메뉴 건너뛰기




Volumn 115, Issue 1, 2010, Pages 58-67

γ-Hydroxybutyrate and the GABAergic footprint: A metabolomic approach to unpicking the actions of GHB

Author keywords

GABA(A)rho; gamma hydroxybutyrate; metabolomics; NMR spectroscopy

Indexed keywords

4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID RECEPTOR; 4 HYDROXYBUTYRIC ACID; BACLOFEN; VIGABATRIN; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; DRUG RECEPTOR; LIGAND; OXYBATE SODIUM; PYRUVIC ACID;

EID: 77956592294     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06901.x     Document Type: Article
Times cited : (36)

References (94)
  • 1
    • 67649604205 scopus 로고    scopus 로고
    • The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: Balancing the risks and benefits. A focus on clinical data
    • Addolorato G., Leggio L., Ferrulli A., Caputo F. Gasbarrini A. (2009) The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data. Expert Opin. Investig. Drugs 18, 675 686.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 675-686
    • Addolorato, G.1    Leggio, L.2    Ferrulli, A.3    Caputo, F.4    Gasbarrini, A.5
  • 2
    • 0141595051 scopus 로고    scopus 로고
    • Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator γ-hydroxybutyrate (GHB)
    • Andriamampandry C., Taleb O., Viry S., Muller C., Humbert J. P., Gobaille S., Aunis D. Maitre M. (2003) Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator γ-hydroxybutyrate (GHB). FASEB J. 17, 1691 1693.
    • (2003) FASEB J. , vol.17 , pp. 1691-1693
    • Andriamampandry, C.1    Taleb, O.2    Viry, S.3    Muller, C.4    Humbert, J.P.5    Gobaille, S.6    Aunis, D.7    Maitre, M.8
  • 3
    • 33847406317 scopus 로고    scopus 로고
    • Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain
    • Andriamampandry C., Taleb O., Kemmel V., Humbert J. P., Aunis D. Maitre M. (2007) Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain. FASEB J. 21, 885 895.
    • (2007) FASEB J. , vol.21 , pp. 885-895
    • Andriamampandry, C.1    Taleb, O.2    Kemmel, V.3    Humbert, J.P.4    Aunis, D.5    Maitre, M.6
  • 5
    • 0029053175 scopus 로고
    • Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid(B) (GABA(B)) receptor-mediated release of gaba and glutamate (glu) in rat thalamic ventrobasal nucleus (vb) - A possible mechanism for the generation of absence-like seizures induced by GHB
    • Banerjee P. K. Snead O. C. (1995) Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acid(B) (GABA(B)) receptor-mediated release of gaba and glutamate (glu) in rat thalamic ventrobasal nucleus (vb) - a possible mechanism for the generation of absence-like seizures induced by GHB. J. Pharmacol. Exp. Ther. 273, 1534 1543.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 1534-1543
    • Banerjee, P.K.1    Snead, O.C.2
  • 6
    • 21344436812 scopus 로고    scopus 로고
    • Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): A study in GHB-S (sensitive) and GHB-R (resistant) rat lines
    • Barbaccia M. L., Carai M. A. M., Colombo G., Lobina C., Purdy R. H. Gessa G. L. (2005) Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines. Neuropharmacology 49, 48 58.
    • (2005) Neuropharmacology , vol.49 , pp. 48-58
    • Barbaccia, M.L.1    Carai, M.A.M.2    Colombo, G.3    Lobina, C.4    Purdy, R.H.5    Gessa, G.L.6
  • 7
    • 34547098612 scopus 로고    scopus 로고
    • Experiences of gamma hydroxybutyrate (GHB) ingestion: A focus group study
    • Barker J. C., Harris S. L. Dyer J. E. (2007) Experiences of gamma hydroxybutyrate (GHB) ingestion: a focus group study. J. Psychoact. Drugs 39, 115 129.
    • (2007) J. Psychoact. Drugs , vol.39 , pp. 115-129
    • Barker, J.C.1    Harris, S.L.2    Dyer, J.E.3
  • 10
    • 0039351371 scopus 로고    scopus 로고
    • Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
    • DOI 10.1042/0264-6021:3410529
    • Broer S., Broer A., Schneider H. P., Stegen C., Halestrap A. P. Deitmer J. W. (1999) Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem. J. 341, 529 535. (Pubitemid 29389181)
    • (1999) Biochemical Journal , vol.341 , Issue.3 , pp. 529-535
    • Broer, S.1    Broer, A.2    Schneider, H.-P.3    Stegen, C.4    Halestrap, A.P.5    Deitmer, J.W.6
  • 11
    • 0036024231 scopus 로고    scopus 로고
    • Pharmacological characterisation of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors
    • Brown N., Kerby J., Bonnert T. P., Whiting P. J. Wafford K. A. (2002) Pharmacological characterisation of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br. J. Pharmacol. 136, 965 974.
