Analysis of dominant enhancers and suppressors of activated Notch in Drosophila

Genetics

Volumn 144, Issue 3, 1996, Pages 1127-1141

  Verheyen, Esther M ^a   Purcell, Karen J ^a   Fortini, Mark E ^a   Artavanis Tsakonas, Spyros ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DROSOPHILA; ENHANCER REGION; GENE ACTIVATION; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); EYE; FEMALE; GENES, SUPPRESSOR; GENETIC COMPLEMENTATION TEST; MALE; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0029985177     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (80)

1. AHMED, I., P. ZAGOURAS and S. ARTAVANIS-TSAKONAS, 1995 Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells. Mech. Dev. 53: 73-85.
2. ARTAVANIS-TSAKONAS, S., K. MATSUNO and M. E. FORTINI, 1995 Notch signaling. Science 268: 225-232.
3. ASTER, J., W. PEAR, R. HASSF.RJIAN, H. ERBA, F. DAM et al, 1994 Functional analysis of the TAX-1 gene, a human homolog of Drosophila Notch. Cold Spring Harbor Symp. Quant. Biol. 59: 125-136.
4. AXEI.ROD, J. D., K. MATSUNO, S. ARTAVANIS-TSAKONAS and N. PERRIMON, 1996 Interaction between wingless and Notch signaling pathways mediated by disheveled. Science 271: 1826-1832.
5. BAILEY, A. M., and J. W. POSAKONY, 1995 Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9: 2609-2622.
6. B.VKER, N. E., and A. E. ZITRON, 1995 Drosophila eye development: Notch and Delta amplify a ncurogenic pattern conferred on the morphogenetic furrow by scabrous. Mech. Dev. 49: 173-189.
7. BAKER, N. E., M. MLODZIK and G. M. RUBIN, 1990 Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science 250: 1370-1377.
8. B.ANG, A. G., andj. W. POSAKONY, 1992 The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensor)' organ development. Genes Dev. 6: 1752-1769.
9. BETTLER, D., S. PEARSON and B. YEDYOBNICK, 1996 The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics 143: 859-875.
10. BRAND, M., andj.A. CAMPOS-ORTEGA, 1990 Second-site modifiers of the split mutation of Notch define genes involved in neurogenesis in Umsophila melanogasler. Roux's Arch. Dev. Biol. 198: 275-285.
11. BREEDEN, ,L., and K. NASMYTH, 1987 Similarity between cell cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila. Nature 329: 651-654.
12. BROU, G., F. LOGEAT, M. LECOURTOIS.J. VANDEKERCKHOE-E, P. KOURH-SKY et al., 1994 Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and its human homolog, KBF2/ RBPJk, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8: 2491-2503.
13. BUSSEAU, I., R. J. DlEDF.RICH, T. XU and S. ARTAVANIS-TSAKONAS, 1994 A member of the Notch group of interacting loci, deltex, encodes a cytoplasmic basic protein. Genetics 136: 585-596.
14. GAGAN, R. L., and D. F. READY, 1989 Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 3: 1099-1112.
15. COFFMAX, C., P. SKOGI.UND, W. IlARRisand C. KINTNER, 1993 Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73: 659-671.
16. DE LA CONCHA, A., U. DIETRICH, D. WEIGEL andj. A. GUIPOS-ORTEGA, 1988 Functional interactions of neurogenic genes of Drosophila melanogaster. Genetics 118: 499-508.
17. DEUDAKIS, C., A. PREISS, D. A. HARTLEY- and S. ARTAVANIS-TSAKONAS, 1991 Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics 129: 803-823.
18. DIETRICH, U., andJ.A. GUIPOS-ORTECA, 1984 The expression of neurogenic loci in imaginai epidermal cells of Drosophila melanogasler.]. Neurogenet. 1: 315-332.
19. DORSKY, R. I., D. H. RAPAPORT and W. A. HARRIS, 1995 Xotch inhibits cell differentiation in the Xenopus retina. Neuron 14: 487-496.
20. EDGAR, B. A., and P. H. O'FARREU, 1989 Genetic control of cell division patterns in the Drosophila embryo. Cell 57: 177-187.
21. ELLISEN, L. W., J. BIRD, D. C. WEST, A. L. SORENG, T. C. REYNOLDS et al., 1991 Tan-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-661.
22. FEI ION, R. G., P. KOOH, I. REBAY, C. REGAN, T. Xu et al, 1990 Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61: 523-534.
23. FEHON, R. G., K. JOHANSEN, I. REBAY and S. ARTAVANIS-TSAKONAS, 1991 Complex spatial and temporal regulation of Notch expression during embryonic and imaginai development of Drosophila: implications for Notch function. J. Cell. Biol. 113: 657-669.
24. FISCHER-VIZE, J. A., P. D. VIZE and G. M. RUBIN, 1992 A unique mutation in the Enhancer of split gene complex affects the fates of the mystery cells in the developing Drosophila eye. Development 115:89-101.
