Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: Antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slices

Brain Research Bulletin

Volumn 53, Issue 4, 2000, Pages 373-381

  Rae, Caroline ^a   Lawrance, Megan L ^a   Dias, Leonora S ^a   Provis, Tanya ^a   Bubb, William A ^a   Balcar, Vladimir J ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Amyotrophic lateral sclerosis; Antisense knockout; Glutamate; Glutamate neurotoxicity; Glutamine cycle; Neurodegeneration; Neurotransmitter transport

Indexed keywords

2,4 PYRROLIDINEDICARBOXYLIC ACID; 3,4 METHANOPYRROLIDINE DICARBOXYLATE; ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; BRAIN CORTEX; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; FOREBRAIN; GUINEA PIG; NERVE DEGENERATION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASPARTIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BRAIN; CEREBRAL CORTEX; DICARBOXYLIC ACIDS; FEMALE; GLUTAMIC ACID; GUINEA PIGS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEUROTRANSMITTER AGENTS; NEUROTRANSMITTER UPTAKE INHIBITORS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; THIONUCLEOTIDES;

EID: 0034319176     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00372-5     Document Type: Conference Paper

References (90)

1. Glutamate toxicity in neuron-enriched and neuron-astrocyte co-cultures; Effect of the glutamate uptake inhibitor L-t-2,4-PDC
2. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
3. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
4. 13C-n.m.r. spectroscopy
5. 3H]L-glutamate in cultured fibroblasts
6. High affinity uptake of L-glutamate and L-aspartate by glial cells
7. The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices
8. Stereospecificity of the inhibition of L-glutamate and L-aspartate high affinity uptake in rat brain slices by threo-3-hydroxyaspartate
9. Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system
10. 3H]kainate in sections of rat forebrain
11. Differences between substrate specificities of L-glutamate uptake by neurons and glia, studied in cell lines and primary cultures
12. Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function
13. Amino acid neurotransmitter candidates; Sodium-dependent high affinity uptake by unique synaptosomal fractions
14. Forty years of amino acid transmision in the brain
15. The glutamate transport inhibitor L-t-2,4-PDC indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures
16. Glutamine-A major substrate for nerve endings
17. +-dependent transporter in the forebrain synaptosomes; L-anti,endo-3,4-methanopyrrolidine dicarboxylate
18. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereoisomer
19. Transmitter time course in the synaptic cleft; Its role in the central synaptic function
20. Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts
21. Properties and localization of glutamate tranporters
22. Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation
23. Excitotoxic mechanisms in the pathogenesis of dementia
24. An excitatory amino acid transporter with properties of a ligand-gated chloride channel
25. Glutamate; A neurotransmitter in mammalian brain
26. A stereoselective anomaly in dicarboxylic amino acid transport
27. Cellular distribution and kinetic properties of high affinity glutamate transporter
28. Glutamate translocation of the glutamate transporter EAAC1 occurs within milliseconds
29. ALS-linked Cu/Zn-SOD mutation impairs central synaptic glucose and glutamate transport and exacerbates ischaemic brain injury
30. Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate
31. +-dependent glutamate uptake in rat hippocampal astrocyte cultures
32. Uptake of neurotransmitter candidate glutamate by glia
33. Mini-review. Astrocytes; Glutamate producers for neurons
34. The uptake inhibitor L-t-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus
35. Primary structure and functional characterization of a high-affinity glutamate transporter
36. Autoradiographic studies indicate regional variations in the characteristics of L-glutamate transporters in the rat brain
37. Compilation and analysis of sequences upstream from the translational site in eukaryotic mRNAs
38. Adiabatic pulses for wideband inversion and broadband decoupling
39. The number of glutamate transporter subtype molecules at glutamatergic synapses; Chemical and stereological quantification in young adult rat brain
40. Differential expression of two glial glutamate transporters in the rat brain; Quantitative and immunocytochemical observations
41. 3H]L-aspartate in thaw-mounted sections of frozen rat brain
42. 3H]L-aspartate binding to glutamate transporters in rat brain; Structure-activity studies using L-trans-pyrrolidine-2,4-dicarboxylate (L-t-PDC) and 2-(carboxycyclopropyl)-glycine (CCG)
43. Aberrant RNA processing in a neurodegenerative disease; The cause of absent EAAT2, a glutamate transporter in ALS
44. Unique high affinity system for glycine, glutamic and aspartic acids in central nervous tissue
45. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
46. Glutamate transport in cultures from developing avian cerebellum; Presence of GLT-1 immunoreactivity in Purkinje neurons
47. Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures
48. Protein determination for large numbers of samples
49. The glial glutamate transporters in hyperammonemia and hepatic encephalopathy; Relation to energy metabolism and glutamatergic neurotransmission
50. GLT-1, glial glutamate transporter, is transiently expressed in neurones and develops astrocyte specificity only after midgestation in the ovine fetal brain
51. Altered glutamatergic transmission in neurological disorders; From high extracellular glutamate to excessive synaptic efficacy
52. Group I metabotropic receptor agonist causes neurotoxic lesions in rat hippocampus in vivo
53. A P2 purinoceptor blocker suramin antagonizes NMDA receptors and protects against excitatory behaviour caused by NMDA receptor agonist (RS)-(Tetrazol-5-yl)-glycine in rats
54. Glutamate transporter EAAC1-deficient mice develop dicarboxylic aminoaciduria and behavioural abnormalities but no neurodegeneration
55. Cloning and expression of a rat brain L-glutamate transporter
56. Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture
57. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global ischaemia
58. Review article. The family of sodium-dependent glutamate transporters; A focus on GLT-1/EAAT-2 subtype
59. +-dependent glutamate transporters in the mammalian CNS
60. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
61. Chronic glutamate uptake inhibition produces a model of slow neurotoxicity
62. Localization of glial and neuronal transporters
63. Decreased brain and spinal cord glutamate transport in amyotrophic lateral sclerosis
64. Abnormal amino acid metabolism in amyotrophic lateral sclerosis
65. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
66. Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired
67. Molecular mechanisms of calcium-dependent excitotoxicity
68. Transport and metabolism of glutamate and GABA in neurones and glial cells
69. Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres
70. Quinolinic acid; An endogenous metabolite that produces axon-sparing lesions in rat brain
71. Variant forms of neuronal glutamate transporter sites in Alzheimer disease cerebral cortex
72. Computer-optimized decoupling scheme for wideband applications and low-level operation
73. DL-threo-β-benzyloxyspartate, a potent blocker of excitatory amino acid transporters
74. A phase-cycling algorithm for reducing sidebands in adiabatic decoupling
75. Mitochondrial heterogeneity in the brain at the cellular level
76. +-dependent glutamate/aspartate transporter from rat brain
77. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
78. Review article. On the relationship between extracellular glutamate, hyperexcitation and neurodegeneration, in vivo
79. SOD 1 mutant linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
80. Molecular pharmacology and physiology of glutamate transporters in the central nervous system
81. Contrasting modes of action of methylglutamate deivatives on the excitatory amino acid transporters, EAAT1 and EAAT2
82. The competitive transport inhibitor L-t-PDC triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition
83. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
84. Gradient selection in inverse heteronuclear correlation spectroscopy
85. 3H]α,β-methylene-ATP binding in rat brain
86. Astrocyte metabolism; Glutamate-glutamine cycle