Cutaneous defense mechanisms by antimicrobial peptides

Journal of Investigative Dermatology

Volumn 125, Issue 1, 2005, Pages 9-13

  Braff, Marissa H ^a   Bardan, Antoanella ^a   Nizet, Victor ^b   Gallo, Richard L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Atopic; Cathelicidins; Defensins; Dermatitis; Psoriasis; Staphylococcus; Streptococcus

Indexed keywords

ADRENOMEDULLIN; ALPHA DEFENSIN; ALPHA INTERMEDIN; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; BETA DEFENSIN; BETA THROMBOGLOBULIN; BRADYKININ; CATHELICIDIN; CHEMOKINE; CXCL9 CHEMOKINE; CYSTATIN C; EOSINOPHIL CATIONIC PROTEIN; FIBRINOPEPTIDE A; FIBRINOPEPTIDE B; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULYSIN; LACTOFERRICIN; LL 37 PEPTIDE; LYSOZYME; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTENSIN; PEPTIDE; PERFORIN; PSORIASIN; RANTES; RIBONUCLEASE; SUBSTANCE P; THROMBOCYTE FACTOR 4; THYMOSIN BETA4; UNCLASSIFIED DRUG;

ACNE VULGARIS; ANTIMICROBIAL ACTIVITY; CONTACT DERMATITIS; DERMATITIS; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFECTION RESISTANCE; LUPUS ERYTHEMATOSUS; PRIORITY JOURNAL; PSORIASIS; REVIEW; SKIN DISEASE; WOUND HEALING; WOUND INFECTION;

EID: 22144457975     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23587.x     Document Type: Article

References (58)

