Differential display analysis of presenilin 1-deficient mouse brains

Molecular Brain Research

Volumn 109, Issue 1-2, 2002, Pages 56-62

  Liauw, Jennifer ^a,b   Nguyen, Van ^a,b   Huang, Jean ^a,b   St George Hyslop, Peter ^a,b   Rozmahel, Richard ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Alzheimer's disease; Cell division cycle 10 (CDC10); Delta catenin; Differential display; Hypoxia inducible factor 1 alpha subunit (Hif1a); Mouse models; Neuronal plakophilin related armadillo protein (NPRAP); Notch signaling; Presenilin; Septin

Indexed keywords

CATENIN; CELL CYCLE PROTEIN; COMPLEMENTARY DNA; HYPOXIA INDUCIBLE FACTOR 1; MUTANT PROTEIN; NUCLEOSIDE DIPHOSPHATE KINASE; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL DISPLAY; DISEASE MODEL; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN FUNCTION; SIBLING;

ALZHEIMER DISEASE; ANIMALS; BRAIN; FEMALE; GENE EXPRESSION PROFILING; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PRESENILIN-1;

ARMADILLO;

EID: 0037203240     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(02)00491-6     Document Type: Article

References (59)

1. Adams C.L., Nelson W.J. Cytomechanics of cadherin-mediated cell-cell adhesion. Curr. Opin. Cell Biol. 10:1998;572-577.
2. Anderton B.H., Dayanandan R., Killick R., Lovestone S. Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease? Mol. Med. Today. 6:2000;54-59.
3. Axelrod J.D., Matsuno K., Artavanis-Tsakonas S., Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science. 271:1996;1826-1832.
4. Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., Slunt H.H., Wang R., Seeger M., Levey A.I., Gandy S.E., Copeland N.G., Jenkins N.A., Price D.L., Younkin S.G., Sisodia S.S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
5. Burgess R., Rawls A., Brown D., Bradley A., Olson E.N. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature. 384:1996;570-573.
6. F. Chen, Y. Gu, H. Hasegawa, X. Ruan, S. Arawaka, P. Fraser, D. Westaway, H. Mount, P. St. George-Hyslop, Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of APP and S3-cleavage of notch, J. Biol. Chem. (2002) in press.
7. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St George Hyslop P., Selkoe D.J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nature Med. 3:1997;67-72.
8. Conlon R.A., Reaume A.G., Rossant J. Notch1 is required for the coordinate segmentation of somites. Development. 121:1995;1533-1545.
9. De Ferrari G.V., Inestrosa N.C. Wnt signaling function in Alzheimer's disease. Brain Res. Rev. 33:2000;1-12.
10. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522.
11. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Annaert W., Von Figura K., Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391:1998;387-390.
12. Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M.N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
13. Field C.M., Kellogg D. Septins: cytoskeletal polymers or signalling GTPases? Trends Cell Biol. 9:1999;387-394.
14. Georgakopoulos A., Marambaud P., Efthimiopoulos S., Shioi J., Cui W., Li H.C., Schutte M., Gordon R., Holstein G.R., Martinelli G., Mehta P., Friedrich V.L. Jr., Robakis N.K. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol. Cell. 4:1999;893-902.
15. Gervasi F., D'Agnano I., Vossio S., Zupi G., Sacchi A., Lombardi D. nm23 influences proliferation and differentiation of PC12 cells in response to nerve growth factor. Cell Growth Differ. 7:1996;1689-1695.
16. Guo Q., Fu W., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., Mattson M.P. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nature Med. 5:1999;101-106.
17. Hrabe de Angelis M., McIntyre J., Gossler A. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature. 386:1997;717-721.
18. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12:1998;149-162.
19. 2 tension. Am. J. Physiol. 271:1996;C1172-1180.
20. Kang D.E., Soriano S., Frosch M.P., Collins T., Naruse S., Sisodia S.S., Leibowitz G., Levine F., Koo E.H. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J. Neurosci. 19:1999;4229-4237.
21. Kartmann B., Roth D. Novel roles for mammalian septins: from vesicle trafficking to oncogenesis. J. Cell Sci. 114:2001;839-844.
22. Kinoshita A., Kinoshita M., Akiyama H., Tomimoto H., Akiguchi I., Kumar S., Noda M., Kimura J. Identification of septins in neurofibrillary tangles in Alzheimer's disease. Am. J. Pathol. 153:1998;1551-1560.
23. Kotch L.E., Iyer N.V., Laughner E., Semenza G.L. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 209:1999;254-267.
24. Kudo T., Imaizumi K., Tanimukai H., Katayama T., Sato N., Nakamura Y., Tanaka T., Kashiwagi Y., Jinno Y., Tohyama M., Takeda M. Are cerebrovascular factors involved in Alzheimer's disease? Neurobiol. Aging. 21:2000;215-224.
25. Kusumi K., Sun E.S., Kerrebrock A.W., Bronson R.T., Chi D.C., Bulotsky M.S., Spencer J.B., Birren B.W., Frankel W.N., Lander E.S. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nature Genet. 19:1998;274-278.
26. Lakso M., Steeg P.S., Westphal H. Embryonic expression of nm23 during mouse organogenesis. Cell Growth Differ. 3:1992;873-879.