25. FLEMING, R.J., T. N. SCOTTGALE, R.J. DIEDERICH and S. ARTAVANISTSAKONAS, 1990 The gene Sen-ate encodes a putative EGF-Iike transmembrane protein essential for proper ectodermal development. Genes Dev. 4: 2188-2201.
26. FI.YBASE, 1994 The Drosophila genetic database. Nucleic Acids Res. 22: 3456-3458 (http://morgan.harvard.edu/).
27. FORTINI, M., and S. ARTAVANIS-TSAKONAS, 1994 Genetic and molecular interactions between Notch and Suppressor of Hairless in Drosophila. Cell 79: 273-282.
28. FORTINT, M., I. REBAY, L. CARON and S. ARTAVANIS-TSAKONAS, 1993 An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365: 555-557.
29. FOSTER, G. G., 1975 Negative complementation at the Notch locus of Drosophila melanogaster. Genetics 81: 99-120.
30. FURUKAWA, T., S. MARUYAMA, M. KAWAICHI and T. HONJO, 1992 The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Cell 69: 1191-1197.
31. GINIGER, E., K. TIETJE, L. Y. JAN and Y. N. JAN, 1994 lola encodes a putative transcription factor required for axon growth and guidance in Drosophila. Development 120: 1385-1398.
32. GORMAN, M.J., and J. R. GIRTON, 1992 A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 131:99-112.
33. HEBERI.EIN, U., I. K. HARHIARAN and G. M. RUBIN, 1993 Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Rasl. Dev. Biol. 160: 51-63.
34. HEITZI.ER, P., and P. SIMPSON, 1991 The choice of cell fate in the epidermis of Drosophila. Cell 64: 1083-1092.
35. HEITZI.ER, P., M. BOUROIS, L. RUEL, C. GVRTERET and P. SIMPSON, 1996 Genes of the Enhancer of split and achoete-scnte complexes are required for the regulator)' loop between Notch and Delta during lateral signaling in Drosophila. Development 122: 161-171.
36. HING, H. K., X. SUN and S. ARTAVANIS-TSAKONAS, 1994 Modulation of wingless signaling by Notch in Drosophila. Mech. Dev. 47: 261-268.
37. JENNINGS, B., A. PREISS, C. DEUDAKIS and S. BRAY, 1994 The Notch signaling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 120: 3537-3548.
38. KARIM, F. D., H. C. CHANO, M. THERRIEN, D. A. WASSARMAN, T. LAVERTY et al, 1996 A screen for genes that function downstream of RasI during Drosophila eye development. Genetics 143: 315-329.
39. KENNISON, J. A., andj. W. TAMKUN, 1988 Dosage-dependent modifiers of Polycomband Antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. USA 85: 8136-8140.
40. KIDD, S., M. R. KELLEY and M.W. YOUNG, 1986 Sequence of the Notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol. Cell. Biol. 6: 3094-3108.
41. KIDD, S., M. K. BAYLIES, G. P. GASIG and M. W. YOUNG, 1989 Structure and distribution of the Notch protein in developing Drosophila. Genes Dev. 3: 1113-1129.
42. KOLODKIN, A., A. PICKUP, D. LIN, C. GOODNAN and U. BANERJEE, 1994 Characterization of Star and its interactions with seven/ess and EGF receptor during photoreceptor development in Drosophila. Development 120: 1731-1745.
43. KOPAN, R., J. S. NYE and H. WEINTRAUB, 1994 The intracellular domain of mouse Notch: a constitutive)1 activated represser of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120: 2385-2396.
44. KOPCZYNSKI, C. C., A. K. ALTON, K. FECHTEI., P.J. KOOH and M. A. T. MUSK/WITCH, 1988 Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factors of vertebrates. Genes Dev. 2: 1723-1735.
45. LECOURTOIS, M., and F. ScirVEiSGurn, 1995 The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split Complex genes triggered by Notch signaling. Genes Dev. 9: 2598-2608.
46. LEWS, E. B., and F. BACHER, 1968 Method of feeding ethyl methanesulfonate (EMS) to Drosophila males. Drosophila Information Service 43: 193-194.
47. LIEBER, T., S. KIDD, E. ALCAMO, V. CORBIN and M. W. YOUNG, 1993 Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7: 1949-1965.
48. LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, San Diego.
49. MATSUNO, K., R.J. DIEDERICH, M.J. Go, C. M. BLAUMUEI.I.ER and S. ARTAVANIS-TSAKONAS, 1995 deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121: 2633-2644.
50. MLODZIK, M., N. E. BAKER and G. M. RUBIN, 1990 Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes Dev. 4: 1848-1861.
51. NvF.J. S., R. KOPAN and R. AXEL, 1994 An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 120: 2421-2430.
52. PARKS, A. L., F. R. TURNER and M. A. T. MUSKAVTTCH, 1995 Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development. Mech. Dev. 50: 201-216.
53. PATTERTON, D., and A. P. WOI.FFE, 1996 Developmental roles for chromatin and chromosomal structure. Dev. Biol. 173: 2-13.