    • (2002) Br. J. Pharmacol. , vol.136 , pp. 965-974
    • Brown, N.1    Kerby, J.2    Bonnert, T.P.3    Whiting, P.J.4    Wafford, K.A.5
  • 13
    • 20444492015 scopus 로고    scopus 로고
    • Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice
    • Carai M. A. M., Colombo G. Gessa G. L. (2005) Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice. Ann. Emerg. Med. 45, 614 619.
    • (2005) Ann. Emerg. Med. , vol.45 , pp. 614-619
    • Carai, M.A.M.1    Colombo, G.2    Gessa, G.L.3
  • 14
    • 2142760082 scopus 로고    scopus 로고
    • The discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors
    • Carter L. P., Unzeitig A. W., Wu H., Chen W., Coop A., Koek W. France C. P. (2004) The discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: the role of GABA(B) and GABA(A) receptors. J. Pharmacol. Exp. Ther. 309, 540 547.
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 540-547
    • Carter, L.P.1    Unzeitig, A.W.2    Wu, H.3    Chen, W.4    Coop, A.5    Koek, W.6    France, C.P.7
  • 15
    • 57749112923 scopus 로고    scopus 로고
    • Behavioral analyses of GHB: Receptor mechanisms
    • Carter L. P., Koek W. France C. P. (2009) Behavioral analyses of GHB: receptor mechanisms. Pharmacol. Ther. 121, 100 114.
    • (2009) Pharmacol. Ther. , vol.121 , pp. 100-114
    • Carter, L.P.1    Koek, W.2    France, C.P.3
  • 16
    • 0142179223 scopus 로고    scopus 로고
    • Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid
    • Castelli M. P., Ferraro L., Mocci I., Carta F., Carai M. A. M., Antonelli T., Tanganelli S., Cignarella G. Gessa G. L. (2003) Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid. J. Neurochem. 87, 722 732.
    • (2003) J. Neurochem. , vol.87 , pp. 722-732
    • Castelli, M.P.1    Ferraro, L.2    Mocci, I.3    Carta, F.4    Carai, M.A.M.5    Antonelli, T.6    Tanganelli, S.7    Cignarella, G.8    Gessa, G.L.9
  • 17
    • 6344219742 scopus 로고    scopus 로고
    • A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor
    • Castelli M. P., Pibiri F., Carboni G. Piras A. P. (2004) A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor. CNS Drug Rev. 10, 243 260.
    • (2004) CNS Drug Rev. , vol.10 , pp. 243-260
    • Castelli, M.P.1    Pibiri, F.2    Carboni, G.3    Piras, A.P.4
  • 18
    • 33750089730 scopus 로고    scopus 로고
    • GABA(A) receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol
    • Chandra D., Jia F., Liang J. et al. (2006) GABA(A) receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc. Natl Acad. Sci. USA 103, 15230 15235.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 15230-15235
    • Chandra, D.1    Jia, F.2    Liang, J.3
  • 20
    • 0034692175 scopus 로고    scopus 로고
    • GABA-activated ligand gated ion channels: Medicinal chemistry and molecular biology
    • Chebib M. Johnston G. A. R. (2000) GABA-activated ligand gated ion channels: medicinal chemistry and molecular biology. J. Med. Chem. 43, 1427 1447.
    • (2000) J. Med. Chem. , vol.43 , pp. 1427-1447
    • Chebib, M.1    Johnston, G.A.R.2
  • 23
    • 0036179409 scopus 로고    scopus 로고
    • Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice
    • Cook C. D., Aceto M. D., Coop A. Beardsley P. M. (2002) Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice. Psychopharmacology 160, 99 106.
    • (2002) Psychopharmacology , vol.160 , pp. 99-106
    • Cook, C.D.1    Aceto, M.D.2    Coop, A.3    Beardsley, P.M.4
  • 24
    • 33344457016 scopus 로고    scopus 로고
    • Effects of combining ethanol (EtOH) with gamma-hydroxybutyrate (GHB) on the discriminative stimulus, locomotor, and motor-impairing functions of GHB in mice
    • Cook C. D., Biddlestone L., Coop A. Beardsley P. M. (2006) Effects of combining ethanol (EtOH) with gamma-hydroxybutyrate (GHB) on the discriminative stimulus, locomotor, and motor-impairing functions of GHB in mice. Psychopharmacology 185, 112 122.
    • (2006) Psychopharmacology , vol.185 , pp. 112-122
    • Cook, C.D.1    Biddlestone, L.2    Coop, A.3    Beardsley, P.M.4
  • 25
    • 0020644737 scopus 로고
    • 31P MRS studies on cerebral energy metabolism under conditions of hypoglycaemia and hypoxia in vitro
    • Cox D. W. G., Morris P. G., Feeney F. Bachelard H. S. (1983) 31P MRS studies on cerebral energy metabolism under conditions of hypoglycaemia and hypoxia in vitro. Biochem. J. 212, 365 370.
    • (1983) Biochem. J. , vol.212 , pp. 365-370
    • Cox, D.W.G.1    Morris, P.G.2    Feeney, F.3    Bachelard, H.S.4
  • 27
    • 67649397435 scopus 로고    scopus 로고
    • The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-mediated uptake and inhibition
    • Cui D. P. Morris M. E. (2009) The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition. Drug Metab. Dispos. 37, 1404 1410.
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 1404-1410
    • Cui, D.P.1    Morris, M.E.2
  • 28
    • 0015981343 scopus 로고
    • The action of β-phenyl-GABA derivatives on neurones of the cat cerebral cortex
    • Davies J. Watkins J. C. (1974) The action of β-phenyl-GABA derivatives on neurones of the cat cerebral cortex. Brain Res. 70, 501 505.
    • (1974) Brain Res. , vol.70 , pp. 501-505
    • Davies, J.1    Watkins, J.C.2
  • 30
    • 57649238618 scopus 로고    scopus 로고
    • SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex
    • Drasbek K., Vardya I., Delenclos M., Gibson K. Jensen K. (2008) SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex. J. Inherit. Metab. Dis. 31, 662 668.
    • (2008) J. Inherit. Metab. Dis. , vol.31 , pp. 662-668
    • Drasbek, K.1    Vardya, I.2    Delenclos, M.3    Gibson, K.4    Jensen, K.5
  • 31
    • 0032540969 scopus 로고    scopus 로고
    • Resolution and conformational analysis of diastereomeric esters of cis and trans-2-(aminomethol)-1-carboxycyclopropanes
    • Duke R. K., Allan R. D., Chebib M., Greenwood J. R. Johnston G. A. R. (1998) Resolution and conformational analysis of diastereomeric esters of cis and trans-2-(aminomethol)-1-carboxycyclopropanes. Tetrahedron Asymmetry 9, 2533 2548.
    • (1998) Tetrahedron Asymmetry , vol.9 , pp. 2533-2548
    • Duke, R.K.1    Allan, R.D.2    Chebib, M.3    Greenwood, J.R.4    Johnston, G.A.R.5
  • 33
    • 77952386385 scopus 로고    scopus 로고
    • Concentration-effect relationship for the drug of abuse γ-hydroxybutyric acid
    • Felmlee M. A., Roiko S. A., Morse B. L. Morris M. E. (2010) Concentration-effect relationship for the drug of abuse γ-hydroxybutyric acid. J. Pharmacol. Exp. Ther. 333, 764 771.
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 764-771
    • Felmlee, M.A.1    Roiko, S.A.2    Morse, B.L.3    Morris, M.E.4
  • 34
    • 0029098821 scopus 로고
    • Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists
    • Froestl W., Mickel S. J., Hall R. G. et al. (1995a) Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J. Med. Chem. 38, 3297 3312.
    • (1995) J. Med. Chem. , vol.38 , pp. 3297-3312
    • Froestl, W.1    Mickel, S.J.2    Hall, R.G.3
  • 35
    • 0029165253 scopus 로고
    • Phosphinic acid analogs of GABA. 2. Selective, orally active GABA(B) antagonists
    • Froestl W., Mickel S. J., Vonsprecher G. et al. (1995b) Phosphinic acid analogs of GABA. 2. Selective, orally active GABA(B) antagonists. J. Med. Chem. 38, 3313 3331.
    • (1995) J. Med. Chem. , vol.38 , pp. 3313-3331
    • Froestl, W.1    Mickel, S.J.2    Vonsprecher, G.3
  • 36
    • 36549058202 scopus 로고    scopus 로고
    • Activation of GABAA Receptors: Views from Outside the Synaptic Cleft
    • Glykys J. Mody I. (2007) Activation of GABAA Receptors: views from Outside the Synaptic Cleft. Neuron 56, 763 770.
    • (2007) Neuron , vol.56 , pp. 763-770
    • Glykys, J.1    Mody, I.2
  • 37
    • 0033005441 scopus 로고    scopus 로고
    • Gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo
    • Gobaille S., Hechler V., Andriamampandry C., Kemmel V. Maitre M. (1999) gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo. J. Pharmacol. Exp. Ther. 290, 303 309.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 303-309
    • Gobaille, S.1    Hechler, V.2    Andriamampandry, C.3    Kemmel, V.4    Maitre, M.5
  • 38
    • 0028842165 scopus 로고
    • Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat
    • Godbout R., Jelenic P., Labrie C., Schmitt M. Bourguignon J. J. (1995) Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat. Brain Res. 673, 157 160.
