Endogenous γ-aminobutyric acid (GABA)A receptor active neurosteroids and the sedative/hypnotic action of γ-hydroxybutyric acid (GHB): A study in GHB-S (sensitive) and GHB-R (resistant) rat lines

Neuropharmacology

Volumn 49, Issue 1, 2005, Pages 48-58

  Barbaccia, Maria Luisa ^a   Carai, Mauro A M ^b   Colombo, Giancarlo ^c   Lobina, Carla ^b   Purdy, Robert H ^d   Gessa, Gian Luigi ^b,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c CNR   (Italy)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Hydroxybutyric acid; GABAA GABAB receptor; GHB S GHB R rat; Loss of righting reflex; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 HYDROXYBUTYRIC ACID; ELTANOLONE; HYPNOTIC AGENT; NEUROSTEROID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RIGHTING REFLEX; SEDATION;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN; BRAIN CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROXYBUTYRATES; HYPNOTICS AND SEDATIVES; MALE; PREGNANES; RADIOIMMUNOASSAY; RATS; REACTION TIME; RECEPTORS, GABA-A; REFLEX; SEX FACTORS; TIME FACTORS;

EID: 21344436812     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.01.026     Document Type: Article

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