54. PEAR, W. S., J. C. ASTER, M. L. SCOTT, R. P. HASSERJIAN, B. SOFFER et al, 1996 Exclusive development of T-ccll neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183: 2283-2291.
55. PORTIN, P., 1975 Allelic negative complementation at the Abruplex locus of Drosophila melanogaster. Genetics 81: 121-133.
56. PRICE, J.V., R.J. CLIFFORD and T. SCHüPBACH, 1989 The maternal ventralizing locus loipedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56: 1085-1092.
57. REBAV, L, R.J. FLEMING, R. G. FEHON, L. CHERRAS, P. CHEKBAS et al., 1991 Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67: 687-699.
58. REBAY, I., R. FEHON and S. ARTAVANTS-TSAKONAS, 1993 Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74: 318-329.
59. ROBBINS, J., B. BLONDEL, D. GALIAILVN and R. CALLAHAN, 1992 Mouse mammary tumor gene int-3: a member of the Kotch gene family transforms epithelial cells. J. Virol. 66: 2594-2599.
60. ROGGE, R. D., C. A. KARLOVICH and U. BAXERJEE, 1991 Genetic dissection of a neurodevelopmental pathway: son ofsevenless functions donnstream of the sevenless and EGF receptor tyrosine kinases. Cell 64: 39-48.
61. ROCGE, R., P. J. GREEN, J. URAXO, S. HORN-SABAN, M. MI.ODZIK et al., 1995 The role of yan in mediating the choice between cell division and differentiation. Development 121: 3947-3958.
62. SCHOI.Z, H.,J. DEATRICK, A. KIAES and C. KLAEMBT, 1993 Genetic dissection of pointed, a Drosophila gene encoding two ETS-related proteins. Genetics 135: 455-468.
63. ScinvEisGUTH, F., 1995 Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal noturn. Development 121: 1875-1884.
64. ScinvElsGUTH, F., and J.W. POSAKOXV, 1992 Suppressor of Hairless, the Drosophila homolog of the mouse recombination signalbinding protein gene, controls sense organ cell fates. Cell 69: 1199-1212.
65. SEEGER, M., G. TEAR, D. FERRES-.MIARCO and C. S. GOODNAN, 1993 Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10: 409-426.
66. SMOLLER, D., C. FRIEDEI., A. SCHMID, D. BETTLER, L. LAM et al., 1990 The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Genes Dev. 4: 1688-1700.
67. STIFANT, S., C. M. BLAUMUEU.ER, N.J. REDHEAD, R. E. HILL and S. ARTAVANTS-TSAKOXAS, 1992 Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins. Nature Genet. 2: 119-127.
68. STRUHL, G., K. FITZGERALD and I. GREEXWALD, 1993 Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74: 331-345.
69. SUN, X., and S. ARTAVAXIS-TSAKOXAS, 1996 The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development 122: 2465-2474.
70. TEARLE, R., A. TOMI.INSON and R. SAINT, 1994 The dominant Drop eye mutations of Drosophila melanogaslerdedne two loci implicated in normal eye development. Mol. Gen. Genet. 244: 426-434.
71. TOMI.IXSOX, A., and D. READY, 1987 Cell fate in the Drosophila ommatidium. Dev. Biol. 123: 2G4-275.
72. VASSIX, H., J. VIELMETTER and J. A. CAMPOS-ORTEGA, 1985 Genetic interactions in early neurogenesis of Drosophila melanogasler. J. Neurogenet. 2: 291-308.
73. VASSIX, H., K. A. BREMER, E. Kxusr andj. A. CAMPOS-ORTEGA, 1987 The neurogenic gene Delta of Drosophila melanogasterh expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBOJ. 6: 3431-3440.
74. WEI.SHOXS, W. J., 1971 Genetic basis for two types of recessive lethality at the Notch locus of Drosophila. Genetics 68: 259-268.
75. WILKINSOX, H. A., K. FITZGERALD and I. GREEXWAI.D, 1994 Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 79: 1187-1198.
76. WHARTON', K. A., K. M.JOHAXSEN, T. Xu and S. ARTAVAXIS-TSAKOXAS, 1985 Nucleotide sequence from the neurogenic locus A'o/r/i implies a gene product that shares homolog)- with proteins containing EGF-like repeats. Cell 43: 567-581.
77. Xu, T., and S. ARTAVAXIS-TS.VKOXAS, 1990 deltex, a locus interacting with the neurogenic genes, Notch, Deltaand mastennind'm Drosophila metanogaster. Genetics 126: 665-677.
78. Xu, T., I. REBAY, R.J. FLEMING, T. N. SCOTTGAI.E and S. ARTAVANTSTSAKOXAS, 1990 The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev. 4: 464-475.
79. YOCHEM, J., K. WESTOX and I. GREEMVALD, 1988 The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature 335: 547-550.
80. ZAGOURAS, P., S. STIFANT, C. M. BIAUMUELLER, M. L. CARCAXGIU and S. ARTAVAXIS-TSAKOXAS, 1995 Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc. Natl. Acad. Sci. USA 92: 6414-6418.