1. Allaker RP, Zihni C, Kapas S: An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora. FEMS Immunol Med Microbiol 23:289-293, 1999
2. Befus AD, Mowat C, Gilchrist M, Hu J, Solomon S, Bateman A: Neutrophil defensins induce histamine secretion from mast cells: Mechanisms of action. J Immunol 163:947-953, 1999
3. Blankenvoorde MF, van't Hof W, Walgreen-Weterings E, van Steenbergen TJ, Brand HS, Veerman EC, Nieuw Amerongen AV: Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis. Biol Chem 379:1371-1375, 1998
4. Caccavo D, Pellegrino NM, Altamura M, Rigon A, Amati L, Amoroso A, Jirillo E: Antimicrobial and immunoregulatory functions of lactoferrin and its potential therapeutic application. J Endotoxin Res 8:403-417, 2002
5. Chaly YV, Paleolog EM, Kolesnikova TS, Tikhonov II, Petratchenko EV, Voitenok NN: Neutrophil alpha-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur Cytokine Netw 11:257-266, 2000
6. Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM: Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol 167:623-627, 2001a
7. Cole AM, Shi J, Ceccarelli A, Kim YH, Park A, Ganz T: Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. Blood 97:297-304, 2001b
8. Conner K, Nern K, Rudisill J, O'Grady T, Gallo RL: The antimicrobial peptide LL-37 is expressed by keratinocytes in condyloma acuminatum and verruca vulgaris. J Am Acad Dermatol 47:347-350, 2002
9. Cumberbatch M, Dearman RJ, Uribe-Luna S, Headon DR, Ward PP, Conneely OM, Kimber I: Regulation of epidermal Langerhans cell migration by lactoferrin. Immunology 100:21-28, 2000
10. Cutuli M, Cristiani S, Lipton JM, Catania A: Antimicrobial effects of alpha-MSH peptides. J Leukoc Biol 67:233-239, 2000
11. Di Nardo A, Vitiello A, Gallo RL: Cutting edge: Mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide. J Immunol 170:2274-2278, 2003
12. Domachowske JB, Dyer KD, Adams AG, Leto TL, Rosenberg HF: Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. Nucleic Acids Res 26:3358-3363, 1998a
13. Domachowske JB, Dyer KD, Bonville CA, Rosenberg HF: Recombinant human eosinophil-derived neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus. J Infect Dis 177:1458-1464, 1998b
14. Dorschner RA, Lin KH, Murakami M, Gallo RL: Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: Innate immunity during development of the adaptive response. Pediatr Res 53:566-572, 2003
15. Dorschner RA, Lopez-Garcia B, Gallo RL: Skin microenvironment dictates susceptibility of bacteria to antimicrobial peptides. J Invest Dermatol 122: A133, 2004
16. Dorschner RA, Pestonjamasp VK, Tamakuwala S, et al: Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Invest Dermatol 117:91-97, 2001
17. Fang XM, Shu Q, Chen QX, Book M, Sahl HG, Hoeft A, Stuber F: Differential expression of alpha- and beta-defensins in human peripheral blood. Eur J Clin Invest 33:82-87, 2003
18. Frohm M, Agerberth B, Ahangari G, Stahle-Backdahl M, Liden S, Wigzell H, Gudmundsson GH: The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272:15258-15263, 1997
19. Gallo RL, Ono M, Povsic T, Page C, Eriksson E, Klagsbrun M, Bernfield M: Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 91:11035-11039, 1994
20. Glaser R, Harder J, Bartels J, Christophers E, Schroder J-M: Psoriasin (S100a7) is a major and potent E. coli-selective antimicrobial protein of healthy human skin. J Invest Dermatol 117:768, 2001
21. Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK: The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 10:1033-1043, 2002
22. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM: Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-560, 1997
23. Harder J, Bartels J, Christophers E, Schroder JM: Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707-5713, 2001
24. Harder J, Schroder JM: RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 277:46779-46784, 2002
25. Harwig SS, Ganz T, Lehrer RI: Neutrophil defensins: Purification, characterization, and antimicrobial testing. Methods Enzymol 236:160-172, 1994
26. Heilborn JD, Nilsson MF, Kratz G, Weber G, Sorensen O, Borregaard N, Stahle-Backdahl M: The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium. J Invest Dermatol 120:379-389, 2003
27. Kashima M: H1 histones contribute to candidacidal activities of human epidermal extract. J Dermatol 18:695-706, 1991
28. Kieffer AE, Goumon Y, Ruh O, et al: The N- and C-terminal fragments of ubiquitin are important for the antimicrobial activities. Faseb J 17:776-778, 2003
29. Koczulla R, von Degenfeld G, Kupatt C, et al: An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 111:1665-1672, 2003
30. Kowalska K, Carr DB, Lipkowski AW: Direct antimicrobial properties of substance P. Life Sci 71:747-750, 2002
31. Lambert RW, Campton K, Ding W, Ozawa H, Granstein RD: Langerhans cell expression of neuropeptide Y and peptide YY. Neuropeptides 36:246-251, 2002
32. Liu L, Roberts AA, Ganz T: By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J Immunol 170:575-580, 2003
33. Marchini G, Lindow S, Brismar H, et al: The newborn infant is protected by an innate antimicrobial barrier: Peptide antibiotics are present in the skin and vernix caseosa. Br J Dermatol 147:1127-1134, 2002
34. Meyer-Hoffert U, Wichmann N, Schwichtenberg L, White PC, Wiedow O: Suprnatants of Pseudomonas aeruginosa induce the Pseudomonas-specific antibiotic elafin in human keratinocytes. Exp Dermatol 12:418-425, 2003
35. Murakami M, Lopez-Garcia B, Braff M, Dorschner RA, Gallo RL: Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense. J Immunol 172:3070-3077, 2004
36. Nizet V, Ohtake T, Lauth X, et al: Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457, 2001
37. Nomura I, Gao B, Boguniewicz M, Darst MA, Travers JB, Leung DY: Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J Allergy Clin Immunol 112: 1195-1202, 2003
38. Ong PY, Ohtake T, Brandt C, et al: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-1160, 2002
39. Oono T, Huh WK, Shirafuji Y, Akiyama H, Iwatsuki K: Localization of human beta-defensin-2 and human neutrophil peptides in superficial folliculitis. Br J Dermatol 148:188-191, 2003
40. Ortega MR, Ganz T, Milner SM: Human beta defensin is absent in burn blister fluid. Burns 26:724-726, 2000
41. Parish CA, Jiang H, Tokiwa Y, et al: Broad-spectrum antimicrobial activity of hemoglobin. Bioorg Med Chem 9:377-382, 2001
42. Philpott MP: Defensins and acne. Mol Immunol 40:457-462, 2003
43. Rosen H, Michel BR: Redundant contribution of myeloperoxidase-dependent systems to neutrophil-mediated killing of Escherichia coli. Infect Immun 65:4173-4178, 1997
44. Schittek B, Hipfel R, Sauer B, et al: Dermcidin: A novel human antibiotic peptide secreted by sweat glands. Nat Immunol 2:1133-1137, 2001
45. Schutte BC, Mitros JP, Bartlett JA, et al: Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 99:2129-2133, 2002
46. Simpson AJ, Maxwell AI, Govan JR, Haslett C, Sallenave JM: Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens. FEBS Lett 452:309-313, 1999
47. Sohnle PG, Hunter MJ, Hahn B, Chazin WJ: Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14). J Infect Dis 182:1272-1275, 2000
48. Sorensen OE, Cowland JB, Theilgaard-Monch K, Liu L, Ganz T, Borregaard N: Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol 170:5583-5589, 2003
49. Sorensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS, Borregaard N: Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97:3951-3959, 2001
50. Stenger S, Hanson DA, Teitelbaum R, et al: An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282:121-125, 1998
51. Takahashi M, Horiuchi Y, Tezuka T: Presence of bactericidal/permeability- increasing protein in human and rat skin. Exp Dermatol 13:55-60, 2004
52. Takahashi M, Tezuka T, Katunuma N: Inhibition of growth and cysteine proteinase activity of Staphylococcus aureus V8 by phosphorylated cystatin alpha in skin cornified envelope. FEBS Lett 355:275-278, 1994
53. Tang YQ, Yeaman MR, Selsted ME: Antimicrobial peptides from human platelets. Infect Immun 70:6524-6533, 2002
54. Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M: Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides. Blood 100:553-559, 2002
55. Wingens M, van Bergen BH, Hiemstra PS, et al: Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J Invest Dermatol 111:996-1002, 1998
56. Yang D, Chertov O, Bykovskaia SN, et al: Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286: 525-528, 1999
57. Yang N, Strom MB, Mekonnen SM, Svendsen JS, Rekdal O: The effects of shortening lactoferrin derived peptides against tumour cells, bacteria and normal human cells. J Pept Sci 10:37-46, 2004
58. Zaiou M, Nizet V, Gallo RL: Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol 120:810-816, 2003