The drug of abuse γ-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-mediated uptake and inhibition

Drug Metabolism and Disposition

Volumn 37, Issue 7, 2009, Pages 1404-1410

  Cui, Dapeng ^a   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ALPHA CYANO 4 HYDROXYCINNAMIC ACID; BUTYRIC ACID; IBUPROFEN; KETOPROFEN; LACTIC ACID; LUTEOLIN; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; NAPROXEN; PHLORETIN; PROBENECID; PYRUVIC ACID; SODIUM; SODIUM COUPLED MONOCARBOXYLATE TRANSPORTER 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG INHIBITION; DRUG TRANSPORT; DRUG UPTAKE; GENE EXPRESSION; GENETIC TRANSFECTION; IC 50; MICHAELIS MENTEN KINETICS; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID FOLLICLE CELL; TRANSPORT KINETICS; WESTERN BLOTTING;

ANIMALS; BUTYRATES; CELLS, CULTURED; HYDROGEN-ION CONCENTRATION; HYDROXYBUTYRATES; LACTATES; LACTIC ACID; MEMBRANE POTENTIALS; MONOCARBOXYLIC ACID TRANSPORTERS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SODIUM; SODIUM OXYBATE; SYMPORTERS;

RATTUS;

EID: 67649397435     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027169     Document Type: Article

References (39)