    • (1995) Brain Res. , vol.673 , pp. 157-160
    • Godbout, R.1    Jelenic, P.2    Labrie, C.3    Schmitt, M.4    Bourguignon, J.J.5
  • 40
    • 33846890036 scopus 로고    scopus 로고
    • D.Phil., Dept of Biochemistry, The University of Oxford, Oxford.
    • 13C NMR. D.Phil., Dept of Biochemistry, The University of Oxford, Oxford.
    • (1997) 13C NMR
    • Griffin, J.L.1
  • 42
    • 0025166358 scopus 로고
    • Trans-gamma-hydroxycrotonic acid binding sites in brain - Evidence for a subpopulation of gamma hydroxybutyrate sites
    • Hechler V., Schmitt M., Bourguignon J. J. Maitre M. (1990) Trans-gamma-hydroxycrotonic acid binding sites in brain - evidence for a subpopulation of gamma hydroxybutyrate sites. Neurosci. Lett. 110, 204 209.
    • (1990) Neurosci. Lett. , vol.110 , pp. 204-209
    • Hechler, V.1    Schmitt, M.2    Bourguignon, J.J.3    Maitre, M.4
  • 43
    • 72749102220 scopus 로고    scopus 로고
    • Altered GABA(A,slow) Inhibition and Network Oscillations in Mice Lacking the GABA(A) Receptor beta(3) Subunit
    • Hentschke H., Benkwitz C., Banks M. I., Perkins M. G., Homanics G. E. Pearce R. A. (2009) Altered GABA(A,slow) Inhibition and Network Oscillations in Mice Lacking the GABA(A) Receptor beta(3) Subunit. J. Neurophysiol. 102, 3643 3655.
    • (2009) J. Neurophysiol. , vol.102 , pp. 3643-3655
    • Hentschke, H.1    Benkwitz, C.2    Banks, M.I.3    Perkins, M.G.4    Homanics, G.E.5    Pearce, R.A.6
  • 44
    • 0029023018 scopus 로고
    • Characterization of the antiabsence effects of SCH-50911, a GABA(B) receptor antagonist in the lethargic mouse, gamma-hydroxybutyrate and pentyleneetetrazole models
    • Hosford D. A., Wang Y., Liu C. C. Snead O. C. (1995) Characterization of the antiabsence effects of SCH-50911, a GABA(B) receptor antagonist in the lethargic mouse, gamma-hydroxybutyrate and pentyleneetetrazole models. J. Pharmacol. Exp. Ther. 274, 1399 1403.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 1399-1403
    • Hosford, D.A.1    Wang, Y.2    Liu, C.C.3    Snead, O.C.4
  • 45
    • 0031060619 scopus 로고    scopus 로고
    • Effect of gamma-hydroxybutyrate on central dopamine release in vivo
    • Howard S. G. Feigenbaum J. J. (1997) Effect of gamma-hydroxybutyrate on central dopamine release in vivo. Biochem. Pharmacol. 53, 103 110.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 103-110
    • Howard, S.G.1    Feigenbaum, J.J.2
  • 46
    • 0034744229 scopus 로고    scopus 로고
    • B receptors in mouse neocortical neurons
    • B receptors in mouse neocortical neurons. Cereb. Cortex 11, 424 429.
    • (2001) Cereb. Cortex , vol.11 , pp. 424-429
    • Jensen, K.1    Mody, I.2
  • 47
    • 0025193071 scopus 로고
    • Novel GABAA receptor alpha subunit is expressed only in cerebellar granule cells
    • Kato K. (1990) Novel GABAA receptor alpha subunit is expressed only in cerebellar granule cells. J. Mol. Biol. 214, 619 624.
    • (1990) J. Mol. Biol. , vol.214 , pp. 619-624
    • Kato, K.1
  • 48
    • 10744226168 scopus 로고    scopus 로고
    • Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B(1))-deficient mice
    • Kaupmann K., Cryan J. F., Wellendorph P. et al. (2003) Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B(1))-deficient mice. Eur. J. Neurosci. 18, 2722 2730.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 2722-2730
    • Kaupmann, K.1    Cryan, J.F.2    Wellendorph, P.3
  • 49
    • 23944493552 scopus 로고    scopus 로고
    • Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABA(A) conductances in rat neocortex
    • Keros S. Hablitz J. J. (2005) Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABA(A) conductances in rat neocortex. J. Neurophysiol. 94, 2073 2085.
    • (2005) J. Neurophysiol. , vol.94 , pp. 2073-2085
    • Keros, S.1    Hablitz, J.J.2
  • 50
    • 51049120436 scopus 로고    scopus 로고
    • Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients
    • Knerr I., Gibson K. M., Jakobs C. Pearl P. L. (2008) Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients. CNS Spectr. 13, 598 605.
