Selective γ-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of γ-hydroxybutyric acid

Journal of Neurochemistry

Volumn 87, Issue 3, 2003, Pages 722-732

  Castelli, M Paola ^a   Ferraro, Luca ^b   Mocci, Ignazia ^a   Carta, Francesca ^d   Carai, Mauro A M ^d   Antonelli, Tiziana ^b   Tanganelli, Sergio ^b   Cignarella, Giorgio ^c   Gessa, Gian Luigi ^d  

^a Neuroscienze PharmaNess Scarl   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

GABAB; GHB analogues; Glutamate; GTP S binding; Hippocampus; NCS 382.

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 HYDROXYBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID RECEPTOR; 4 HYDROXYCROTONIC ACID; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; 6,7,8,9 TETRAHYDRO 5 BENZOCYCLOPENTEN 5 OL 4 YLIDENEACETIC ACID; ANESTHETIC AGENT; BACLOFEN; CROTONIC ACID DERIVATIVE; GAMMA (4 METHOXYBENZYL) GAMMA HYDROXYBUTYRIC ACID; GLUTAMATE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; NCS 382; NCS 435; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG EFFECT; HIPPOCAMPUS; HYPNOSIS; LIGAND BINDING; MALE; NERVE FUNCTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SEDATION;

ANIMALS; AUTORADIOGRAPHY; BENZOCYCLOHEPTENES; BINDING, COMPETITIVE; BRAIN CHEMISTRY; EXTRACELLULAR SPACE; GABA ANTAGONISTS; GLUTAMIC ACID; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HIPPOCAMPUS; HYDROXYBUTYRATES; HYPNOTICS AND SEDATIVES; LIGANDS; MALE; MICE; MICE, INBRED DBA; MICRODIALYSIS; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; REFLEX;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0142179223     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02037.x     Document Type: Article

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