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Volumn 225, Issue 1-2, 2010, Pages 43-51

Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity

Author keywords

Dopaminergic neurons; GDNF; Microglia; Nitric oxide; Parkinson's disease; PI3K

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 77955662358     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.04.010     Document Type: Article
Times cited : (32)

References (109)
  • 1
    • 0034526219 scopus 로고    scopus 로고
    • Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system
    • Aoi M., Date I., Tomita S., Ohmoto T. Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. Neurol. Res. 2000, 22:832-836.
    • (2000) Neurol. Res. , vol.22 , pp. 832-836
    • Aoi, M.1    Date, I.2    Tomita, S.3    Ohmoto, T.4
  • 2
    • 0037330339 scopus 로고    scopus 로고
    • Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration
    • Arimoto T., Bing G. Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiol. Dis. 2003, 12:35-45.
    • (2003) Neurobiol. Dis. , vol.12 , pp. 35-45
    • Arimoto, T.1    Bing, G.2
  • 3
    • 0035178264 scopus 로고    scopus 로고
    • Role of nitric oxide in a progressive neurodegeneration model of Parkinson's disease in the rat
    • Barthwal M.K., Srivastava N., Dikshit M. Role of nitric oxide in a progressive neurodegeneration model of Parkinson's disease in the rat. Redox Rep. 2001, 6:297-302.
    • (2001) Redox Rep. , vol.6 , pp. 297-302
    • Barthwal, M.K.1    Srivastava, N.2    Dikshit, M.3
  • 4
    • 0031711224 scopus 로고    scopus 로고
    • Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis
    • Beal M.F. Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Ann. Neurol. 1998, 44:S110-S114.
    • (1998) Ann. Neurol. , vol.44
    • Beal, M.F.1
  • 5
    • 0033571375 scopus 로고    scopus 로고
    • Anatomical and functional reconstruction of the nigrostriatal system in vitro: selective innervation of the striatum by dopaminergic neurons
    • Becq H., Bosler O., Geffard M., Enjalbert A., Herman J.P. Anatomical and functional reconstruction of the nigrostriatal system in vitro: selective innervation of the striatum by dopaminergic neurons. J. Neurosci. Res. 1999, 58:553-566.
    • (1999) J. Neurosci. Res. , vol.58 , pp. 553-566
    • Becq, H.1    Bosler, O.2    Geffard, M.3    Enjalbert, A.4    Herman, J.P.5
  • 6
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    • Brunet A., Datta S.R., Greenberg M.E. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 2001, 11:297-305.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 7
    • 35848952507 scopus 로고    scopus 로고
    • PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity
    • Carrasco E., Casper D., Werner P. PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. J. Neurosci. Res. 2007, 85:3109-3117.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 3109-3117
    • Carrasco, E.1    Casper, D.2    Werner, P.3
  • 8
    • 0032563356 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice
    • Cheng F.C., Ni D.R., Wu M.C., Kuo J.S., Chia L.G. Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. Neurosci. Lett. 1998, 252:87-90.
    • (1998) Neurosci. Lett. , vol.252 , pp. 87-90
    • Cheng, F.C.1    Ni, D.R.2    Wu, M.C.3    Kuo, J.S.4    Chia, L.G.5
  • 12
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • Cunningham C., Wilcockson D.C., Campion S., Lunnon K., Perry V.H. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 2005, 25:9275-9284.
    • (2005) J. Neurosci. , vol.25 , pp. 9275-9284
    • Cunningham, C.1    Wilcockson, D.C.2    Campion, S.3    Lunnon, K.4    Perry, V.H.5
  • 13
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease
    • Damier P., Hirsch E.C., Agid Y., Graybiel A.M. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 1999, 122(Pt 8):1437-1448.
    • (1999) Brain , vol.122 , Issue.PART 8 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 14
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 15
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T., Lindenau J., Haid S., Dichgans J., Schulz J.B. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J. Neurochem. 2000, 74:2213-2216.
