Understanding your inhibitions: Modulation of brain cortical metabolism by GABAB receptors

Journal of Cerebral Blood Flow and Metabolism

Volumn 27, Issue 8, 2007, Pages 1510-1520

  Nasrallah, Fatima A ^a   Griffin, Julian L ^b   Balcar, Vladimir J ^c   Rae, Caroline ^a,d  

^a NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Aminobutyric acid; 13C NMR spectroscopy; Functional brain imaging; Inhibitory activity; Metabolomics; Principal components analysis

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; [3 (3,4 DICHLOROBENZYLAMINO)PROPYL](DIETHOXYMETHYL)PHOSPHINIC ACID; BACLOFEN; CARBON 13; PHACLOFEN; PROTON; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; BRAIN TISSUE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG POTENCY; GUINEA PIG; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; BACLOFEN; BENZYLAMINES; CARBON ISOTOPES; CEREBRAL CORTEX; GABA AGONISTS; GABA ANTAGONISTS; GUINEA PIGS; MOLECULAR STRUCTURE; MORPHOLINES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHINIC ACIDS; PRINCIPAL COMPONENT ANALYSIS; RECEPTORS, GABA-B;

EID: 34547092147     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600453     Document Type: Article

References (49)

1. Ackermann RF, Finch DM, Babb TL, Engel J (1984) Increased glucose-metabolism during long-duration recurrent inhibition of hippocampal pyramidal cells. J Neurosci 4:251-64
2. 13C NMR spectroscopy. Biochem J 266:133-9
3. A receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev 50:291-313
4. B receptors. Physiol Rev 84:835-67
5. Billinton A, Upton N, Bowery NG (1999) GABA(B) receptor isoforms GBR1a and GBR1b appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum. Br J Pharmacol 126:1387-92
6. B receptors: structure and function. Pharmacol Rev 54:247-64
7. Chang L, Cloak CC, Ernst T (2003) Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders. J Clin Psychiatry 64(Suppl 3):7-14
8. B-like receptor protein in the rat central nervous system. Brain Res 989:135-46
9. Chatton JY, Pellerin L, Magistretti PJ (2003) GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission. Proc Natl Acad SciUSA 100:12456-61
10. Davies J, Watkins JC (1974) The action of β-phenyl-GABA derivatives on neurones of the cat cerebral cortex. Brain Res 70:501-5
11. Deisz RA, Billard J-M, Zieglgansberger W (1997) Presynaptic and postsynaptic GABAB receptors of neocortical neurons of the rat in vitro: differences in pharmacology and ionic mechanisms. Synapse 25:62-72
12. Floyer-Lea A, Wylezinska M, Kincses T, Matthews PM (2005) Rapid modulation of GABA concentration in human sensorimotor cortex during motor learning. J Neurophysiol 95:1639-44
13. Fritschy JM, Meskenaite V, Weinmann O, Honer M, Benke D, Möhler H (1999) GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. Eur J Neurosci 11:761-8
14. B agonists. J Med Chem 38:3297-312
15. Goodacre R, Vaidyanathan S, Dunn WB, GHarrigan GG, Kell DB (2004) Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol 22:245-52
16. Kerr DIB, Ong J, Prager RH, Gynther BD, Curtis DR (1987) Phaclofen - a peripheral ad central baclofen antagonist. Brain Res 405:150-4
17. Kupce E, Freeman R (1995) Adiabatic pulses for wideband inversion and broadband decoupling. J Magn Reson A 115:273-6
18. B autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol 237:191-5
19. Lauritzen M (2005) Reading vascular changes in brain imaging: is dendritic calcium the key? Nat Rev Neurosci 6:77-85
20. Le Belle JE, Harris NG, Williams SR, Bhakoo KK (2002) A comparison of cell and tissue extraction techniques using high-resolution 1H NMR spectroscopy. NMR Biomed 15:37-44
21. Lozovaya N, Melnik S, Tsintsadze T, Grebenyuk S, Kirichok Y, Krishtal O (2004) Protective cap overCA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density. Brain Res 1011:195-205
22. Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, Schwartz WJ, Sokoloff L (1980) Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem 34:213-5
