Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer

Journal of Biological Chemistry

Volumn 282, Issue 18, 2007, Pages 13592-13600

  Bottomley, Matthew J ^a   Muraglia, Ester ^a   Bazzo, Renzo ^a   Carfì, Andrea ^a  

^a Istituto di Ricerche di Biologia Molecolare   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOINDUCERS; PSEUDOMONAS AERUGINOSA; QUORUM SENSING INHIBITORS;

BINDING SITES; CRYSTAL STRUCTURE; DIMERS; OPTIMIZATION; PATHOGENS;

BACTERIA;

BACTERIAL PROTEIN; LACTONE DERIVATIVE; LASR PROTEIN; PROTEIN SDIA; PROTEIN TRAR; REGULATOR PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; GAMMA BUTYROLACTONE; HOMOSERINE LACTONE; LACTONE; LASR PROTEIN, PSEUDOMONAS AERUGINOSA; SDIA PROTEIN, E COLI; TRANSACTIVATOR PROTEIN; TRAR PROTEIN, AGROBACTERIUM TUMEFACIENS; VIRULENCE FACTOR;

ARTICLE; BACTERIAL VIRULENCE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; LIGAND BINDING; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RHIZOBIUM RADIOBACTER; CHEMISTRY; COMPARATIVE STUDY; CYSTIC FIBROSIS; GRAM NEGATIVE INFECTION; HUMAN; METABOLISM; MORTALITY; OPPORTUNISTIC INFECTION; PATHOGENICITY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AGROBACTERIUM TUMEFACIENS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

4-BUTYROLACTONE; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYSTIC FIBROSIS; DNA-BINDING PROTEINS; ESCHERICHIA COLI PROTEINS; HUMANS; LACTONES; OPPORTUNISTIC INFECTIONS; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUORUM SENSING; STRUCTURAL HOMOLOGY, PROTEIN; TRANS-ACTIVATORS; VIRULENCE FACTORS;

EID: 34250357654     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700556200     Document Type: Article

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