    • (2000) J. Neurochem. , vol.74 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 17
    • 2042425526 scopus 로고    scopus 로고
    • Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor
    • Ding Y.M., Jaumotte J.D., Signore A.P., Zigmond M.J. Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor. J. Neurochem. 2004, 89:776-787.
    • (2004) J. Neurochem. , vol.89 , pp. 776-787
    • Ding, Y.M.1    Jaumotte, J.D.2    Signore, A.P.3    Zigmond, M.J.4
  • 18
    • 47749144016 scopus 로고    scopus 로고
    • Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo
    • Du Y., Li X., Yang D., Zhang X., Chen S., Huang K., Le W. Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. Exp. Biol. Med. (Maywood) 2008, 233:881-890.
    • (2008) Exp. Biol. Med. (Maywood) , vol.233 , pp. 881-890
    • Du, Y.1    Li, X.2    Yang, D.3    Zhang, X.4    Chen, S.5    Huang, K.6    Le, W.7
  • 19
    • 18044380103 scopus 로고    scopus 로고
    • Oxidative stress, induced by 6-hydroxydopamine, reduces proteasome activities in PC12 cells: implications for the pathogenesis of Parkinson's disease
    • Elkon H., Melamed E., Offen D. Oxidative stress, induced by 6-hydroxydopamine, reduces proteasome activities in PC12 cells: implications for the pathogenesis of Parkinson's disease. J. Mol. Neurosci. 2004, 24:387-400.
    • (2004) J. Mol. Neurosci. , vol.24 , pp. 387-400
    • Elkon, H.1    Melamed, E.2    Offen, D.3
  • 20
    • 0345257314 scopus 로고    scopus 로고
    • Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
    • Eslamboli A., Cummings R.M., Ridley R.M., Baker H.F., Muzyczka N., Burger C., Mandel R.J., Kirik D., Annett L.E. Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus). Exp. Neurol. 2003, 184:536-548.
    • (2003) Exp. Neurol. , vol.184 , pp. 536-548
    • Eslamboli, A.1    Cummings, R.M.2    Ridley, R.M.3    Baker, H.F.4    Muzyczka, N.5    Burger, C.6    Mandel, R.J.7    Kirik, D.8    Annett, L.E.9
  • 21
    • 34347391508 scopus 로고    scopus 로고
    • Microglia repetitively isolated from in vitro mixed glial cultures retain their initial phenotype
    • Floden A.M., Combs C.K. Microglia repetitively isolated from in vitro mixed glial cultures retain their initial phenotype. J. Neurosci. Meth. 2007, 164:218-224.
    • (2007) J. Neurosci. Meth. , vol.164 , pp. 218-224
    • Floden, A.M.1    Combs, C.K.2
  • 23
    • 0037375843 scopus 로고    scopus 로고
    • Dopaminergic neurons develop axonal projections to their target areas in organotypic co-cultures of the ventral mesencephalon and the striatum/prefrontal cortex
    • Franke H., Schelhorn N., Illes P. Dopaminergic neurons develop axonal projections to their target areas in organotypic co-cultures of the ventral mesencephalon and the striatum/prefrontal cortex. Neurochem. Int. 2003, 42:431-439.
    • (2003) Neurochem. Int. , vol.42 , pp. 431-439
    • Franke, H.1    Schelhorn, N.2    Illes, P.3
  • 24
    • 34248657576 scopus 로고    scopus 로고
    • Signalling molecules essential for neuronal survival and differentiation
    • Frebel K., Wiese S. Signalling molecules essential for neuronal survival and differentiation. Biochem. Soc. Trans. 2006, 34:1287-1290.
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 1287-1290
    • Frebel, K.1    Wiese, S.2
  • 25
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao H.M., Hong J.S., Zhang W., Liu B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 2002, 22:782-790.
    • (2002) J. Neurosci. , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 26
    • 0036316772 scopus 로고    scopus 로고
    • Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
    • Gao H.M., Jiang J., Wilson B., Zhang W., Hong J.S., Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J. Neurochem. 2002, 81:1285-1297.
    • (2002) J. Neurochem. , vol.81 , pp. 1285-1297
    • Gao, H.M.1    Jiang, J.2    Wilson, B.3    Zhang, W.4    Hong, J.S.5    Liu, B.6
  • 28
    • 0037203948 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide
    • Gayle D.A., Ling Z., Tong C., Landers T., Lipton J.W., Carvey P.M. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res. Dev. Brain Res. 2002, 133:27-35.
    • (2002) Brain Res. Dev. Brain Res. , vol.133 , pp. 27-35
    • Gayle, D.A.1    Ling, Z.2    Tong, C.3    Landers, T.4    Lipton, J.W.5    Carvey, P.M.6
  • 29
    • 2942586899 scopus 로고    scopus 로고
    • GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases
    • Ghribi O., Herman M.M., Pramoonjago P., Spaulding N.K., Savory J. GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases. Neurobiol. Dis. 2004, 16:417-427.
    • (2004) Neurobiol. Dis. , vol.16 , pp. 417-427
    • Ghribi, O.1    Herman, M.M.2    Pramoonjago, P.3    Spaulding, N.K.4    Savory, J.5
  • 31
    • 0032472794 scopus 로고    scopus 로고
    • Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system
    • Glazner G.W., Mu X., Springer J.E. Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system. J. Comp. Neurol. 1998, 391:42-49.
    • (1998) J. Comp. Neurol. , vol.391 , pp. 42-49
    • Glazner, G.W.1    Mu, X.2    Springer, J.E.3
  • 32
    • 0037052631 scopus 로고    scopus 로고
    • Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin
    • Gramsbergen J.B., Sandberg M., Moller Dall A., Kornblit B., Zimmer J. Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. Brain Res. 2002, 935:47-58.
    • (2002) Brain Res. , vol.935 , pp. 47-58
    • Gramsbergen, J.B.1    Sandberg, M.2    Moller Dall, A.3    Kornblit, B.4    Zimmer, J.5
  • 34
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • Griffin R.J., Moloney A., Kelliher M., Johnston J.A., Ravid R., Dockery P., O'Connor R., O'Neill C. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 2005, 93:105-117.
    • (2005) J. Neurochem. , vol.93 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6    O'Connor, R.7    O'Neill, C.8
  • 36
    • 13844292495 scopus 로고    scopus 로고
    • Inflammation-induced GDNF improves locomotor function after spinal cord injury
    • Hashimoto M., Nitta A., Fukumitsu H., Nomoto H., Shen L., Furukawa S. Inflammation-induced GDNF improves locomotor function after spinal cord injury. NeuroReport 2005, 16:99-102.
    • (2005) NeuroReport , vol.16 , pp. 99-102
    • Hashimoto, M.1    Nitta, A.2    Fukumitsu, H.3    Nomoto, H.4    Shen, L.5    Furukawa, S.6
  • 37
    • 12144269020 scopus 로고    scopus 로고
    • Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons
    • Herrera A.J., Tomas-Camardiel M., Venero J.L., Cano J., Machado A. Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. J. Neural. Transm. 2005, 112:111-119.
    • (2005) J. Neural. Transm. , vol.112 , pp. 111-119
    • Herrera, A.J.1    Tomas-Camardiel, M.2    Venero, J.L.3    Cano, J.4    Machado, A.5
  • 38
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?
    • Hirsch E.C., Hunot S., Damier P., Faucheux B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?. Ann. Neurol. 1998, 44:S115-S120.
    • (1998) Ann. Neurol. , vol.44
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 39
    • 0032733076 scopus 로고    scopus 로고
    • Rat primary cultured microglia express glial cell line-derived neurotrophic factor receptors
    • Honda S., Nakajima K., Nakamura Y., Imai Y., Kohsaka S. Rat primary cultured microglia express glial cell line-derived neurotrophic factor receptors. Neurosci. Lett. 1999, 275:203-206.
    • (1999) Neurosci. Lett. , vol.275 , pp. 203-206
    • Honda, S.1    Nakajima, K.2    Nakamura, Y.3    Imai, Y.4    Kohsaka, S.5
  • 40
    • 29744466028 scopus 로고    scopus 로고
    • Role of inflammation in the pathogenesis of Parkinson's disease: models, mechanisms, and therapeutic interventions
    • Hong J.S. Role of inflammation in the pathogenesis of Parkinson's disease: models, mechanisms, and therapeutic interventions. Ann. N. Y. Acad. Sci. 2005, 1053:151-152.
    • (2005) Ann. N. Y. Acad. Sci. , vol.1053 , pp. 151-152
    • Hong, J.S.1
  • 41
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 1999, 162:3749-3752.
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 45
  • 46
    • 0036499736 scopus 로고    scopus 로고
    • Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration
    • Iravani M.M., