Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats

International Journal of Neuropsychopharmacology

Volumn 12, Issue 9, 2009, Pages 1165-1177

  Pedraza, Carmen ^a   García, Francisca Belén ^a   Navarro, José Francisco ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Gammahydroxybutyric acid; neurological damage; neurotoxicity; spatial memory; working memory

Indexed keywords

4 HYDROXYBUTYRIC ACID; NCS 382; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; 4 HYDROXYBUTYRIC ACID RECEPTOR; 4-HYDROXYBUTYRIC ACID RECEPTOR; CELL SURFACE RECEPTOR; FUSED ALICYCLIC AROMATIC COMPOUND; OXYBATE SODIUM; STREET DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; GRIP STRENGTH; HIPPOCAMPAL CA1 REGION; MALE; MAZE TEST; MEMORY DISORDER; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; STEREOMETRY; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MEMORY; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT; REFLEX; TIME; TOXICITY AND INTOXICATION; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; BENZOCYCLOHEPTENES; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MALE; MEMORY; NERVE DEGENERATION; NEUROTOXICITY SYNDROMES; PREFRONTAL CORTEX; RATS; RATS, WISTAR; RECEPTORS, CELL SURFACE; REFLEX; SODIUM OXYBATE; STREET DRUGS; TIME FACTORS;

EID: 77952877456     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145709000157     Document Type: Article

References (63)

