Binding characteristics of γ-hydroxybutyric acid as a weak but selective GABA(B) receptor agonist

European Journal of Pharmacology

Volumn 321, Issue 1, 1997, Pages 67-75

  Mathivet, Pascal ^a   Bernasconi, Raymond ^a   De Barry, Jean ^b   Marescaux, Christian ^a   Bittiger, Helmut ^c  

^a INSERM   (France)

^b CNRS   (France)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Absence seizure; G protein coupled receptor; GABA(B) receptor; GHB ( hydroxybutyric acid); GTP shift

Indexed keywords

3 AMINOPROPANEPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4 HYDROXYBUTYRIC ACID; ARECAIDINE; BACLOFEN; CGP 54626; ETHOSUXIMIDE; GUANYLYLIMIDODIPHOSPHATE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CEREBELLUM; DRUG RECEPTOR BINDING; FEMALE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; ANTICONVULSANTS; BACLOFEN; BINDING, COMPETITIVE; BRAIN CHEMISTRY; ETHOSUXIMIDE; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; GUANYLYL IMIDODIPHOSPHATE; MALE; ORGANOPHOSPHORUS COMPOUNDS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-B; SODIUM OXYBATE; VALPROIC ACID;

EID: 0031577966     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00916-8     Document Type: Article

References (45)