    • (2008) CNS Spectr. , vol.13 , pp. 598-605
    • Knerr, I.1    Gibson, K.M.2    Jakobs, C.3    Pearl, P.L.4
  • 51
    • 33645702650 scopus 로고    scopus 로고
    • Discriminative stimulus effects of flumazenil: Perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone
    • Koek W., Carter L. P., Wu H. F., Coop A. France C. P. (2006) Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone. Behav. Pharmacol. 17, 239 247.
    • (2006) Behav. Pharmacol. , vol.17 , pp. 239-247
    • Koek, W.1    Carter, L.P.2    Wu, H.F.3    Coop, A.4    France, C.P.5
  • 52
    • 0018250088 scopus 로고
    • Inhibitors of GABA uptake - Synthesis and H-1 NMR spectroscopic investigations of guvacine (3RS,4SR)-4-hydroxypiperidine-3-carboxylic acid, and related compounds
    • Krogsgaardlarsen P., Thyssen K. Schaumburg K. (1978) Inhibitors of GABA uptake - synthesis and H-1 NMR spectroscopic investigations of guvacine (3RS,4SR)-4-hydroxypiperidine-3-carboxylic acid, and related compounds. Acta Chem. Scand. B-Org. Chem. Biochem. 32, 327 334.
    • (1978) Acta Chem. Scand. B-Org. Chem. Biochem. , vol.32 , pp. 327-334
    • Krogsgaardlarsen, P.1    Thyssen, K.2    Schaumburg, K.3
  • 53
    • 58149365834 scopus 로고
    • Adiabatic pulses for wideband inversion and broadband decoupling
    • Kupce E. Freeman R. (1995) Adiabatic pulses for wideband inversion and broadband decoupling. J. Magn. Reson. A 115, 273 276.
    • (1995) J. Magn. Reson. A , vol.115 , pp. 273-276
    • Kupce, E.1    Freeman, R.2
  • 54
    • 0036182507 scopus 로고    scopus 로고
    • A comparison of cell and tissue extraction techniques using high-resolution 1H NMR spectroscopy
    • Le Belle J. E., Harris N. G., Williams S. R. Bhakoo K. K. (2002) A comparison of cell and tissue extraction techniques using high-resolution 1H NMR spectroscopy. NMR Biomed. 15, 37 44.
    • (2002) NMR Biomed. , vol.15 , pp. 37-44
    • Le Belle, J.E.1    Harris, N.G.2    Williams, S.R.3    Bhakoo, K.K.4
  • 55
    • 36649008097 scopus 로고    scopus 로고
    • Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex
    • Li Q., Kuhn C. M., Wilson W. A. Lewis D. V. (2007) Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex. Neuroscience 150, 82 92.
    • (2007) Neuroscience , vol.150 , pp. 82-92
    • Li, Q.1    Kuhn, C.M.2    Wilson, W.A.3    Lewis, D.V.4
  • 57
    • 0032219608 scopus 로고    scopus 로고
    • Gamma-hydroxybutyrate is a GABA(B) receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons
    • Madden T. E. Johnson S. W. (1998) Gamma-hydroxybutyrate is a GABA(B) receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons. J. Pharmacol. Exp. Ther. 287, 261 265.
    • (1998) J. Pharmacol. Exp. Ther. , vol.287 , pp. 261-265
    • Madden, T.E.1    Johnson, S.W.2
  • 58
    • 0030895783 scopus 로고    scopus 로고
    • The γ-hydroxybutyrate signalling system in brain. Organization and functional implications
    • Maitre M. (1997) The γ-hydroxybutyrate signalling system in brain. Organization and functional implications. Prog. Neurobiol. 51, 337 361.
    • (1997) Prog. Neurobiol. , vol.51 , pp. 337-361
    • Maitre, M.1
  • 60
    • 70249095889 scopus 로고    scopus 로고
    • Narcolepsy and depression and the neurobiology of gammahydroxybutyrate
    • Mamelak M. (2009) Narcolepsy and depression and the neurobiology of gammahydroxybutyrate. Prog. Neurobiol. 89, 193 219.
    • (2009) Prog. Neurobiol. , vol.89 , pp. 193-219
    • Mamelak, M.1
  • 61
    • 0031577966 scopus 로고    scopus 로고
    • Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABA(B) receptor agonist
    • Mathivet P., Bernasconi R., DeBarry J., Marescaux C. Bittiger H. (1997) Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABA(B) receptor agonist. Eur. J. Pharmacol. 321, 67 75.
