Antimicrobial anxiety: The impact of stress on antimicrobial immunity

Journal of Leukocyte Biology

Volumn 88, Issue 2, 2010, Pages 263-277

  Radek, Katherine A ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; Antimicrobial peptide; Catecholamines; Glucocorticoids; Leukocytes; Neuroimmunology

Indexed keywords

HEAT SHOCK PROTEIN;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BACTERIAL VIRULENCE; ENVIRONMENTAL FACTOR; EPITHELIUM CELL; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IMMUNOMODULATION; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE; MAST CELL; NERVOUS SYSTEM; NEUROIMMUNOLOGY; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRESS; ANXIETY; BACTERIUM; IMMUNOLOGY; MENTAL STRESS;

ANXIETY; BACTERIA; HUMANS; IMMUNITY, INNATE; STRESS, PSYCHOLOGICAL;

EID: 77956415501     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1109740     Document Type: Review

References (176)

1. Locke, S. E. (1982) Stress, adaptation, and immunity: studies in humans. Gen. Hosp. Psychiatry 4, 49-58.
2. Fox, B. H. (1978) Premorbid psychological factors as related to cancer incidence. J. Behav. Med. 1, 45-133.
3. Haggerty, R. J. (1983) Breaking the link between stress and illness in children. What role can physicians play? Postgrad. Med. 74, 287-291, 294-295.
4. Koehler, T., Weber, D. (1992) Psychophysiological reactions of patients with atopic dermatitis. J. Psychosom. Res. 36, 391-394.
5. Garrett, V. D., Brantley, P. J., Jones, G. N., McKnight, G. T. (1991) The relation between daily stress and Crohn's disease. J. Behav. Med. 14, 87-96.
6. Buske-Kirschbaum, A., Gierens, A., Hollig, H., Hellhammer, D. H. (2002) Stress-induced immunomodulation is altered in patients with atopic dermatitis. J. Neuroimmunol. 129, 161-167. (Pubitemid 34874921)
7. Duffy, L. C., Zielezny, M. A., Marshall, J. R., Byers, T. E., Weiser, M. M., Phillips, J. F., Calkins, B. M., Ogra, P. L., Graham, S. (1991) Relevance of major stress events as an indicator of disease activity prevalence in inflammatory bowel disease. Behav. Med. 17, 101-110.
8. Garg, A., Chren, M. M., Sands, L. P., Matsui, M. S., Marenus, K. D., Feingold, K. R., Elias, P. M. (2001) Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch. Dermatol. 137, 53-59.
9. Olff, M. (1999) Stress, depression and immunity: the role of defense and coping styles. Psychiatry Res. 85, 7-15.
10. Brogden, K. A., Guthmiller, J. M., Salzet, M., Zasloff, M. (2005) The nervous system and innate immunity: the neuropeptide connection. Nat. Immunol. 6, 558-564.
11. Troisi, A. (2001) Gender differences in vulnerability to social stress: a Darwinian perspective. Physiol. Behav. 73, 443-449.
12. Ursin, H., Eriksen, H. R. (2004) The cognitive activation theory of stress. Psychoneuroendocrinology 29, 567-592.
13. Herman, J. P., Cullinan, W. E. (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 20, 78-84. (Pubitemid 27050702)
14. Dantzer, R. (2004) Cytokine-induced sickness behavior: a neuroimmune response to activation of innate immunity. Eur. J. Pharmacol. 500, 399-411.
15. Kinnman, J., Fryden, A., Eriksson, S., Moller, E., Link, H. (1981) Tuberculous meningitis: immune reactions within the central nervous system. Scand. J. Immunol. 13, 289-296.
16. Cross, R. J., Jackson, J. C., Brooks, W. H., Sparks, D. L., Markesbery, W. R., Roszman, T. L. (1986) Neuroimmunomodulation: impairment of humoral immune responsiveness by 6-hydroxydopamine treatment. Immunology 57, 145-152.
17. Cannon, W. (1929) Bodily Changes in Pain, Hunger, Fear, and Rage, New York, NY, USA, Appleton.
18. Milligan, E. D., Nguyen, K. T., Deak, T., Hinde, J. L., Fleshner, M., Watkins, L. R., Maier, S. F. (1998) The long term acute phase-like responses that follow acute stressor exposure are blocked by α-melanocyte stimulating hormone. Brain Res. 810, 48-58. (Pubitemid 29003389)
19. Maier, S. F., Watkins, L. R. (1998) Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol. Rev. 105, 83-107.
20. Fulford, A. J., Harbuz, M. S. (2005) An introduction to the HPA. In Handbook of Stress and the Brain (T. Steckler, N. H. Kalin, J. M. H. M. Reul, eds.), Amsterdam, Elsevier, 43-66.
21. Kushner, I. (1993) Regulation of the acute phase response by cytokines. Perspect. Biol. Med. 36, 611-622.
22. Baumann, H., Gauldie, J. (1994) The acute phase response. Immunol. Today 15, 74-80.
23. Grando, S. A., Pittelkow, M. R., Schallreuter, K. U. (2006) Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance. J. Invest. Dermatol. 126, 1948-1965.
24. Qiu, Y., Peng, Y., Wang, J. (1996) Immunoregulatory role of neurotransmitters. Adv. Neuroimmunol. 6, 223-231.
25. Venter, J. C., Fraser, C. M., Kerlavage, A. R., Buck, M. A. (1989) Molecular biology of adrenergic and muscarinic cholinergic receptors. A perspective. Biochem. Pharmacol. 38, 1197-1208.
26. Saeed, R. W., Varma, S., Peng-Nemeroff, T., Sherry, B., Balakhaneh, D., Huston, J., Tracey, K. J., Al-Abed, Y., Metz, C. N. (2005) Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J. Exp. Med. 201, 1113-1123.
27. Pavlov, V. A., Ochani, M., Gallowitsch-Puerta, M., Ochani, K., Huston, J. M., Czura, C. J., Al-Abed, Y., Tracey, K. J. (2006) Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc. Natl. Acad. Sci. USA 103, 5219-5223.
28. Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Susarla, S., Czura, C. J., Tracey, K. J. (2002) Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J. Vasc. Surg. 36, 1231-1236.
29. Tajima, T., Endo, H., Suzuki, Y., Ikari, H., Gotoh, M., Iguchi, A. (1996) Immobilization stress-induced increase of hippocampal acetylcholine and of plasma epinephrine, norepinephrine and glucose in rats. Brain Res. 720, 155-158. (Pubitemid 26179822)
30. Baerwald, C., Graefe, C., Muhl, C., Von Wichert, P., Krause, A. (1992) β 2-Adrenergic receptors on peripheral blood mononuclear cells in patients with rheumatic diseases. Eur. J. Clin. Invest. 22 (Suppl. 1), 42-46.
31. Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C. J., Tracey, K. J. (2003) Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation. Nature 421, 384-388.
32. Ado, A. D., Goldstein, M. M., Kravchenko, S. A., Fominova, T. I. (1986) M-cholinergic receptors in mice B-lymphocytes in the process of immune response. Allergol. Immunopathol. (Madr.) 14, 237-239.
33. Fedoseev, G. B., Zhikharev, S. S., Kotenko, T. V., Subbotina, T. F. (1984) Mechanisms of changes in adrenoreceptor activity of leukocytes during immune stimulation. Hum. Physiol. 10, 102-104.
34. Elenkov, I. J., Wilder, R. L., Chrousos, G. P., Vizi, E. S. (2000) The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol. Rev. 52, 595-638.
35. Besedovsky, H. O., del Rey, A., Sorkin, E., Da Prada, M., Keller, H. H. (1979) Immunoregulation mediated by the sympathetic nervous system. Cell. Immunol. 48, 346-355.
36. Smith, E. M., Blalock, J. E. (1988) A molecular basis for interactions between the immune and neuroendocrine systems. Int. J. Neurosci. 38, 455-464.
37. Besedovsky, H., Sorkin, E., Keller, M., Muller, J. (1975) Changes in blood hormone levels during the immune response. Proc. Soc. Exp. Biol. Med. 150, 466-470.
38. Bjornsson, G. L., Thorsteinsson, L., Gudmundsson, K. O., Jonsson Jr., H., Gudmundsson, S., Gudbjornsson, B. (2007) Inflammatory cytokines in relation to adrenal response following total hip replacement. Scand. J. Immunol. 65, 99-105.
39. Hadden, J. W., Hadden, E. M., Middleton Jr., E. (1970) Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. Cell. Immunol. 1, 583-595.
40. Tracey, K. J. (2002) The inflammatory reflex. Nature 420, 853-859.
41. Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., Tracey, K. J. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458-462. (Pubitemid 30367422)
42. Voice, J. K., Grinninger, C., Kong, Y., Bangale, Y., Paul, S., Goetzl, E. J. (2003) Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice. J. Immunol. 170, 308-314. (Pubitemid 36026154)
43. Scicchitano, R., Stanisz, A. M., Payan, D. G., Kiyono, H., McGhee, J. R., Bienenstock, J. (1987) Expression of substance P and somatostatin receptors on a T helper cell line. Adv. Exp. Med. Biol. 216A, 185-190.
44. Aune, T. M., McGrath, K. M., Sarr, T., Bombara, M. P., Kelley, K. A. (1993) Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. J. Immunol. 151, 1175-1183.
45. Hellstrand, K., Hermodsson, S. (1993) Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes. Scand. J. Immunol. 37, 7-18.
46. Vizi, E. S., Elenkov, I. J. (2002) Nonsynaptic noradrenaline release in neuro-immune responses. Acta Biol. Hung. 53, 229-244.
47. Lorton, D., Lubahn, C., Felten, S. Y., Bellinger, D. (1997) Norepinephrine content in primary and secondary lymphoid organs is altered in rats with adjuvant-induced arthritis. Mech. Ageing Dev. 94, 145-163.
48. Romano, T. A., Felten, S. Y., Olschowka, J. A., Felten, D. L. (1994) Noradrenergic and peptidergic innervation of lymphoid organs in the beluga, Delphinapterus leucas: an anatomical link between the nervous and immune systems. J. Morphol. 221, 243-259.
49. Steinman, L. (2004) Elaborate interactions between the immune and nervous systems. Nat. Immunol. 5, 575-581.
50. Kimyai-Asadi, A., Usman, A. (2001) The role of psychological stress in skin disease. J. Cutan. Med. Surg. 5, 140-145.
51. Denda, M., Tsuchiya, T., Hosoi, J., Koyama, J. (1998) Immobilization-induced and crowded environment-induced stress delay barrier recovery in murine skin. Br. J. Dermatol. 138, 780-785.
52. Denda, M., Tsuchiya, T., Elias, P. M., Feingold, K. R. (2000) Stress alters cutaneous permeability barrier homeostasis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R367-R372.
53. Braff, M. H., Di Nardo, A., Gallo, R. L. (2005) Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies. J. Invest. Dermatol. 124, 394-400.
54. Aberg, K. M., Man, M. Q., Gallo, R. L., Ganz, T., Crumrine, D., Brown, B. E., Choi, E. H., Kim, D. K., Schroder, J. M., Feingold, K. R., Elias, P. M. (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J. Invest. Dermatol. 128, 917-925.
55. Choi, E. H., Brown, B. E., Crumrine, D., Chang, S., Man, M. Q., Elias, P. M., Feingold, K. R. (2005) Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. J. Invest. Dermatol. 124, 587-595.
56. Choi, E. H., Demerjian, M., Crumrine, D., Brown, B. E., Mauro, T., Elias, P. M., Feingold, K. R. (2006) Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R1657-R1662.
57. Singaram, C., Sengupta, A., Stevens, C., Spechler, S. J., Goyal, R. K. (1991) Localization of calcitonin gene-related peptide in human esophageal Langerhans cells. Gastroenterology 100, 560-563.
58. Asahina, A., Hosoi, J., Grabbe, S., Granstein, R. D. (1995) Modulation of Langerhans cell function by epidermal nerves. J. Allergy Clin. Immunol. 96, 1178-1182.
59. Hosoi, J., Murphy, G. F., Egan, C. L., Lerner, E. A., Grabbe, S., Asahina, A., Granstein, R. D. (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 363, 159-163. (Pubitemid 23147013)
60. Kleyn, C. E., Schneider, L., Saraceno, R., Mantovani, C., Richards, H. L., Fortune, D. G., Cumberbatch, M., Dearman, R. J., Terenghi, G., Kimber, I., Griffiths, C. E. (2008) The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides. J. Invest. Dermatol. 128, 1273-1279.
61. Beresford, L., Orange, O., Bell, E. B., Miyan, J. A. (2004) Nerve fibers are required to evoke a contact sensitivity response in mice. Immunology 111, 118-125. (Pubitemid 38091056)
62. Saade, N. E., Massaad, C. A., Ochoa-Chaar, C. I., Jabbur, S. J., Safieh- Garabedian, B., Atweh, S. F. (2002) Upregulation of proinflammatory cytokines and nerve growth factor by intraplantar injection of capsaicin in rats. J. Physiol. 545, 241-253.
63. Jarvikallio, A., Harvima, I. T., Naukkarinen, A. (2003) Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema. Arch. Dermatol. Res. 295, 2-7.
64. Foreman, J. C. (1987) Substance P and calcitonin gene-related peptide: effects on mast cells and in human skin. Int. Arch. Allergy Appl. Immunol. 82, 366-371.
65. Cao, J., Papadopoulou, N., Kempuraj, D., Boucher, W. S., Sugimoto, K., Cetrulo, C. L., Theoharides, T. C. (2005) Human mast cells express corticotropin- releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J. Immunol. 174, 7665-7675. (Pubitemid 40806271)
66. Suto, H., Matsuda, H., Mitsuishi, K., Hira, K., Uchida, T., Unno, T., Ogawa, H., Ra, C. (1999) NC/Nga mice: a mouse model for atopic dermatitis. Int. Arch. Allergy Immunol. 120 (Suppl. 1), 70-75.
67. Amano, H., Negishi, I., Akiyama, H., Ishikawa, O. (2008) Psychological stress can trigger atopic dermatitis in NC/Nga mice: an inhibitory effect of corticotropin-releasing factor. Neuropsychopharmacology 33, 566-573.
68. Pavlovic, S., Daniltchenko, M., Tobin, D. J., Hagen, E., Hunt, S. P., Klapp, B. F., Arck, P. C., Peters, E. M. (2008) Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J. Invest. Dermatol. 128, 434-446.
69. Peters, E. M., Kuhlmei, A., Tobin, D. J., Muller-Rover, S., Klapp, B. F., Arck, P. C. (2005) Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin. Brain Behav. Immun. 19, 252-262.
70. Herz, U., Bunikowski, R., Renz, H. (1998) Role of T cells in atopic dermatitis. New aspects on the dynamics of cytokine production and the contribution of bacterial superantigens. Int. Arch. Allergy Immunol. 115, 179-190.
71. Kim, J. E., Cho, D. H., Kim, H. S., Kim, H. J., Lee, J. Y., Cho, B. K., Park, H. J. (2007) Expression of the corticotropin-releasing hormoneproopiomelanocortin axis in the various clinical types of psoriasis. Exp. Dermatol. 16, 104-109.
72. Yang, E. V., Kim, S. J., Donovan, E. L., Chen, M., Gross, A. C., Webster Marketon, J. I., Barsky, S. H., Glaser, R. (2009) Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav. Immun. 23, 267-275.
73. Scarparo, A. C., Sumida, D. H., Patrao, M. T., Avellar, M. C., Visconti, M. A., Maria de Lauro Castrucci, A. (2004) Catecholamine effects on human melanoma cells evoked by α1-adrenoceptors. Arch. Dermatol. Res. 296, 112-119.
74. Zheng, P. Y., Feng, B. S., Oluwole, C., Struiksma, S., Chen, X., Li, P., Tang, S. G., Yang, P. C. (2009) Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut 58, 1473-1479.
75. Teitelbaum, A. A., Gareau, M. G., Jury, J., Yang, P. C., Perdue, M. H. (2008) Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G452-G459.
76. Kokkotou, E., Torres, D., Moss, A. C., O'Brien, M., Grigoriadis, D. E., Karalis, K., Pothoulakis, C. (2006) Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. J. Immunol. 177, 3355-3361. (Pubitemid 44277855)
77. Tache, Y., Perdue, M. H. (2004) Role of peripheral CRF signaling pathways in stress-related alterations of gut motility and mucosal function. Neurogastroenterol. Motil. 16 (Suppl. 1), 137-142.
78. Meddings, J. B., Swain, M. G. (2000) Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology 119, 1019-1028.
79. Ohara, Y., McCarron, R. M., Hoffman, T. T., Sugano, H., Bembry, J., Lenz, F. A., Spatz, M. (2000) Adrenergic mediation of TNF α-stimulated ICAM-1 expression on human brain microvascular endothelial cells. Acta Neurochir. Suppl. 76, 117-120.
80. Ganz, T. (2003) Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720.
81. Gallo, R. L., Nizet, V. (2003) Endogenous production of antimicrobial peptides in innate immunity and human disease. Curr. Allergy Asthma Rep. 3, 402-409.
82. Nizet, V., Gallo, R. L. (2003) Cathelicidins and innate defense against invasive bacterial infection. Scand. J. Infect. Dis. 35, 670-676.
83. Henzler-Wildman, K. A., Martinez, G. V., Brown, M. F., Ramamoorthy, A. (2004) Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37. Biochemistry 43, 8459-8469.
84. Brogden, K. A. (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 3, 238-250.
85. Braff, M. H., Gallo, R. L. (2006) Antimicrobial peptides: an essential component of the skin defensive barrier. Curr. Top. Microbiol. Immunol. 306, 91-110.
86. Braff, M. H., Bardan, A., Nizet, V., Gallo, R. L. (2005) Cutaneous defense mechanisms by antimicrobial peptides. J. Invest. Dermatol. 125, 9-13.
87. Brogden, K. A., Ackermann, M., McCray Jr., P. B., Tack, B. F. (2003) Antimicrobial peptides in animals and their role in host defences. Int. J. Antimicrob. Agents 22, 465-478.
88. Lai, Y., Gallo, R. L. (2009) AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 30, 131-141.
89. Radek, K., Gallo, R. (2007) Antimicrobial peptides: natural effectors of the innate immune system. Semin. Immunopathol. 29, 27-43.
90. Glaser, R., Harder, J., Lange, H., Bartels, J., Christophers, E., Schroder, J. M. (2005) Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat. Immunol. 6, 57-64.
91. Kiehne, K., Fincke, A., Brunke, G., Lange, T., Folsch, U. R., Herzig, K. H. (2007) Antimicrobial peptides in chronic anal fistula epithelium. Scand. J. Gastroenterol. 42, 1063-1069.
92. Harder, J., Schroder, J. M. (2002) RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J. Biol. Chem. 277, 46779-46784.