27. Levesque G., Yu G., Nishimura M., Zhang D.M., Levesque L., Yu H., Xu D., Liang Y., Rogaeva E., Ikeda M., Duthie M., Murgolo N., Wang L., VanderVere P., Bayne M.L., Strader C.D., Rommens J.M., Fraser P.E., St. George-Hyslop P. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. J. Neurochem. 72:1999;999-1008.
28. Liang P., Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science. 257:1992;967-971.
29. Lu Q., Paredes M., Medina M., Zhou J., Cavallo R., Peifer M., Orecchio L., Kosik K.S. Delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol. 144:1999;519-532.
30. Martys-Zage J.L., Kim S.H., Berechid B., Bingham S.J., Chu S., Sklar J., Nye J., Sisodia S.S. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. J. Mol. Neurosci. 15:2000;189-204.
31. Mattson M.P., Zhu H., Yu J., Kindy M.S. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20:2000;1358-1364.
32. Murayama M., Tanaka S., Palacino J., Murayama O., Honda T., Sun X., Yasutake K., Nihonmatsu N., Wolozin B., Takashima A. Direct association of presenilin-1 with beta-catenin. FEBS Lett. 433:1998;73-77.
33. Nakatsuru S., Sudo K., Nakamura Y. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 202:1994;82-87.
34. Patapoutian A., Reichardt L.F. Roles of Wnt proteins in neural development and maintenance. Curr. Opin. Neurobiol. 10:2000;392-399.
35. Postel E.H. NM23-NDP kinase. Int. J. Biochem. Cell. Biol. 30:1998;1291-1295.
36. Ray W.J., Yao M., Mumm J., Schroeter E.H., Saftig P., Wolfe M., Selkoe D.J., Kopan R., Goate A.M. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J. Biol. Chem. 274:1999;36801-36807.
37. Rozmahel R., Huang J., Chen F., Liang Y., Nguyen V., Ikeda M., Levesque G., Yu G., Nishimura M., Mathews P., Schmidt S.D., Mercken M., Bergeron C., Westaway D., St. George-Hyslop P. Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP. Neurobiol. Aging. 23:2002;187-194.
38. Ryan H.E., Lo J., Johnson R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015.
39. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2:1996;864-870.
40. Semenza G.L., Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12:1992;5447-5454.
41. Shen J., Bronson R.T., Chen D.F., Xia W., Selkoe D.J., Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89:1997;629-639.
42. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
43. Shi J., Perry G., Smith M.A., Friedland R.P. Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease. Neurobiol. Aging. 21:2000;357-361.
44. Shimoda L.A., Manalo D.J., Sham J.S., Semenza G.L., Sylvester J.T. Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am. J. Physiol. L. 281:2001;L202-208.
45. Sisodia S.S., St. George-Hyslop P.H. Gamma-secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Natl. Rev. Neurosci. 3:2002;281-290.
46. Song W., Nadeau P., Yuan M., Yang X., Shen J., Yankner B.A. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc. Natl. Acad. Sci. USA. 96:1999;6959-6963.
47. Soriano S., Kang D.E., Fu M., Pestell R., Chevallier N., Zheng H., Koo E.H. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J. Cell Biol. 152:2001;785-794.
48. St. George-Hyslop P.H. Molecular genetics of Alzheimer's disease. Biol. Psychiatry. 47:2000;183-199.
49. Stahl B., Diehlmann A., Sudhof T.C. Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J. Biol. Chem. 274:1999;9141-9148.
50. Steeg P.S., Bevilacqua G., Kopper L., Thorgeirsson U.P., Talmadge J.E., Liotta L.A., Sobel M.E. Evidence for a novel gene associated with low tumor metastatic potential. J. Natl. Cancer Inst. 80:1988;200-204.
51. Swiatek P.J., Lindsell C.E., del Amo F.F., Weinmaster G., Gridley T. Notch1 is essential for postimplantation development in mice. Genes Dev. 8:1994;707-719.
52. Timmons L., Hersperger E., Woodhouse E., Xu J., Liu L.Z., Shearn A. The expression of the Drosophila awd gene during normal development and in neoplastic brain tumors caused by lgl mutations. Dev. Biol. 158:1993;364-379.
53. Vleminckx K., Kemler R. Cadherins and tissue formation: integrating adhesion and signaling. Bioessays. 21:1999;211-220.
54. Wang G.L., Semenza G.L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268:1993;21513-21518.
55. Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398:1999;513-517.
56. Wong P.C., Zheng H., Chen H., Becher M.W., Sirinathsinghji D.J., Trumbauer M.E., Chen H.Y., Price D.L., Van der Ploeg L.H., Sisodia S.S. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature. 387:1997;288-292.
57. Yu A.Y., Shimoda L.A., Iyer N.V., Huso D.L., Sun X., McWilliams R., Beaty T., Sham J.S., Wiener C.M., Sylvester J.T., Semenza G.L. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J. Clin. Invest. 103:1999;691-696.
58. Yu G., Chen F., Levesque G., Nishimura M., Zhang D.M., Levesque L., Rogaeva E., Xu D., Liang Y., Duthie M., St. George-Hyslop P.H., Fraser P.E. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J. Biol. Chem. 273:1998;16470-16475.
59. Zhou J., Liyanage U., Medina M., Ho C., Simmons A.D., Lovett M., Kosik K.S. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. NeuroReport. 8:1997;2085-2090.