    • (1997) Eur. J. Pharmacol. , vol.321 , pp. 67-75
    • Mathivet, P.1    Bernasconi, R.2    Debarry, J.3    Marescaux, C.4    Bittiger, H.5
  • 63
    • 67649341982 scopus 로고    scopus 로고
    • Gamma-hydroxybutyrate (GHB) induces GABA(B) receptor independent intracellular Ca2 + transients in astrocytes, but has no effect on GHB or GABA(B) receptors of medium spiny neurons in the nucleus accumbens
    • Molnar T., Antal K., Nyitrai G. Emri Z. (2009) Gamma-hydroxybutyrate (GHB) induces GABA(B) receptor independent intracellular Ca2 + transients in astrocytes, but has no effect on GHB or GABA(B) receptors of medium spiny neurons in the nucleus accumbens. Neuroscience 162, 268 281.
    • (2009) Neuroscience , vol.162 , pp. 268-281
    • Molnar, T.1    Antal, K.2    Nyitrai, G.3    Emri, Z.4
  • 64
    • 53749107434 scopus 로고    scopus 로고
    • Overview of the proton-coupled MCT (SLC16A) family of transporters: Characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid
    • Morris M. E. Felmlee M. A. (2008) Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. Aaps J. 10, 311 321.
    • (2008) Aaps J. , vol.10 , pp. 311-321
    • Morris, M.E.1    Felmlee, M.A.2
  • 66
    • 34547092147 scopus 로고    scopus 로고
    • Understanding your inhibitions. Modulation of brain cortical metabolism by GABA-B receptors
    • Nasrallah F., Griffin J. L., Balcar V. J. Rae C. (2007) Understanding your inhibitions. Modulation of brain cortical metabolism by GABA-B receptors. J. Cereb. Blood Flow Metab. 27, 1510 1520.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 1510-1520
    • Nasrallah, F.1    Griffin, J.L.2    Balcar, V.J.3    Rae, C.4
  • 67
    • 57249086444 scopus 로고    scopus 로고
    • Understanding your inhibitions. Effects of GABA and GABAA receptors on brain cortical metabolism
    • Nasrallah F., Griffin J. L., Balcar V. J. Rae C. (2009) Understanding your inhibitions. Effects of GABA and GABAA receptors on brain cortical metabolism. J. Neurochem. 108, 57 71.
    • (2009) J. Neurochem. , vol.108 , pp. 57-71
    • Nasrallah, F.1    Griffin, J.L.2    Balcar, V.J.3    Rae, C.4
  • 68
    • 77949284744 scopus 로고    scopus 로고
    • A metabonomic study of inhibition of GABA uptake in the cerebral cortex
    • Nasrallah F. A., Balcar V. J. Rae C. (2010) A metabonomic study of inhibition of GABA uptake in the cerebral cortex. Metabolomics 6, 67 77.
    • (2010) Metabolomics , vol.6 , pp. 67-77
    • Nasrallah, F.A.1    Balcar, V.J.2    Rae, C.3
  • 69
    • 67349124390 scopus 로고    scopus 로고
    • Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: Assessment using biotelemetry
    • van Nieuwenhuijzen P. S. McGregor I. S. (2009) Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry. Drug Alcohol Depend. 103, 137 147.
    • (2009) Drug Alcohol Depend. , vol.103 , pp. 137-147
    • Van Nieuwenhuijzen, P.S.1    McGregor, I.S.2
  • 70
    • 70350686715 scopus 로고    scopus 로고
    • Regulation of cortical microcircuits by unitary GABA-mediated volume transmission
    • Olah S., Fule M., Komlosi G., Varga C., Baldi R., Barzo P. Tamas G. (2009) Regulation of cortical microcircuits by unitary GABA-mediated volume transmission. Nature 461, 1278 U1113.
    • (2009) Nature , vol.461
    • Olah, S.1    Fule, M.2    Komlosi, G.3    Varga, C.4    Baldi, R.5    Barzo, P.6    Tamas, G.7
  • 72
    • 0038221058 scopus 로고    scopus 로고
    • Clinical spectrum of succinic semialdehyde dehydrogenase deficiency
    • Pearl P. L., Gibson K. M., Acosta M. T. et al. (2003) Clinical spectrum of succinic semialdehyde dehydrogenase deficiency. Neurology 60, 1413 1417.
    • (2003) Neurology , vol.60 , pp. 1413-1417
    • Pearl, P.L.1    Gibson, K.M.2    Acosta, M.T.3
  • 73
    • 77952877456 scopus 로고    scopus 로고
    • Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats
    • Pedraza C., Garcia F. B. Navarro J. F. (2009) Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats. Int. J. Neuropsychopharmacol. 12, 1165 1177.