93. Chen, X., Niyonsaba, F., Ushio, H., Okuda, D., Nagaoka, I., Ikeda, S., Okumura, K., Ogawa, H. (2005) Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J. Dermatol. Sci. 40, 123-132.
94. Agerberth, B., Grunewald, J., Castanos-Velez, E., Olsson, B., Jornvall, H., Wigzell, H., Eklund, A., Gudmundsson, G. H. (1999) Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. Am. J. Respir. Crit. Care Med. 160, 283-290.
95. Harder, J., Schroder, J. M. (2005) Antimicrobial peptides in human skin. Chem. Immunol. Allergy 86, 22-41.
96. Ouellette, A. J., Selsted, M. E. (1996) Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J. 10, 1280-1289.
97. Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., Gallo, R. L. (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414, 454-457.
98. Braff, M. H., Zaiou, M., Fierer, J., Nizet, V., Gallo, R. L. (2005) Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens. Infect. Immun. 73, 6771-6781.
99. Radek, K. A., Lopez-Garcia, B., Hupe, M., Niesman, I. R., Elias, P. M., Taupenot, L., Mahata, S. K., O'Connor, D. T., Gallo, R. L. (2008) The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J. Invest. Dermatol. 128, 1525-1534.
100. Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y., Bevins, C. L. (2003) Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422, 522-526. (Pubitemid 36433647)
101. Howell, M. D., Jones, J. F., Kisich, K. O., Streib, J. E., Gallo, R. L., Leung, D. Y. (2004) Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J. Immunol. 172, 1763-1767.
102. Moser, C., Weiner, D. J., Lysenko, E., Bals, R., Weiser, J. N., Wilson, J. M. (2002) β-Defensin 1 contributes to pulmonary innate immunity in mice. Infect. Immun. 70, 3068-3072.
103. Jiang, Y., Wang, Y., Kuang, Y., Wang, B., Li, W., Gong, T., Jiang, Z., Yang, D., Li, M. (2009) Expression of mouse β-defensin-3 in MDCK cells and its anti-influenza-virus activity. Arch. Virol. 154, 639-647.
104. Meyer, J. E., Harder, J., Gorogh, T., Weise, J. B., Schubert, S., Janssen, D., Maune, S. (2004) Human β-defensin-2 in oral cancer with opportunistic Candida infection. Anticancer Res. 24, 1025-1030. (Pubitemid 38625053)
105. Evans, S. E., Scott, B. L., Clement, C. G., Larson, D. T., Kontoyiannis, D., Lewis, R. E., Lasala, P. R., Pawlik, J., Peterson, J. W., Chopra, A. K., Klimpel, G., Bowden, G., Hook, M., Xu, Y., Tuvim, M. J., Dickey, B. F. (2010) Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am. J. Respir. Cell Mol. Biol. 42, 40-50.
106. Yamasaki, K., Schauber, J., Coda, A., Lin, H., Dorschner, R. A., Schechter, N. M., Bonnart, C., Descargues, P., Hovnanian, A., Gallo, R. L. (2006) Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J. 20, 2068-2080. (Pubitemid 44953906)
107. Ganz, T. (1994) Biosynthesis of defensins and other antimicrobial peptides. Ciba Found. Symp. 186, 62-71, discussion 71-76.
108. O'Connor, D. T. (1983) Chromogranin: widespread immunoreactivity in polypeptide hormone producing tissues and in serum. Regul. Pept. 6, 263-280.
109. Mahata, S. K. (1991) Effect of insulin on serotonin, 5- hydroxyindoleacetic acid, norepinephrine, epinephrine and corticosterone contents in chick. Neurosci. Lett. 121, 115-118.
110. Gayen, J. R., Saberi, M., Schenk, S., Biswas, N., Vaingankar, S. M., Cheung, W. W., Najjar, S. M., O'Connor, D. T., Bandyopadhyay, G., Mahata, S. K. (2009) A novel pathway of insulin sensitivity in chromogranin a null mice: a crucial role for pancreastatin in glucose homeostasis. J. Biol. Chem. 284, 28498-28509.
111. Metz-Boutigue, M. H., Kieffer, A. E., Goumon, Y., Aunis, D. (2003) Innate immunity: involvement of new neuropeptides. Trends Microbiol. 11, 585-592. (Pubitemid 37500910)
112. Cutuli, M., Cristiani, S., Lipton, J. M., Catania, A. (2000) Antimicrobial effects of α-MSH peptides. J. Leukoc. Biol. 67, 233-239.
113. Shimizu, M., Shigeri, Y., Tatsu, Y., Yoshikawa, S., Yumoto, N. (1998) Enhancement of antimicrobial activity of neuropeptide Y by N-terminal truncation. Antimicrob. Agents Chemother. 42, 2745-2746.
114. Fox, F. E., Kubin, M., Cassin, M., Niu, Z., Hosoi, J., Torii, H., Granstein, R. D., Trinchieri, G., Rook, A. H. (1997) Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: effects on B7, interleukin 10, and interleukin 12. J. Invest. Dermatol. 108, 43-48.
