Mechanisms of ligand-mediated inhibition in notch signaling activity in Drosophila

Developmental Dynamics

Volumn 239, Issue 3, 2010, Pages 798-805

  Fiuza, Ulla Maj ^a   Klein, Thomas ^b   Arias, Alfonso Martinez ^a   Hayward, Penelope ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Delta; Inhibition; Notch; Serrate; Signaling

Indexed keywords

LIGAND; NOTCH RECEPTOR;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DROSOPHILA; ENDOCYTOSIS; EVOLUTION; INHIBITION KINETICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELL CULTURE TECHNIQUES; COCULTURE TECHNIQUES; CROSSES, GENETIC; DROSOPHILA MELANOGASTER; ENDOCYTOSIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; LIGANDS; RECEPTORS, NOTCH; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 77149178693     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22207     Document Type: Article

References (34)

1. Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A. 2000. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 5:207-216.
2. de Celis JF, Bray S. 1997. Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124:3241-3251.
3. de Celis JF, Bray SJ. 2000. The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe. Development 127:1291-1302.
4. de Celis JF, Garcia-Bellido A. 1994. Modifications of the notch function by Abruptex mutations in Drosophila melanogaster. Genetics 136:183-194.
5. Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B. et al. 2008. A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol 15:849-857.
6. Doherty D, Feger G, Younger-Shepherd S, Jan LY, Jan YN. 1996. Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev 10:421-434.
7. Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S. 1990. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61:523-534.
8. Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S. 1991. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol 113:657-669.
9. Furriols M, Bray S. 2001. A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr Biol 11:60-64.
10. Glittenberg M, Pitsouli C, Garvey C, Delidakis C, Bray S. 2006. Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J 25:4697-4706.
11. Hayward P, Brennan K, Sanders P,Balayo T, DasGupta R, Perrimon N, Martinez Arias A. 2005. Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development 132:1819-1830.
12. Heitzler P, Simpson P. 1993. Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development 117:1113-1123.
13. Irvine KD, Rauskolb C. 2001. Boundaries in development: formation and function. Annu Rev Cell Dev Biol 17:189-214.
14. Itoh M, Kim CH, Palardy G, Oda T, Jiang YJ, Maust D, Yeo SY, Lorick K, Wright GJ, Ariza-McNaughton L. 2003. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell 4:67-82.
15. Jacobsen TL, Brennan K, Arias AM, Muskavitch MA. 1998. Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. Development 125:4531-4540.
16. Klein T, Brennan K, Martinez Arias A. 1997. An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila. Dev Biol 189:123-134.
17. Kopan R, Schroeter EH, Weintraub H, Nye JS. 1996. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A 93:1683-1688.
18. Kovall RA. 2007. Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex. Curr Opin Struct Biol 17:117-127.
19. Krejci A, Bray S. 2007. Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev 21:1322-1327.
20. Lawrence N, Klein T, Brennan K, Martinez Arias A. 2000. Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila. Development 127:3185-3195.
21. Le Borgne R, Schweisguth F. 2003. Notch signaling: endocytosis makes delta signal better. Curr Biol 13:R273-R275.
22. Le Borgne R, Remaud S, Hamel S, Schweisguth F. 2005. Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol 3:e96.
23. Lieber T, Kidd S, Young MW. 2002. kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev 16:209-221.
24. Micchelli CA, Rulifson EJ, Blair SS. 1997. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124:1485-1495.
25. Nichols JT, Miyamoto A, Olsen SL, D'Souza B, Yao C, Weinmaster G. 2007. DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol 176:445-458.
26. Parks AL, Klueg KM, Stout JR, Muskavitch MA. 2000. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 127:1373-1385.
27. Parks AL, Stout JR, Shepard SB, Klueg KM, Dos Santos AA, Parody TR, Vaskova M, Muskavitch MA. 2006. Structure-function analysis of Delta trafficking, receptor binding, and signaling in Drosophila. Genetics 174:1947-1961.
28. Pavlopoulos E, Pitsouli C,Klueg KM, Muskavitch MA, Moschonas NK, Delidakis C. 2001. Neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev Cell 1:807-816.
29. Perez L, Milan M, Bray S, Cohen SM. 2005. Ligand-binding and signaling properties of the Ax[M1] form of Notch. Mech Dev 122:479-486.
30. Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC. 2000. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol 20:1825-1835.
31. Sanchez-Irizarry C, Carpenter AC,Weng AP, Pear WS, Aster JC, Blacklow SC. 2004. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol 24:9265-9273.
32. Schroeter EH, Kisslinger JA, Kopan R. 1998. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-386.
33. Schweisguth F. 2004. Notch signaling activity. Curr Biol 14:R129-R138.
34. Speicher SA, Thomas U, Hinz U, Knust E. 1994. The Serrate locus of Drosophila and its role inmorphogenesis of the wing imaginal discs: control of cell proliferation. Development 120:535-544.