1. Ambesi-Impiombato FS, Parks LA, and Coon HG (1980) Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc Natl Acad Sci U S A 77:3455-3459. (Pubitemid 10012253)
2. Arena C and Fung HL (1980) Absorption of sodium γ-hydroxybutyrate and its prodrug gammabutyrolactone: relationship between in vitro transport and in vivo absorption. J Pharm Sci 69:356-358. (Pubitemid 10121447)
3. Barac-Nieto M, Murer H, and Kinne R (1980) Lactate-sodium cotransport in rat renal brush border membranes. Am J Physiol 239:F496-F506. (Pubitemid 11241516)
4. Beguinot F, Beguinot L, Tramontano D, Duilio C, Formisano S, Bifulco M, Ambesi-Impiombato FS, and Aloj SM (1987) Thyrotropin regulation of membrane lipid fluidity in the FRTL-5 thyroid cell line: its relationship to cell growth and functional activity. J Biol Chem 262:1575-1582.
5. Choi JS, Jin MJ, and Han HK (2005) Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs. J Pharm Pharmacol 57:1185-1189. (Pubitemid 41391777)
6. Fanelli A, Grollman EF, Wang D, and Philp NJ (2003) MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells. Am J Physiol Endocrinol Metab 285:E1223-E1229. (Pubitemid 37464372)
7. Ferrara SD, Zotti S, Tedeschi L, Frison G, Castagna F, Gallimberti L, Gessa GL, and Palatini P (1992) Pharmacokinetics of γ-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses. Br J Clin Pharmacol 34:231-235.
8. Frank H, Gröger N, Diener M, Becker C, Braun T, and Boettger T (2008) Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J Biol Chem 283:24729-24737.
9. Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, and Prasad PD (2008) Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J 10:193-199.
10. Gopal E, Fei YJ, Miyauchi S, Zhuang L, Prasad PD, and Ganapathy V (2005) Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. Biochem J 388:309-316. (Pubitemid 40732959)
11. +-coupled transport of lactate. J Biol Chem 279:44522-44532.
12. Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB, and Ganapathy V (2007a) Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharm Res 24:575-584. (Pubitemid 46295162)
13. Gopal E, Umapathy NS, Martin PM, Ananth S, Gnana-Prakasam JP, Becker H, Wagner CA, Ganapathy V, and Prasad PD (2007b) Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. Biochim Biophys Acta 1768:2690-2697. (Pubitemid 350060863)
14. Halestrap AP and Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343 (Pt 2):281-299. (Pubitemid 29511759)
15. Itagaki S, Gopal E, Zhuang L, Fei YJ, Miyauchi S, Prasad PD, and Ganapathy V (2006) Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8). Pharm Res 23:1209-1216. (Pubitemid 43946143)
16. Iwanaga T, Takebe K, Kato I, Karaki S, and Kuwahara A (2006) Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Biomed Res 27:243-254. (Pubitemid 44768653)
17. Lettieri JT and Fung HL (1979) Dose-dependent pharmacokinetics and hypnotic effects of sodium γ-hydroxybutyrate in the rat. J Pharmacol Exp Ther 208:7-11. (Pubitemid 9154069)
18. Maitre M (1997) The γ-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol 51:337-361. (Pubitemid 27143802)
19. Mamelak M, Scharf MB, and Woods M (1986) Treatment of narcolepsy with gammahydroxybutyrate: a review of clinical and sleep laboratory findings. Sleep 9:285-289. (Pubitemid 18008511)
20. +-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. J Neurochem 98:279-288.
21. Mason PE and Kerns WP 2nd (2002) Gamma hydroxybutyric acid (GHB) intoxication. Acad Emerg Med 9:730-739. (Pubitemid 34747263)
22. Mengual R, Claude-Schlageter MH, Poiree JC, Yagello M, and Sudaka P (1989) Characterization of sodium and pyruvate interactions of the two carrier systems specific of mono- and di- or tricarboxylic acids by renal brush-border membrane vesicles. J Membr Biol 108:197-205. (Pubitemid 19150487)
23. Morris ME and Felmlee MA (2008) Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse γ-hydroxybutyric acid. AAPS J 10:311-321.
24. Morris ME, Hu K, and Wang Q (2005) Renal clearance of γ-hydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy. J Pharmacol Exp Ther 313:1194-1202. (Pubitemid 40727022)
25. Palatini P, Tedeschi L, Frison G, Padrini R, Zordan R, Orlando R, Gallimberti L, Gessa GL, and Ferrara SD (1993) Dose-dependent absorption and elimination of γ-hydroxybutyric acid in healthy volunteers. Eur J Clin Pharmacol 45:353-356. (Pubitemid 23338545)
26. Park JY, Helm JF, Zheng W, Ly QP, Hodul PJ, Centeno BA, and Malafa MP (2008) Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. Pancreas 36:e32-e39. (Pubitemid 351591592)
27. +/ monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. Proc Natl Acad Sci U S A 103:7270-7275.
28. Poldrugo F and Addolorato G (1999) The role of γ-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies. Alcohol Alcohol 34:15-24. (Pubitemid 29062746)
29. Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, and Pourcher T (2002) Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes. J Clin Endocrinol Metab 87:3500-3503. (Pubitemid 34816408)
30. Shitara Y, Sato H, and Sugiyama Y (2005) Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. Annu Rev Pharmacol Toxicol 45:689-723. (Pubitemid 40261822)
31. Spanier JA and Drewes LR (2007). Monocarboxylate transporters, in Drug Transporters: Molecular Characterization and Role in Drug Disposition (You G and Morris ME, eds) pp 147-170, Wiley-Interscience, Hoboken.
32. Srinivas SR, Gopal E, Zhuang L, Itagaki S, Martin PM, Fei YJ, Ganapathy V, and Prasad PD (2005) Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Biochem J 392:655-664. (Pubitemid 43022746)
33. +-coupled transporter for short-chain fatty acids (slc5a8) in the intestine and kidney of the mouse. Biomed Res 26:213-221.
34. Tamai I, Takanaga H, Maeda H, Sai Y, Ogihara T, Higashida H, and Tsuji A (1995) Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem Biophys Res Commun 214:482-489.
35. Tedeschi L, Carai MA, Frison G, Favretto D, Colombo G, Ferrara SD, and Gessa GL (2003) Endogenous γ-hydroxybutyric acid is in the rat, mouse and human gastrointestinal tract. Life Sci 72:2481-2488. (Pubitemid 36316044)
36. Wang Q, Darling IM, and Morris ME (2006) Transport of γ-hydroxybutyrate in rat kidney membrane vesicles: role of monocarboxylate transporters. J Pharmacol Exp Ther 318:751-761. (Pubitemid 44061250)
37. Wang Q and Morris ME (2007) Flavonoids modulate monocarboxylate transporter-1-mediated transport of γ-hydroxybutyrate in vitro and in vivo. Drug Metab Dispos 35:201-208. (Pubitemid 46151668)
38. Wang Q, Wang X, and Morris ME (2008) Effects of L-lactate and D-mannitol on γ-hydroxybutyrate toxicokinetics and toxicodynamics in rats. Drug Metab Dispos 36:2244-2251.
39. Wong CG, Gibson KM, and Snead OC 3rd (2004) From the street to the brain: neurobiology of the recreational drug γ-hydroxybutyric acid. Trends Pharmacol Sci 25:29-34.