Conformationally locked nucleosides. Synthesis and stereochemical assignments of 2'-C,4'-C-bridged bicyclonucleosides

Tetrahedron

Volumn 55, Issue 25, 1999, Pages 7707-7724

  Wang, Guangyi ^a   Girardet, Jean Luc ^a   Gunic, Esmir ^a  

^a Valeant Pharmaceuticals International   (United States)

Author keywords

Carbohydrates; Nucleosides; Stereochemistry; X ray crystallography

Indexed keywords

2',2 O DIDEHYDRO 1 ALPHA METHYL 3,5 O (1,1,3,3 TETRAISOPROPYL 1,3 DISILOXANEDIYL)RIBOFURANOSE; BICYCLO COMPOUND; BICYCLONUCLEOSIDE; NUCLEOSIDE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DERIVATIZATION; DRUG SYNTHESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0033581002     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(99)00394-4     Document Type: Article

References (22)

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22. Tables of the crystal data and structure refinements, atomic coordinates, bond lengths and angles, anisotropic displacement parameters, hydrogen coordinates and isotopic displacement parameters, and torsion angles were deposited at the Cambridge Crystallographic Data Centre. The crystal structures of 32 and 20 shown in Fig 1. were randomly selected from two conformers of 32 and four conformers of 20, respectively.