    • (2009) Int. J. Neuropsychopharmacol. , vol.12 , pp. 1165-1177
    • Pedraza, C.1    Garcia, F.B.2    Navarro, J.F.3
  • 74
    • 0034319176 scopus 로고    scopus 로고
    • Strategies for studies of potentially neurotoxic mechanisms involving deficient transport of L-glutamate: Antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pigs brain slices
    • Rae C., Lawrance M. L., Dias L. S., Provis T., Bubb W. A. Balcar V. J. (2000) Strategies for studies of potentially neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pigs brain slices. Brain Res. Bull. 53, 373 381.
    • (2000) Brain Res. Bull. , vol.53 , pp. 373-381
    • Rae, C.1    Lawrance, M.L.2    Dias, L.S.3    Provis, T.4    Bubb, W.A.5    Balcar, V.J.6
  • 76
    • 33746525514 scopus 로고    scopus 로고
    • A metabolomic approach to ionotropic glutamate receptor subtype function: A nuclear magnetic resonance in vitro investigation
    • Rae C., Moussa C. E.-H., Griffin J. L., Parekh S. B., Bubb W. A., Hunt N. H. Balcar V. J. (2006) A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation. J. Cereb. Blood Flow Metab. 26, 1005 1017.
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1005-1017
    • Rae, C.1    Moussa, C.E.-H.2    Griffin, J.L.3    Parekh, S.B.4    Bubb, W.A.5    Hunt, N.H.6    Balcar, V.J.7
  • 77
    • 64349088964 scopus 로고    scopus 로고
    • Now i know my ABC. A systems neurochemistry and functional metabolomic approach to understanding the GABAergic system
    • Rae C., Nasrallah F. A., Griffin J. L. Balcar V. J. (2009) Now I know my ABC. A systems neurochemistry and functional metabolomic approach to understanding the GABAergic system. J. Neurochem. 109 (Suppl. 1 109 116.
    • (2009) J. Neurochem. , vol.109 , Issue.SUPPL. 1 , pp. 109-116
    • Rae, C.1    Nasrallah, F.A.2    Griffin, J.L.3    Balcar, V.J.4
  • 79
    • 0032545654 scopus 로고    scopus 로고
    • The anxiolytic effect of gamma-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil
    • Schmidt-Mutter C., Pain L., Sandner G., Gobaille S. Maitre M. (1998) The anxiolytic effect of gamma-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil. Eur. J. Pharmacol. 342, 21 27.
    • (1998) Eur. J. Pharmacol. , vol.342 , pp. 21-27
    • Schmidt-Mutter, C.1    Pain, L.2    Sandner, G.3    Gobaille, S.4    Maitre, M.5
  • 80
    • 4644248656 scopus 로고    scopus 로고
    • Gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABA(B) receptors
    • Schweitzer P., Roberto M., Madamba S. G. Siggins G. R. (2004) gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABA(B) receptors. J. Pharmacol. Exp. Ther. 311, 172 179.
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 172-179
    • Schweitzer, P.1    Roberto, M.2    Madamba, S.G.3    Siggins, G.R.4
  • 81
    • 0000842606 scopus 로고    scopus 로고
    • A phase-cycling algorithm for reducing sidebands in adiabatic decoupling
    • Skinner T. E. Bendall M. R. (1997) A phase-cycling algorithm for reducing sidebands in adiabatic decoupling. J. Magn. Reson. 124, 474 478.
    • (1997) J. Magn. Reson. , vol.124 , pp. 474-478
    • Skinner, T.E.1    Bendall, M.R.2
  • 82
    • 0026539825 scopus 로고
    • NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: Pharmacological characterization
    • Suzdak P. D., Frederiksen K., Andersen K. E., Sorensen P. O., Knutsen L. J. Nielsen E. B. (1992) NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur. J. Pharmacol. 224, 189 198.
    • (1992) Eur. J. Pharmacol. , vol.224 , pp. 189-198
    • Suzdak, P.D.1    Frederiksen, K.2    Andersen, K.E.3    Sorensen, P.O.4    Knutsen, L.J.5    Nielsen, E.B.6
  • 83
    • 0035059628 scopus 로고    scopus 로고
    • Interpreting PET and fMRI measures of functional neural activity: The effects of synaptic inhibition on cortical activation in human imaging studies
    • Tagamets M. A. Horwitz B. (2001) Interpreting PET and fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies. Brain Res. Bull. 54, 267 273.
    • (2001) Brain Res. Bull. , vol.54 , pp. 267-273
    • Tagamets, M.A.1    Horwitz, B.2
  • 84
    • 0141518668 scopus 로고    scopus 로고
    • A man with sudden alteration of mental status - Ingestion of 1,4-butanediol, resulting in gamma-hydroxybutyrate intoxication
    • Tancredi D. N., Shannon M. W., Goldstein J. N., Kosowsky J., Lai M. Singh M. K. (2003) A man with sudden alteration of mental status - Ingestion of 1,4-butanediol, resulting in gamma-hydroxybutyrate intoxication. New Engl. J. Med. 349, 1267 1275.