1. Amaral DG, Witter MP (1994). Hippocampal formation. In: Paxinos G (Ed.), The Rat Nervous System, 2nd edn (pp. 443-494). San Diego: Academic
2. Andriamampandry C, Taleb O, Viry S, Muller C, Paulhumbert J, Gobaille S, Aunis D, Maitre M (2003). Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator c-hydroxybutyrate (GHB). FASEB Journal 17, 1691-1693
3. Björklund A, Dunnet SB, Stenevi U, Lewuis ME, Iversen SD (1980). Reinervation of the denervate striatum by substantia nigra. Brain Research 199, 307-333
4. Bracucci A, Berretta N, Mercuri NB, Francesconi W (2004). Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of substantia nigra. Brain Research 997, 62-66 (Pubitemid 38058535)
5. Brasted PJ, Bussey TJ, Murray EA, Wise SP (2003). Role of the hippocampal system in associative learning beyond the spatial domain. Brain 126, 1202-1223 (Pubitemid 36522962)
6. Brody D, Holtzman D (2006). Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Experimental Neurology 197, 330-340 (Pubitemid 43077140)
7. Bures J, Buresova O, Huston JP (1983). Techniques and Basic Experiments for the Study of Brain and Behaviour. Amsterdam: Elsevier Science Publishers
8. Carter LP, Flores LR, Wu H, Chen W, Unzeitig AW, Coop A, France CP (2003). The role of GABAB receptors in the discriminative stimulus effects of c-hydroxybutyrate in rats: time course and antagonism studies. Journal of Pharmacology and Experimental Therapeutics 665, 668-674 (Pubitemid 36459185)
9. Carter LP, Chen W, Coop A, Koek W, France CP (2006). Discriminative stimulus effects of GHB and GABAB agonists are differentially attenuated by CGP35348. European Journal of Pharmacology 538, 85-93
10. Cash CD (1994). Gamma-hydroxybutyrate: an overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent. Neuroscience and Biobehavioural Reviews 18, 291-304 (Pubitemid 24134495)
11. Castelli MP, Ferraro L, Mocci I, Carta F, Carai MA, Antonelli T, Tanganelli S, Cignarella G, Gessa GL (2003). Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/ hypnotic effect of gamma-hydroxybutyric acid. Journal of Neurochemistry 87, 722-732 (Pubitemid 37310637)
12. Castelli MP, Pibiri F, Carboni G, Piras AP (2004). A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor. CNS Drug Reviews 10, 243-260 (Pubitemid 39391317)
13. Chen J, Sidhu A (2005). The role of D1 dopamine receptors and phospho-ERK in mediating cytotoxicity. Commentary. Neurotoxicology Research 7, 179-181
14. Chiueh CC, Andoh T, Lai AR, Lai E, Krishna G (2000). Neuroprotective strategies in Parkinson's disease: protection against progressive nigral damage induced by free radicals. Neurotoxicology Research 2, 293-310
15. Crawley J (1999). Behavioural phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioural tests. Brain Research 835, 18-26 (Pubitemid 29336546)
16. Crunelli V, Emri A, Leresche N (2006). Untravelling the brain targets of c-hydroxybutyric acid. Current Opinion in Pharmacology 6, 44-52 (Pubitemid 43108841)
17. Davis HP, Baranowski JR, Pulsinelli WA, Volpe BT (1987). Retention of reference memory following ischemic hippocampal damage. Physiology and Behavior 39, 783-786 (Pubitemid 17064413)
18. Degenhardt L, Copeland J, Dillion P (2005). Recent trends in the use of 'club drugs': an Australian review. Substance Use & Misuse 40, 1241-1256
19. Diana M, Mereu G, Mura A, Fadda F, Passino N, Gessa G (1991). Low doses of c-hydroxybutyric acid stimulate the firing rate of dopaminergic neurons in unannesthetized rats. Brain Research 566, 208-211
20. Douma BR, Korte SM, Buwalda B, Fleur SE, Bohus B, Luiten PG (1998). Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning. Psychoneuroendocrinology 23, 33-44 (Pubitemid 28252965)
21. Eichenbaum H (2000). A cortical-hippocampal system for declarative memory. Nature Reviews in Neuroscience 1, 41-50
22. Floresco SB, Seamans JK, Phillips AG (1997). Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay. Journal of Neuroscience 17, 1880-1890 (Pubitemid 27089832)
23. Gallagher M, Rapp PR (1997). The use of animal models to study the effects of aging on cognition. Annals Reviews of Psychology 48, 339-370 (Pubitemid 127485180)
