, S.5    Dugar, S.6    Reiss, M.7
  • 74
    • 0141884395 scopus 로고    scopus 로고
    • Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse
    • Umans, L., Vermeire, L., Francis, A., Chang, H., Huylebroeck, D. and Zwijsen, A. (2003). Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse. Genesis 37, 5-11.
    • (2003) Genesis , vol.37 , pp. 5-11
    • Umans, L.1    Vermeire, L.2    Francis, A.3    Chang, H.4    Huylebroeck, D.5    Zwijsen, A.6
  • 75
    • 0037072760 scopus 로고    scopus 로고
    • Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes
    • Valcourt, U., Gouttenoire, J., Moustakas, A., Herbage, D. and Mallein-Gerin, F. (2002). Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes. J. Biol. Chem. 277, 33545-33558.
    • (2002) J. Biol. Chem , vol.277 , pp. 33545-33558
    • Valcourt, U.1    Gouttenoire, J.2    Moustakas, A.3    Herbage, D.4    Mallein-Gerin, F.5
  • 76
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 663-666.
    • (1996) Science , vol.273 , pp. 663-666
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.6
  • 77
    • 0032931819 scopus 로고    scopus 로고
    • Mice lacking link protein develop dwarfism and craniofacial abnormalities
    • Watanabe, H. and Yamada, Y. (1999). Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nat. Genet. 21, 225-229.
    • (1999) Nat. Genet , vol.21 , pp. 225-229
    • Watanabe, H.1    Yamada, Y.2
  • 78
    • 25844486925 scopus 로고    scopus 로고
    • Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse
    • Wijgerde, M., Karp, S., McMahon, J. and McMahon, A. P. (2005). Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse. Dev. Biol. 286, 149-157.
    • (2005) Dev. Biol , vol.286 , pp. 149-157
    • Wijgerde, M.1    Karp, S.2    McMahon, J.3    McMahon, A.P.4
  • 80
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
    • Wu, R. Y., Zhang, Y., Feng, X. H. and Derynck, R. (1997). Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17, 2521-2528.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 2521-2528
    • Wu, R.Y.1    Zhang, Y.2    Feng, X.H.3    Derynck, R.4
  • 81
    • 13444296903 scopus 로고    scopus 로고
    • Multiple functions of BMPs in chondrogenesis
    • Yoon, B. S. and Lyons, K. M. (2004). Multiple functions of BMPs in chondrogenesis. J. Cell. Biochem. 93, 93-103.
    • (2004) J. Cell. Biochem , vol.93 , pp. 93-103
    • Yoon, B.S.1    Lyons, K.M.2
  • 83
    • 33846067098 scopus 로고    scopus 로고
    • BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways
    • Yoon, B. S., Pogue, R., Ovchinnikov, D. A., Yoshii, I., Mishina, Y., Behringer, R. R. and Lyons, K. M. (2006). BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development 133, 4667-4678.
    • (2006) Development , vol.133 , pp. 4667-4678
    • Yoon, B.S.1    Pogue, R.2    Ovchinnikov, D.A.3    Yoshii, I.4    Mishina, Y.5    Behringer, R.R.6    Lyons, K.M.7
  • 84
    • 11144354938 scopus 로고    scopus 로고
    • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    • Yoshida, C. A., Yamamoto, H., Fujita, T., Furuichi, T., Ito, K., Inoue, K., Yamana, K., Zanma, A., Takada, K., Ito, Y. et al. (2004). Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 18, 952-963.
    • (2004) Genes Dev , vol.18 , pp. 952-963
    • Yoshida, C.A.1    Yamamoto, H.2    Fujita, T.3    Furuichi, T.4    Ito, K.5    Inoue, K.6    Yamana, K.7    Zanma, A.8    Takada, K.9    Ito, Y.10
  • 85
    • 23944485929 scopus 로고    scopus 로고
    • Smad4 is required for the normal organization of the cartilage growth plate
    • Zhang, J., Tan, X., Li, W., Wang, Y., Wang, J., Cheng, X. and Yang, X. (2005). Smad4 is required for the normal organization of the cartilage growth plate. Dev. Biol. 284, 311-322.
    • (2005) Dev. Biol , vol.284 , pp. 311-322
    • Zhang, J.1    Tan, X.2    Li, W.3    Wang, Y.4    Wang, J.5    Cheng, X.6    Yang, X.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.