23. McIlwain H, Bachelard H (1985) Biochemistry and the central nervous system. Edinburgh: Churchill Livingstone
24. Moussa CE-H, Mitrovic AD, Vandenberg RJ, Provis T, Rae C, Bubb WA, Balcar VJ (2002) Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1′S, 2′R)-2-(carboxycyclopropyl) glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochem Res 27:27-35
25. Moussa CE-H, Rae C, Bubb WA, Griffin JL, Deters NA, Balcar VJ (2007) Inhibitors of glutamate transport modulate distinct patterns in brain metabolism. J Neurosci Res 85:342-50
26. Olpe H-R, Karlsson G, Pozza MF, Brugger F, Steinmann M, Van Riezen H, Fagg G, Hall RG, Froestl W, Bittinger H (1990) CGP 35348 - a centrally active blocker of GABA-B receptors. Eur J Pharmacol 187:27-38
27. B receptor antagonist in rat neocortical slices. Eur J Pharmacol 362:35-41
28. Palacios JM, Kuhar MJ, Rapoport SI, London ED (1982) Effects of γ-aminobutyric acid agonist and antagonist drugs on local cerebral glucose utilization. J Neurosci 2:853-60
29. 2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron 50:603-16
30. A receptors activation. Epilepsy Res 19:45-54
31. Pham TM, Nurse S, Lacaille JC (1998) Distinct GABA(B) actions via synaptic and extrasynaptic receptors in rat hippocampus in vitro. J Neurophysiol 80:297-308
32. B receptors at inhibitory synapses in the CA1 region of the rat hippocampus. Br J Pharmacol 127:211-9
33. Rae C, Hansen JT, Bubb WA, Bröer S, Bröer A (2005a) Alanine transport, metabolism and cycling in the brain. Proc Int Soc Magn Reson Med 2481
34. Rae C, Hare N, Bubb WA, McEwan SR, Bröer A, McQuillan JA, Balcar VJ, Conigrave AD, Bröer S (2003) Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. J Neurochem 85:503-14
35. Rae C, Lawrance ML, Dias LS, Provis T, Bubb WA, Balcar VJ (2000) Strategies for studies of potentially neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pigs brain slices. Brain Res Bull 53:373-81
36. 13C NMR spectroscopy and metabolomic study. J Neurochem 92:405-16
37. Rae C, Moussa CE-H, Griffin JL, Parekh SB, Bubb WA, Hunt NH, Balcar VJ (2006) A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigation. J Cereb Blood Flow Metab 26:1005-17
38. Rochfort S (2005) Metabolomics reviewed: a new 'Omics' platform technology for systems biology and implications for natural products research. J Nat Products 68:1813-20
39. Roland PE, Friberg L (1988) The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance. J Cereb Blood Flow Metab 8:314-23
40. Rudolph U, Crestani F, Möhler H (2001) GABAa receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol Sci 22:188-94
41. Shmuel A, Augath M, Oeltermann A, Logothetis NK (2006) functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nat Neurosci 9:569-77
42. Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci USA 95:316-321
43. Skinner TE, Bendall MR (1997) A phase-cycling algorithm for reducing side bands in adiabatic decoupling. J Magn Resonance 124:474-8
44. Stanton D, Liao LP, Moussa CE-H, Rae C, Bubb WA, Balcar VJ (2003) Can inhibition of glutamate transport contribute to the action of neuroleptics? Psychiatrie (Prague) 7:6-11
45. Tagamets MA, Horwitz B (2001) Interpreting PETand fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies. Brain Res Bull 54:267-73
46. Vigot R, Barbieri SB-OH, Turecek R, Shegimoto R, Zhang Y-P, Lujan R, Jacobson LH, Biermann C-M, Fritschy JM, Vacher C-M, Muller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG, Bettler B (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50:589-601
47. Waagepetersen HS, Sonnewald U, Larsson OM, Schousboe A (2000) A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons. J Neurochem 75:471-9
48. 13C]alanine in astrocytes, neurons and cocultures: implications for glia-neuron interactions in neurotransmitter metabolism. Glia 32:286-303
49. 13C isotopomer analysis of glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes. Glia 34:200-12