    • (2003) New Engl. J. Med. , vol.349 , pp. 1267-1275
    • Tancredi, D.N.1    Shannon, M.W.2    Goldstein, J.N.3    Kosowsky, J.4    Lai, M.5    Singh, M.K.6
  • 85
    • 33750078683 scopus 로고    scopus 로고
    • Effectiveness of extracellular lactate/pyruvate for sustaining synaptic vesicle proton gradient generation and vesicular accumulation of GABA
    • Tarasenko A. S., Linetska M. V., Storchak L. G. Himmelreich N. H. (2006) Effectiveness of extracellular lactate/pyruvate for sustaining synaptic vesicle proton gradient generation and vesicular accumulation of GABA. J. Neurochem. 99, 787 796.
    • (2006) J. Neurochem. , vol.99 , pp. 787-796
    • Tarasenko, A.S.1    Linetska, M.V.2    Storchak, L.G.3    Himmelreich, N.H.4
  • 86
    • 53549118028 scopus 로고    scopus 로고
    • Characterization and pharmacology of the ghb receptor
    • in. Kuhar, M. J. ed.), Vol. 1139, pp. Blackwell Publishing. Oxford.
    • Ticku M. K. Mehta A. K. (2008) Characterization and pharmacology of the ghb receptor, in Drug Addiction: Research Frontiers and Treatment Advances (Kuhar M. J., ed.), Vol. 1139, pp. 374 385. Blackwell Publishing, Oxford.
    • (2008) Drug Addiction: Research Frontiers and Treatment Advances , pp. 374-385
    • Ticku, M.K.1    Mehta, A.K.2
  • 88
    • 0035807757 scopus 로고    scopus 로고
    • Cis-4-amino-crotonic acid activates [alpha]6 subunit-containing GABAA but not GABAC receptors in granule cells of adult rat cerebellar slices
    • Wall M. J. (2001) Cis-4-amino-crotonic acid activates [alpha]6 subunit-containing GABAA but not GABAC receptors in granule cells of adult rat cerebellar slices. Neurosci. Lett. 316, 37 40.
    • (2001) Neurosci. Lett. , vol.316 , pp. 37-40
    • Wall, M.J.1
  • 89
    • 0026612363 scopus 로고
    • The distribution of 13 GABA-A receptor subunit messenger-RNAs in the rat brain. 1. Telencephalon, Diencephalon, Mesencephalon
    • Wisden W., Laurie D. J., Monyer H. Seeburg P. H. (1992) The distribution of 13 GABA-A receptor subunit messenger-RNAs in the rat brain. 1. Telencephalon, Diencephalon, Mesencephalon. J. Neurosci. 12, 1040 1062.
    • (1992) J. Neurosci. , vol.12 , pp. 1040-1062
    • Wisden, W.1    Laurie, D.J.2    Monyer, H.3    Seeburg, P.H.4
  • 91
    • 0026585373 scopus 로고
    • High-affinity ligands for diazepam-insensitive benzodiazepine receptors
    • Wong G. Skolnick P. (1992) High-affinity ligands for diazepam-insensitive benzodiazepine receptors. Eur. J. Pharmacol.-Mol. Pharmacol. Sect. 225, 63 68.
    • (1992) Eur. J. Pharmacol.-Mol. Pharmacol. Sect. , vol.225 , pp. 63-68
    • Wong, G.1    Skolnick, P.2
  • 92
    • 0343781912 scopus 로고
    • Glutamic acid, other amino acids and related compounds as substrate for cerebral tissues - Their effects on tissue phosphates
    • Woodman R. J. McIlwain H. (1961) Glutamic acid, other amino acids and related compounds as substrate for cerebral tissues - their effects on tissue phosphates. Biochem. J. 81, 83.
    • (1961) Biochem. J. , vol.81 , pp. 83
    • Woodman, R.J.1    McIlwain, H.2
  • 93
    • 19544375437 scopus 로고    scopus 로고
    • Agitation is common in gamma-hydroxybutyrate toxicity
    • Zvosec D. L. Smith S. W. (2005) Agitation is common in gamma-hydroxybutyrate toxicity. Am. J. Emerg. Med. 23, 316 320.
    • (2005) Am. J. Emerg. Med. , vol.23 , pp. 316-320
    • Zvosec, D.L.1    Smith, S.W.2
  • 94
    • 0034744108 scopus 로고    scopus 로고
    • 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes
    • 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes. Glia 34, 200 212.
    • (2001) Glia , vol.34 , pp. 200-212
    • Zwingmann, C.1    Richter-Landsberg, C.2    Leibfritz, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.