1. B) receptors in cerebral cortex during the estrous cyclic, Brain Res. 640, 33.
2. B) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GHB, J. Pharmacol. Exp. Ther. 264, 1406.
3. Bearden, L.J., O.C. Snead, C.T. Healey and G.V. Pegram, 1980, Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate, Electroencephalogr. Clin. Neurophysiol. 49, 181.
4. Benavides, J., J.F. Rumigny, J.J. Bourguignon, C. Cash, C.G. Wermuth, P. Mandel, G. Vincendon and M. Maitre, 1982, High affinity site for γ-hydroxybutyric acid in rat brain, Life Sci. 30, 953.
5. Bernasconi, R., R.S.G. Jones, H. Bittiger, H.R. Olpe, J. Heid, P. Martin, M. Klein, P. Loo, A. Braunwalder and M. Schmutz, 1986, Does pipecolic acid interact with the central GABA-ergic system?, J. Neural Transm. 67, 175.
6. B receptors, J. Neural Transm. (Suppl.) 35, 155.
7. B receptors, Soc. Neurosci. Abstr. 21, 778.
8. B Receptors in Mammalian Function, eds. N.G. Bowery, H. Bittiger and H.R. Olpe (John Wiley, Chichester) p. 47.
9. B receptors, Pharmacol. Commun. 2, 23.
10. B receptor site distribution in the rat central nervous system, Neuroscience 20, 365.
11. Cash, C.D., 1994, Gammahydroxybutyrate: an overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent, Neurosci. Biobehav. Rev. 18, 4375.
12. 50) of an enzymatic reaction, Biochem. Pharmacol. 22, 3099.
13. B receptors, Naunyn-Schmiedeberg's Arch. Pharmacol. 348, 491.
14. Godschalk, M., M.R. Dzoljic and I.L. Bonta, 1976, Antagonism of gamma-hydroxybutyrate-induced hypersynchronization in the ECoG of the rat by anti-petit mal drugs, Neurosci. Lett. 3, 145.
15. Godschalk, M., M.R. Dzoljic and L. Bonta, 1977, Slow wave sleep and state resembling absence epilepsy induced in the rat by gamma-hydroxybutyrate, Eur. J. Pharmacol. 44, 105.
16. Hechler, V., S. Gobaille and M. Maitre, 1992, Selective pattern of γ-hydroxybutyrate receptors in the rat forebrain and midbrain as revealed by quantitative autoradiography, Brain Res. 572, 345.
17. B sites in rat brain, Nature 290, 149.
18. B receptor binding by guanyl nucleotides, J. Neurochem. 42, 652.
19. B receptors in mouse cerebral cortex, cerebellum and whole brain, Gen. Pharmacol. 24, 1533.
20. Ishige, K., M. Aizawa, Y. Ito and H. Fukuda, 1996, γ-Butyrolactone-induced absence-like seizures increase nuclear CRE and AP-1 DNA-binding activities in mouse brain, Neuropharmacology 35, 45.
21. B receptor in cultured cerebellar granule cells, J. Neurochem, 65, 75.
22. Kaufman, E. and T. Nelson, 1983, Inhibition of gamma-hydroxybutyrate dehydrogenase by aromatic or branched-chain acids, J. Neurochem. 41, S139.
23. + dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway. Neurochem. Res. 16, 965.
24. Maitre, M., V. Hechler, P. Vayer, S. Gorbaille, C.D. Cash, M. Schmitt and J.J. Bourguignon, 1990, A specific γ-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties, J. Pharmacol. Exp. Ther. 225, 657.
25. B receptor antagonists: potential new-antiabsence drugs, J. Neural Transm. (Suppl.) 35, 179.
26. B receptors are involved in the occurrence of absence seizures in rats, Pharmacol. Commun. 2, 57.
27. B-receptor binding sites in genetic absence epilepsy rats from Strasbourg (GAERS) and in non-epileptic control rats, in: Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects, eds. A. Malafosse, P. Genton, E. Hirsch, C. Marescaux, D. Broglin and R. Bernasconi (John Libbey, London) p. 177.
28. B ligand binding by the GTP analogue Gpp(NH)p, Mol. Brain Res. 42, 18.
29. B and γ-hydroxybutyric acid (GHB) receptors, Pharmacol. Commun. 8, 209.
30. Ratomponirina, C., Y. Hodé, V. Hechler and M. Maitre, 1995, γ-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin, Neurosci. Lett. 189, 51.
31. Rumigny, J.F., M. Maitre, C.D. Cash and P. Mandel, 1980, Specific and non-specific succinic semialdehyde reductases from rat brain: isolation and properties, FEBS Lett. 117, 111.
32. Snead, O.C., 1988, Gamma-hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models, Epilepsia 29, 361.
33. Snead, O.C., 1991, The γ-hydroxybutyrate model of absence seizures: correlation of regional brain levels of γ-hydroxybutyric acid and γ-butyrolactone with spike and wave discharges, Neuropharmacology 30, 161.
34. B receptor mediated mechanisms in experimental absence seizures in rat, Pharmacol. Commun, 2, 63.
35. B-mediated mechanisms in experimental generalized absence seizures, Eur. J. Pharmacol. 213, 343.
36. B binding sites: relation to the development of experimental absence seizures, Brain Res. 659, 147.
37. B receptor, Soc. Neurosci. Abstr. 21, 1477.
38. Vayer, P., P. Mandel and M. Maitre, 1985a, Conversion of γ-hydroxybutyrate to γ-aminobutyrate in vitro, J. Neurochem. 45, 810.
39. m aldehyde reductase in the degradation of endogenous gamma-hydroxybutyrate from rat brain, FEBS Lett. 190, 55.
40. Vayer, P., P. Mandel and M. Maitre, 1987, Gamma-hydroxybutyrate, a possible neurotransmitter, Life Sci. 41, 1547.
41. Vayer, P., J.D. Ehrhardt, S. Gobaille, P. Mandel and M. Maitre, 1988, Gamma-hydroxybutyrate distribution and turnover rates in discrete brain regions of the rat, Neurochem. Int. 12, 53.
42. B antagonist CGP 35348 antagonizes the effects of baclofen, γ-butyrolactone and HA 966 on rat striatal dopamine synthesis, Naunyn-Schmiedeberg's Arch. Pharmacol. 343, 173.
43. B receptor-mediated hyperpolarization, Neuroscience 66, 133.
44. B receptors, Eur. J. Pharmacol. 212, 291.
45. Xie, X. and T.G. Smart, 1992b, γ-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices, Eur. J. Pharmacol. 223, 193.