Synthesis of a novel GC-specific covalent-binding DNA affinity-cleavage agent based on pyrrolobenzodiazepines (PBDs)

Chemical Communications

Volumn , Issue 4, 1996, Pages 563-565

  Thurston, David E ^a   Morris, Steven J ^a   Hartley, John A ^b  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; EDETIC ACID;

ARTICLE; CONJUGATE; COVALENT BOND; DNA CLEAVAGE; DRUG BINDING; DRUG SYNTHESIS; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE;

EID: 0029912567     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/cc9960000563     Document Type: Article

References (20)

1. For example see: S. Neidle, M. S. Puvvada and D. E. Thurston, Eur. J. Cancer, 1994, 30A, 567; J. A. Hartley and R. L. Souhami, 'DNA Sequence Specificity of Anticancer Agents', in Cancer Chemotherapy; Frontiers in Pharmacology and Therapeutics Series, ed J. A. Hickman and T. Tritton, Blackwell Scientific Ltd, 1993, pp. 251-280; Y. Hashimoto, J. Pharm. Soc. Jpn, 1994, 114, 357.
2. For example see: S. Neidle, M. S. Puvvada and D. E. Thurston, Eur. J. Cancer, 1994, 30A, 567; J. A. Hartley and R. L. Souhami, 'DNA Sequence Specificity of Anticancer Agents', in Cancer Chemotherapy; Frontiers in Pharmacology and Therapeutics Series, ed J. A. Hickman and T. Tritton, Blackwell Scientific Ltd, 1993, pp. 251-280; Y. Hashimoto, J. Pharm. Soc. Jpn, 1994, 114, 357.
3. For example see: S. Neidle, M. S. Puvvada and D. E. Thurston, Eur. J. Cancer, 1994, 30A, 567; J. A. Hartley and R. L. Souhami, 'DNA Sequence Specificity of Anticancer Agents', in Cancer Chemotherapy; Frontiers in Pharmacology and Therapeutics Series, ed J. A. Hickman and T. Tritton, Blackwell Scientific Ltd, 1993, pp. 251-280; Y. Hashimoto, J. Pharm. Soc. Jpn, 1994, 114, 357.
4. For example see: (a) J. P. Sluka, J. H. Griffin, D. P. Mack and P. B. Dervan, J. Am. Chem. Soc., 1990, 112, 6369;
5. (b) G. Mehta, T. Sambaiah, B. G. Maiya, M. Sirish and D. Chatterjee, J. Chem. Soc., Perkin Trans. 1, 1993, 22, 2667;
6. (c) P. E. Nielson, M. Egholm and O. Buchardt, Bioconjugate Chemistry, 1994, 5, 1043;
7. (d) Y. W. Ebright, Y. Chen, P. S. Pendergrast and R. H. Ebright, Biochemistry, 1992, 31, 10664.
8. M. D. Lee, G. A. Ellestrad and D. B. Borders, Acc. Chem. Res., 1991, 24, 235.
9. L. L. Guan, J. Kuwahara and Y. Sugiura, Biochemistry, 1993, 32, 6141.
10. D. S. Bose, G. B. Jones and D. E. Thurston, Tetrahedron, 1992, 48, 751.
11. D. E. Thurston, 'Advances in the Study of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumour Antibiotics', in 'Molecular Aspects of Anticancer Drug-DNA Interactions', Vol. 1, Topics in Molecular and Structural Biology, ed. S. Neidle and M. J. Waring, Macmillan Press, 1993, pp. 54-88.
12. G. B. Jones, PhD Thesis, 1991, University of Portsmouth, UK.
13. D. E. Thurston and D. S. Bose, Chem. Rev., 1994, 94, 433.
14. D. R. Langley and D. E. Thurston, J. Org. Chem., 1987, 52, 91.
15. S. J. Morris, PhD Thesis, 1992, University of Portsmouth, UK.
16. P. H. Johnson and L. I. Grossman, Biochemistry, 1977, 16, 4217.
17. R. P. Hertzberg, S. M. Hecht, V. L. Reynolds, I. J. Molineux and L. H. Hurley, Biochemistry, 1986, 25, 1249; L. H. Hurley, T. Reck, D. E. Thurston, D. R. Langley, K. G. Holden, R. P. Hertzberg, J. R. E. Hoover, G. Gallagher, L. F. Faucette Jnr, S.-M. Mong and R. K. Johnson, Chem. Res. Toxicol., 1988, 1, 258.
18. R. P. Hertzberg, S. M. Hecht, V. L. Reynolds, I. J. Molineux and L. H. Hurley, Biochemistry, 1986, 25, 1249; L. H. Hurley, T. Reck, D. E. Thurston, D. R. Langley, K. G. Holden, R. P. Hertzberg, J. R. E. Hoover, G. Gallagher, L. F. Faucette Jnr, S.-M. Mong and R. K. Johnson, Chem. Res. Toxicol., 1988, 1, 258.
19. D. S. Bose, A. S. Thompson, J. Ching, J. A. Hartley, M. D. Berardini, T. C. Jenkins, S. Neidle, L. H. Hurley and D. E. Thurston, J. Am. Chem. Soc., 1992, 114, 4939; D. S. Bose, A. S. Thompson, M. Smellie, M. D. Berardini, J. A. Hartley, T. C. Jenkins, S. Neidle and D. E. Thurston, J. Chem. Soc., Chem. Commun., 1992, 1518.
20. D. S. Bose, A. S. Thompson, J. Ching, J. A. Hartley, M. D. Berardini, T. C. Jenkins, S. Neidle, L. H. Hurley and D. E. Thurston, J. Am. Chem. Soc., 1992, 114, 4939; D. S. Bose, A. S. Thompson, M. Smellie, M. D. Berardini, J. A. Hartley, T. C. Jenkins, S. Neidle and D. E. Thurston, J. Chem. Soc., Chem. Commun., 1992, 1518.