γ-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 1, 2004, Pages 172-179

  Schweitzer, Paul ^a   Roberto, Marisa ^a   Madamba, Samuel G ^a   Siggins, George Robert ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 HYDROXYBUTYRIC ACID; 5 HYDROXY 5,7,8,9 TETRAHYDRO 6H BENZO[A][7]ANNULEN 6 YLIDENE ETHANOIC ACID; BACLOFEN; BARIUM; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; G PROTEIN COUPLED RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; NCS 382; UNCLASSIFIED DRUG;

ABSENCE; ALCOHOLISM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABUSE; DRUG EFFECT; H CURRENT; HIPPOCAMPUS; HYPERPOLARIZATION; INTOXICATION; MALE; MEMBRANE STEADY POTENTIAL; NONHUMAN; POSTSYNAPTIC CONDUCTANCE; POSTSYNAPTIC INHIBITION; POTASSIUM CURRENT; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP;

ANIMALS; BACLOFEN; BARIUM; GABA AGONISTS; POTASSIUM; PROTONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; SODIUM OXYBATE; SYNAPTIC TRANSMISSION;

EID: 4644248656     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.069534     Document Type: Article

References (41)

1. Bal T and McCormick DA (1997) Synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current Ih. J Neurophysiol 77:3145-3156.
2. Banerjee PK, Hirsch E, and Snead OC 3rd (1993) Gamma-hydroxybutyric acid induced spike and wave discharges in rats: relation to high-affinity [3H]gamma-hydroxybutyric acid binding sites in the thalamus and cortex. Neuroscience 56:11-21.
3. B receptors. J Neural Transm 35:155-177.
4. Bernasconi R, Mathivet P, Bischoff S, and Marescaux C (1999) Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential? Trends Pharmacol Sci 20:135-141.
5. Berton F, Brancucci A, Beghè F, Cammalleri M, Demuro A, Francesconi W, and Gessa GL (1999) Gamma-hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices. Eur J Pharmacol 380:109-116.
6. Brancucci A, Berretta N, Mercuri NB, and Francesconi W (2004) Presynaptic modulation of spontaneous inhibitory postsynaptic currents by gamma-hydroxybutyrate in the substantia nigra pars compacta. Neuropsychopharmacology 29:537-543.
7. A-mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus. Neuropsychopharmacology 27:960-969.
8. B receptors. Neurosci Lett 216:121-124.
9. B receptors. Naunyn-Schmiedeberg's Arch Pharmacol 348:491-497.
10. Feigenbaum JJ and Howard SG (1996) Gamma hydroxybutyrate is not a GABA agonist. Prog Neurobiol 50:1-7.
11. Gallimberti L, Spella MR, Soncini CA, and Gessa GL (2000) Gamma-hydroxybutyric acid in the treatment of alcohol and heroin dependence. Alcohol 20:257-262.
12. Galloway GP, Frederick SL, Staggers FE Jr, Gonzales M, Stalcup SA, and Smith DE (1997) Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence. Addiction 92:89-96.
13. Gervasi N, Monnier Z, Vincent P, Paupardin-Tritsch D, Hughes SW, Crunelli V, and Leresche N (2003) Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. J Neurosci 23:11469-11478.
14. Halliwell JV and Adams PR (1982) Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res 250:71-92.
15. Hechler V, Weissmann D, Mach E, Pujol JF, and Maitre M (1987) Regional distribution of high-affinity gamma-[3H]hydroxybutyrate binding sites as determined by quantitative autoradiography. J Neurochem 49:1025-1032.
16. B receptors in mouse neocortical neurons. Cereb Cortex 11:424-429.
17. Jiang ZG, Pessia M, and North RA (1993) Dopamine and baclofen inhibit the hyperpolarization-activated cation current in rat ventral tegmental neurones. J Physiol (Lond) 462:753-764.
18. Johnston D and Brown TH (1983) Interpretation of voltage-clamp measurements in hippocampal neurons. J Neurophysiol 50:464-486.
19. Kleinschmidt S, Schellhase C, and Mertzlufft F (1999) Continuous sedation during spinal anaesthesia: gamma-hydroxybutyrate vs. propofol. Eur J Anaesthesiol 16:23-30.
20. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19:687-695.
21. Maccaferri G, Mangoni M, Lazzari A, and DiFrancesco D (1993) Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells. J Neurophysiol 69:2129-2136.
22. B receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons. J Pharmacol Exp Ther 287:261-265.
23. Maitre M (1997) The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol 51:337-361.
24. Maitre M, Hechler V, Vayer P, Gobaille S, Cash CD, Schmitt M, and Bourguignon JJ (1990) A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties. J Pharmacol Exp Ther 255:657-663.
25. B receptor agonist. Eur J Pharmacol 321:67-75.
26. McCormick DA and Contreras D (2001) On the cellular and network bases of epileptic seizures. Annu Rev Physiol 63:815-846.
27. McCormick DA and Pape HC (1990) Properties of a hyperpolarization- activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol (Lond) 431:291-318.
28. Muller C, Viry S, Miehe M, Andriamampandry C, Aunis D, and Maitre M (2002) Evidence for a gamma-hydroxybutyrate (GHB) uptake by rat brain synaptic vesicles. J Neurochem 80:899-904.
29. Ng GY, Bertrand S, Sullivan R, Ethier N, Wang J, Yergey J, Belley M, Trimble L, Bateman K, Alder L, et al. (2001) Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Mol Pharmacol 59:144-152.
30. Pape HC (1996) Queer current and pacemaker: the hyperpolarization- activated cation current in neurons. Annu Rev Physiol 58:299-327.
31. Rolls ET (2000) Memory systems in the brain. Annu Rev Psychol 51:599-630.
32. Schweitzer P, Madamba SG, Champagnat J, and Siggins GR (1993) Somatostatin inhibition of hippocampal CA1 pyramidal neurons: mediation by arachidonic acid and its metabolites. J Neurosci 13:2033-2049.
33. Snead OC 3rd (1996) Presynaptic GABAB- and gamma-hydroxybutyric acid-mediated mechanisms in generalized absence seizures. Neuropharmacology 35:359-367.
34. B receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J Neurosci 16:6374-6385.
35. Surges R, Freiman TM, and Feuerstein TJ (2003) Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells. Epilepsia 44:150-156.
36. + (GIRK) currents in dendrites of rat neocortical pyramidal cells. J Physiol (Lond) 517:385-390.
37. Takigawa T and Alzheimer C (2003) Interplay between activation of GIRK current and deactivation of Ih modifies temporal integration of excitatory input in CA1 pyramidal cells. J Neurophysiol 89:2238-2244.
38. Watts AE, Williams JT, and Henderson G (1996) Baclofen inhibition of the hyperpolarization-activated cation current, Ih, in rat substantia nigra zona compacta neurons may be secondary to potassium current activation. J Neurophysiol 76:2262-2270.
39. Williams SR, Turner JP, and Crunelli V (1995) Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB, receptor-mediated hyperpolarization. Neuroscience 66:133-141.
40. Xie X and Smart TG (1992a) Gamma-hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors. Eur J Pharmacol 212:291-294.
41. Xie X and Smart TG (1992b) Gamma-hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices. Eur J Pharmacol 223:193-196.