24. Godbout R, Jelenic P, Labrie C, Schmitt M, Bourguignon JJ (1995). Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat. Brain Research 673, 157-160
25. Gould G, Mehta AK, Franzer A, Ticku MK (2003). Quantitative autoradiographic analysis of the new radioligand [3H](2E)-(5-hydroxy-5,7,8,9- tetrahydro-6Hbenzo[ a][7]annulen-6-3 ylidene) ethanoic acid ([3H]NCS- 382) at c-hydroxybutyric acid (GHB) binding sites in rat brain. Brain Research 979, 51-56 (Pubitemid 36792155)
26. Gundersen HJG, Bagger P, Bendsten TF, Evans S, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, et al. (1988). The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. Acta Pathologica, Microbiologica et Immunologica Scandinavica 96, 857-881
27. Hechler V, Gobaille S, Maitre M (1992). Selective distribution pattern of c-hydroxybutyrate receptors in the rat forebrain and midbrain as revealed by quantitative autoradiography. Brain Research 572, 3345-3348
28. Hechler V, Gobaille S, Bourguignon JJ, Mark J, Maitre M (1993). c-hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities. Journal of Pharmacology and Experimental Therapeutics 264, 1406-1414 (Pubitemid 23318639)
29. Hopfer C, Mendelson B, Van Leeuwen JM, Kelly S, Hooks S (2006). Club drug use among youths in treatment for substance abuse. American Journal of Addiction 15, 94-99 (Pubitemid 43207194)
30. Howard SG, Feigenbaum JJ (1997). Effects of c-hydroxybutyrate on central dopamine release in vivo. Biochemical Pharmacology 53, 103-110 (Pubitemid 26419792)
31. Janson AM, Mö ller A (1993). Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat. Neuroscience 57, 931-941 (Pubitemid 23354997)
32. Janus C (2004). Search strategies used by APP transgenic mice during navigation in the morris water maze. Learning and Memory 11, 337-346 (Pubitemid 38697900)
33. Kemmel V, Miehe M, Roussel G, Taleb O, Nail-Boucherie K, Marchand C, Stutz C, Andriamampandry C, Aunis D, Maitre M (2006). Immunohistochemical localization of a GHB receptor-like protein isolated from rat brain. Journal of Comparative Neurology 498, 508-524 (Pubitemid 44232691)
34. Kim HC, Bing G, Jhoo VK, Ko HK, Kim WK, Suh JH, Kim SJ, Kato K, Hong JS (2000). Changes of hippocampal CuZn-superoxide dismutase after kainate treatment in the rat. Brain Research 853, 215-226 (Pubitemid 30035221)
35. Lalonde R, Marchetti N, Strazielle C (2005). Primary neurologic screening and motor coordination of DstdtxJ mutant mice (Dystonia musculorum) with spinocerebellar atrophy. Physiology & Behavior 86, 46-51 (Pubitemid 41316607)
36. Lee I, Kesner RP (2003a). Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay. Behavioral Neuroscience 117, 1044-1053 (Pubitemid 37243786)
37. Lee I, Kesner RP (2003b). Time-Dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory. Journal of Neuroscience 15, 1517-1523 (Pubitemid 36258930)
38. Maitre M (1997). The c-Hydroxybutyrate signalling system in brain: organization and functional implications. Progress in Neurobiology 551, 337-361 (Pubitemid 27143802)
39. Marshall F, Teitelbaum P (1974). Further analysis of sensory inattention flowing lateral hypothalamic damage in rats. Journal of Comparative Physiological Psychology 86, 375-395
40. Martellotta MC, Cossu G, Fattore L, Gessa GL, Fratta W (1998). Intravenous self-administration of gammahydroxybutyric acid in drug-nave mice. European Neuropsychopharmacology 8, 293-296 (Pubitemid 28557023)
41. Matsumura M, Kawashima R, Naito E, Satoh K, Takahashi T, Yanagisawa T, Fukuda H (1996). Changes in rCBF during grasping in humans examined by PET. Neuroreport 7, 749-752 (Pubitemid 26145335)
42. Miettinen R, Sirvio J, Riekkinen Sr. P, Laakso MP, Riekkinen M, Riekkinen P (1993). Neocortical, hippocampal and septal parvalbuminand somatostatincontaining neurons in young and aged rats: correlation with passive avoidance and water maze performance. Neuroscience 53, 367-378 (Pubitemid 23101321)
43. Navarro JF, Pedraza C (1996). An ethopharmacological assessment of the effects of gammahydroxybutyrate on agonistic interactions in male mice. Medical Science Research 24, 817-819 (Pubitemid 27068194)