115. Mahata, S. K., O'Connor, D. T., Mahata, M., Yoo, S. H., Taupenot, L., Wu, H., Gill, B. M., Parmer, R. J. (1997) Novel autocrine feedback control of catecholamine release. A discrete chromogranin A fragment is a noncompetitive nicotinic cholinergic antagonist. J. Clin. Invest. 100, 1623-1633.
116. Mahata, S. K., Mahata, M., Yoo, S. H., Taupenot, L., Wu, H., Aroda, V. R., Livsey, C. V., Taulane, J. P., Goodman, M., Parmer, R. J., O'Connor, D. T. (1998) A novel, catecholamine release-inhibitory peptide from chromogranin A: autocrine control of nicotinic cholinergicstimulated exocytosis. Adv. Pharmacol. 42, 260-264.
117. Taupenot, L., Harper, K. L., O'Connor, D. T. (2003) The chromogranin- secretogranin family. N. Engl. J. Med. 348, 1134-1149.
118. Iimura, M., Gallo, R. L., Hase, K., Miyamoto, Y., Eckmann, L., Kagnoff, M. F. (2005) Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J. Immunol. 174, 4901-4907.
119. Chromek, M., Slamova, Z., Bergman, P., Kovacs, L., Podracka, L., Ehren, I., Hokfelt, T., Gudmundsson, G. H., Gallo, R. L., Agerberth, B., Brauner, A. (2006) The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med. 12, 636-641.
120. Schauber, J., Dorschner, R. A., Coda, A. B., Buchau, A. S., Liu, P. T., Kiken, D., Helfrich, Y. R., Kang, S., Elalieh, H. Z., Steinmeyer, A., Zugel, U., Bikle, D. D., Modlin, R. L., Gallo, R. L. (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J. Clin. Invest. 117, 803-811.
121. Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., Gallo, R. L. (2001) Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J. Invest. Dermatol. 117, 91-97.
122. Schauber, J., Oda, Y., Buchau, A. S., Yun, Q. C., Steinmeyer, A., Zugel, U., Bikle, D. D., Gallo, R. L. (2008) Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. J. Invest. Dermatol. 128, 816-824.
123. Aberg, K. M., Radek, K. A., Choi, E. H., Kim, D. K., Demerjian, M., Hupe, M., Kerbleski, J., Gallo, R. L., Ganz, T., Mauro, T., Feingold, K. R., Elias, P. M. (2007) Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J. Clin. Invest. 117, 3339-3349.
124. Wehkamp, J., Salzman, N. H., Porter, E., Nuding, S., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M., Linzmeier, R., Feathers, R. W., Chu, H., Lima Jr., H., Fellermann, K., Ganz, T., Stange, E. F., Bevins, C. L. (2005) Reduced Paneth cell α-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. USA 102, 18129-18134.
125. Fellermann, K., Stange, D. E., Schaeffeler, E., Schmalzl, H., Wehkamp, J., Bevins, C. L., Reinisch, W., Teml, A., Schwab, M., Lichter, P., Radlwimmer, B., Stange, E. F. (2006) A chromosome 8 gene-cluster polymorphism with low human β-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am. J. Hum. Genet. 79, 439-448.
126. Yano, H., Wershil, B. K., Arizono, N., Galli, S. J. (1989) Substance Pinduced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent. J. Clin. Invest. 84, 1276-1286.
127. Zhang, Y., Ramos, B. F., Jakschik, B. A. (1992) Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis. Science 258, 1957-1959. (Pubitemid 23026740)
128. Echtenacher, B., Mannel, D. N., Hultner, L. (1996) Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381, 75-77.
129. Raithel, M., Schneider, H. T., Hahn, E. G. (1999) Effect of substance P on histamine secretion from gut mucosa in inflammatory bowel disease. Scand. J. Gastroenterol. 34, 496-503.
130. Church, M. K., el-Lati, S., Caulfield, J. P. (1991) Neuropeptide-induced secretion from human skin mast cells. Int. Arch. Allergy Appl. Immunol. 94, 310-318.
131. Eutamene, H., Theodorou, V., Fioramonti, J., Bueno, L. (2003) Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats. J. Physiol. 553, 959-966.
132. Soderholm, J. D., Yang, P. C., Ceponis, P., Vohra, A., Riddell, R., Sherman, P. M., Perdue, M. H. (2002) Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Gastroenterology 123, 1099-1108.
133. Di Nardo, A., Vitiello, A., Gallo, R. L. (2003) Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide. J. Immunol. 170, 2274-2278. (Pubitemid 36245611)
134. Castagliuolo, I., Wershil, B. K., Karalis, K., Pasha, A., Nikulasson, S. T., Pothoulakis, C. (1998) Colonic mucin release in response to immobilization stress is mast cell dependent. Am. J. Physiol. 274, G1094-G1100.
