Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice

European Journal of Neuroscience

Volumn 18, Issue 10, 2003, Pages 2722-2730

  Kaupmann, Klemens ^a   Cryan, John F ^a   Wellendorph, Petrine ^b   Mombereau, Cedric ^a   Sansig, Gilles ^a   Klebs, Klaus ^a   Schmutz, Markus ^a   Froestl, Wolfgang ^a   Van Der Putten, Herman ^a   Mosbacher, Johannes ^a   Bräuner Osborne, Hans ^b   Waldmeier, Peter ^a   Bettler, Bernhard ^c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Pharmazentrum   (Switzerland)

Author keywords

Delta waves; Dopamine; Drug of abuse; Hypolocomotion; Hypothermia

Indexed keywords

2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL GAMMA HYDROXYBUTYRATE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 HYDROXYBUTYRIC ACID; 6,7,8,9 TETRAHYDRO 5 HYDROXY 5H BENZOCYCLOHEPT 6 YLIDENEACETIC ACID; [3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]CYCLOHEXYLMETHYL PHOSPHINIC ACID; ACETIC ACID DERIVATIVE; CGP54626; FUSED ALICYCLIC AROMATIC COMPOUND; GABAERGIC RECEPTOR AFFECTING AGENT; GAMMA BUTYROLACTONE; GUANINE NUCLEOTIDE BINDING PROTEIN; NCS 382; NEUROTRANSMITTER; PHENOL DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CONTROLLED STUDY; CORPUS STRIATUM; DELTA RHYTHM; DOPAMINE METABOLISM; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HYPOTHERMIA; LOCOMOTION; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

4-BUTYROLACTONE; ADJUVANTS, ANESTHESIA; ANIMALS; ANTICONVULSANTS; AUTORADIOGRAPHY; BACLOFEN; BEHAVIOR, ANIMAL; BENZOCYCLOHEPTENES; BINDING, COMPETITIVE; BODY WEIGHT; BRAIN; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROXYPHENYLALANINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROCHEMISTRY; ELECTROENCEPHALOGRAPHY; GAMMA-AMINOBUTYRIC ACID; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOTOR ACTIVITY; ORGANOPHOSPHORUS COMPOUNDS; PHENOLS; RADIOLIGAND ASSAY; RECEPTORS, GABA-B; SODIUM OXYBATE; TIME FACTORS;

EID: 10744226168     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2003.03013.x     Document Type: Article

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