44. Navarro JF, Pedraza C, Mart́n M, Manzaneque JM, Dávila G, Maldonado E (1998). Tiapride-induced catalepsy is potentiated by gammahydroxybutyric acid administration. Progress in Neuropsychopharmacology & Biological Psychiatry 22, 835-844 (Pubitemid 28396347)
45. Navarro JF, González F, Pedraza C (2007). Acute and subchronic effects of gammahydroxybutyrate (GHB) on isolation-induced aggression in male mice. Methods and Findings in Experimental and Clinical Pharmacology 29, 379-382 (Pubitemid 47597851)
46. Oades RD (1981). Types of memory or attention? Impairment after lesions of the hippocampus and limbic ventral tegmentum. Brain Research Bulletin 18, 533-545
47. Olton DS, Papas BC (1979). Spatial memory and hippocampal function. Neuropsychology 17, 669-682 (Pubitemid 10167907)
48. Ottani A, Saltini F, Bartiromo M, Zaffe D, Botticelli AR, Ferrari A, Bertolini A, Genedani S (2003). Effect of c-hydroxybutyrate in two rat models of focal cerebral damage. Brain Research 896, 181-190 (Pubitemid 37272112)
49. Paxinos G, Watson C (1998). The Rat Brain in Stereotaxic Coordinates, 4th edn. San Diego: Academic Press
50. Pedraza C, Dávila G, Mart́n-López M, Navarro JF (2007). Antiaggressive effects of GHB in male mice: involvement of dopamine D2 receptors. Progress in Neuropsychopharmacology and Biological Psychiatry 31, 337-342 (Pubitemid 46209410)
51. Pistis M, Muntoni AL, Pillilla G, Perra S, Melis M, Gessa GL (2005). Gamma-Hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: evidence for GABAB receptor-mediated effects. Neuroscience 131, 465-474 (Pubitemid 40222453)
52. Raess BU, Tunnicliff G (2002). Abuse potential and toxicology of gamma-hydroxybutyrate. In: Tunnicliff G, Cash CD (Eds), Gamma-Hydroxybutyrate: Molecular, Functional and Clinical Aspects (pp. 188-196). London: Taylor and Francis
53. Schmidt-Mutter C, Muller C, Zwiller J, Gobaille S, MaitreM (1999). Gamma-hydroxybutyrate and cocaine administration increases mRNA expression of dopamine D1 and D2 receptors in rat brain. Neuropsychopharmacology 21, 662-669 (Pubitemid 29486634)
54. Sevack RJ, France CP, Koek W (2004). Neuroleptic-like effects of c-hydroxybutyrate: interactions with haloperidol and dizocilpine. European Journal of Pharmacology 483, 289-293 (Pubitemid 38068412)
55. Sgaravatti AM, Sgarbi MB, Testa CG, Durigon K, Pederzolli CD, Prestes CC, Wyse AT, Wannmacher CM, Wajner M, Dutra-Filho CS (2007). c-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats. Neurochemistry International 50, 564-570 (Pubitemid 46186607)
56. Sicar R, Basak A (2004). Adolescent c-hydroxybutyric acid exposure decreases cortical N-methyl-D-aspartate receptor and impairs spatial learning. Pharmacology Biochemistry and Behavior 79, 701-708 (Pubitemid 39600609)
57. Smith TD, AdamsMM, Gallagher M, Morrison JH, Rapp PR (2000). Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. Journal of Neuroscience 20, 6587-6593
58. Sumnall HS, Woolfall K, Edwards S, Cole JC, Beynon CM (2008). Use, function, and subjective experiences of gamma-hydroxybutyrate (GHB). Drug and Alcohol Dependence 92, 286-290 (Pubitemid 350218199)
59. Touzani K, Puthanveetti SV, Kandel ER (2007). Consolidation of learning strategies during spatial working memory task requires protein synthesis in the prefrontal cortex. Proceedings of the National Academy of Sciences USA 104, 5632-5637 (Pubitemid 47175732)
60. Tremblay H, Godbout R, Girodias V, Schmitt M, Bourguignon JJ (1998). Effects of gamma-hydroxybutyrate on ventral tegmental unit activity in the rat: considerations on REM sleep control. Sleep Research Online 1, 152-158
61. Vergoni VA, Ottani A, Botticelli AR, Zaffe D, Guano L, Loche A, Genedani S, Gessa GL, Bertolini A (2000). Neuroprotective effect of gamma-hydroxybutyrate in transient global cerebral ischemia in the rat. European Journal of Pharmacology 397, 75-84 (Pubitemid 30323813)
62. Whishaw IQ, Rod MR, Auer RN (1994). Behavioral deficits revealed by multiple tests in rats with ischemic damage limited to half of the CA1 sector of the hippocampus. Brain Research Bulletin 34, 283-289
63. Yan XB, Wang SS, Hou HL, Ji R, Zhou JN (2007). Lithium improves the behavioral disorder in rats subjected to transient global cerebral ischemia. Behavioural Brain Research 177, 282-289 (Pubitemid 46149907)