135. Brown, D. H., Zwilling, B. S. (1994) Activation of the hypothalamic-pituitary- adrenal axis differentially affects the anti-mycobacterial activity of macrophages from BCG-resistant and susceptible mice. J. Neuroimmunol. 53, 181-187.
136. Zahwa, H., Yorty, J. L., Bonneau, R. H. (2008) Elevated maternal corticosterone during lactation hinders the neonatal adaptive immune response to herpes simplex virus (HSV) infection. Brain Behav. Immun. 22, 339-353.
137. Dalal, E., Medalia, O., Harari, O., Aronson, M. (1994) Moderate stress protects female mice against bacterial infection of the bladder by eliciting uroepithelial shedding. Infect. Immun. 62, 5505-5510.
138. Cao, J., Boucher, W., Kempuraj, D., Donelan, J. M., Theoharides, T. C. (2006) Acute stress and intravesical corticotropin-releasing hormone induces mast cell dependent vascular endothelial growth factor release from mouse bladder explants. J. Urol. 176, 1208-1213. (Pubitemid 44142585)
139. Quan, N., Avitsur, R., Stark, J. L., He, L., Shah, M., Caligiuri, M., Padgett, D. A., Marucha, P. T., Sheridan, J. F. (2001) Social stress increases the susceptibility to endotoxic shock. J. Neuroimmunol. 115, 36-45. (Pubitemid 32245651)
140. Reinheimer, T., Munch, M., Bittinger, F., Racke, K., Kirkpatrick, C. J., Wessler, I. (1998) Glucocorticoids mediate reduction of epithelial acetylcholine content in the airways of rats and humans. Eur. J. Pharmacol. 349, 277-284.
141. Valera, S., Ballivet, M., Bertrand, D. (1992) Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. USA 89, 9949-9953.
142. Elenkov, I. J., Webster, E. L., Torpy, D. J., Chrousos, G. P. (1999) Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: acute and chronic effects. Ann. N. Y. Acad. Sci. 876, 1-11, discussion 11-13.
143. Zhang, D., Shooshtarizadeh, P., Laventie, B. J., Colin, D. A., Chich, J. F., Vidic, J., de Barry, J., Chasserot-Golaz, S., Delalande, F., Van Dorsselaer, A., Schneider, F., Helle, K., Aunis, D., Prevost, G., Metz-Boutigue, M. H. (2009) Two chromogranin A-derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2. PLoS One 4, e4501.
144. Kluger, M. J. (1991) Fever: role of pyrogens and cryogens. Physiol. Rev. 71, 93-127.
145. Sundar, S. K., Becker, K. J., Cierpial, M. A., Carpenter, M. D., Rankin, L. A., Fleener, S. L., Ritchie, J. C., Simson, P. E., Weiss, J. M. (1989) Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses. Proc. Natl. Acad. Sci. USA 86, 6398-6402.
146. Weiss, J. M., Sundar, S. K., Cierpial, M. A., Ritchie, J. C. (1991) Effects of interleukin-1 infused into brain are antagonized by α-MSH in a dose-dependent manner. Eur. J. Pharmacol. 192, 177-179.
147. Schulte-Herbruggen, O., Quarcoo, D., Brzoska, T., Klehmet, J., Meisel, A., Meisel, C. (2008) α-MSH promotes spontaneous post-ischemic pneumonia in mice via melanocortin-receptor-1. Exp. Neurol. 210, 731-739.
148. Kiank, C., Daeschlein, G., Schuett, C. (2008) Pneumonia as a long-term consequence of chronic psychological stress in BALB/c mice. Brain Behav. Immun. 22, 1173-1177.
149. Baleeiro, C. E., Wilcoxen, S. E., Morris, S. B., Standiford, T. J., Paine III, R. (2003) Sublethal hyperoxia impairs pulmonary innate immunity. J. Immunol. 171, 955-963.
150. Bernhagen, J., Calandra, T., Mitchell, R. A., Martin, S. B., Tracey, K. J., Voelter, W., Manogue, K. R., Cerami, A., Bucala, R. (1993) MIF is a pituitary- derived cytokine that potentiates lethal endotoxaemia. Nature 365, 756-759.
151. Calandra, T., Froidevaux, C., Martin, C., Roger, T. (2003) Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis. J. Infect. Dis. 187 (Suppl. 2), S385-S390.
152. Bu, H. F., Wang, X., Zhu, Y. Q., Williams, R. Y., Hsueh, W., Zheng, X., Rozenfeld, R. A., Zuo, X. L., Tan, X. D. (2006) Lysozyme-modified probiotic components protect rats against polymicrobial sepsis: role of macrophages and cathelicidin-related innate immunity. J. Immunol. 177, 8767-8776.
153. Rivkin, I., Rosenblatt, J., Becker, E. L. (1975) The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin. J. Immunol. 115, 1126-1134.
154. Llewellyn-Jones, C. G., Stockley, R. A. (1994) The effects of β 2-agonists and methylxanthines on neutrophil function in vitro. Eur. Respir. J. 7, 1460-1466.
155. Silvestri, M., Oddera, S., Lantero, S., Rossi, G. A. (1999) β 2-Agonist-induced inhibition of neutrophil chemotaxis is not associated with modification of LFA-1 and Mac-1 expression or with impairment of polymorphonuclear leukocyte antibacterial activity. Respir. Med. 93, 416-423.
156. Matsunaga, K., Klein, T. W., Friedman, H., Yamamoto, Y. (2001) Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. J. Immunol. 167, 6518-6524. (Pubitemid 33081587)
157. Nizri, E., Irony-Tur-Sinai, M., Lory, O., Orr-Urtreger, A., Lavi, E., Brenner, T. (2009) Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J. Immunol. 183, 6681-6688.
158. Huston, J. M., Rosas-Ballina, M., Xue, X., Dowling, O., Ochani, K., Ochani, M., Yeboah, M. M., Chatterjee, P. K., Tracey, K. J., Metz, C. N. (2009) Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b. J. Immunol. 183, 552-559.
159. Weichhart, T., Haidinger, M., Horl, W. H., Saemann, M. D. (2008) Current concepts of molecular defense mechanisms operative during urinary tract infection. Eur. J. Clin. Invest. 38 (Suppl. 2), 29-38.
160. Prost, L. R., Sanowar, S., Miller, S. I. (2007) Salmonella sensing of antimicrobial mechanisms to promote survival within macrophages. Immunol. Rev. 219, 55-65.
161. Bottomley, M. J., Muraglia, E., Bazzo, R., Carfi, A. (2007) Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer. J. Biol. Chem. 282, 13592-13600.
162. Freestone, P. P., Sandrini, S. M., Haigh, R. D., Lyte, M. (2008) Microbial endocrinology: how stress influences susceptibility to infection. Trends Microbiol. 16, 55-64.
163. Alverdy, J., Holbrook, C., Rocha, F., Seiden, L., Wu, R. L., Musch, M., Chang, E., Ohman, D., Suh, S. (2000) Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann. Surg. 232, 480-489.
164. Winzer, K., Williams, P. (2001) Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria. Int. J. Med. Microbiol. 291, 131-143.
165. Bansal, T., Englert, D., Lee, J., Hegde, M., Wood, T. K., Jayaraman, A. (2007) Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression. Infect. Immun. 75, 4597-4607.
166. Freestone, P. P., Williams, P. H., Haigh, R. D., Maggs, A. F., Neal, C. P., Lyte, M. (2002) Growth stimulation of intestinal commensal Escherichia coli by catecholamines: a possible contributory factor in trauma-induced sepsis. Shock 18, 465-470.
167. Chen, C., Brown, D. R., Xie, Y., Green, B. T., Lyte, M. (2003) Catecholamines modulate Escherichia coli O157:H7 adherence to murine cecal mucosa. Shock 20, 183-188.
168. Methner, U., Rabsch, W., Reissbrodt, R., Williams, P. H. (2008) Effect of norepinephrine on colonization and systemic spread of Salmonella enterica in infected animals: role of catecholate siderophore precursors and degradation products. Int. J. Med. Microbiol. 298, 429-439.
169. Scheckelhoff, M. R., Telford, S. R., Wesley, M., Hu, L. T. (2007) Borrelia burgdorferi intercepts host hormonal signals to regulate expression of outer surface protein A. Proc. Natl. Acad. Sci. USA 104, 7247-7252.
170. Freestone, P. P., Haigh, R. D., Williams, P. H., Lyte, M. (2003) Involvement of enterobactin in norepinephrine-mediated iron supply from transferrin to enterohemorrhagic Escherichia coli. FEMS Microbiol. Lett. 222, 39-43.
171. Sandrini, S. M., Shergill, R., Woodward, J., Muralikuttan, R., Haigh, R. D., Lyte, M., Freestone, P. P. (2010) Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin. J. Bacteriol. 192, 587-594.
172. Clarke, S. R., Mohamed, R., Bian, L., Routh, A. F., Kokai-Kun, J. F., Mond, J. J., Tarkowski, A., Foster, S. J. (2007) The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin. Cell Host Microbe 1, 199-212. (Pubitemid 46706363)
173. Ganz, T. (2002) The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease. Isr. Med. Assoc. J. 4, 1043-1045.
174. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., Vaulont, S. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. USA 98, 8780-8785.
175. Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., Vaulont, S. (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. USA 99, 4596-4601.
176. Zhao, M., Chen, J., Wang, W., Wang, L., Ma, L., Shen, H., Li, M. (2008) Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats. Biochem. Biophys. Res. Commun. 373, 90-93.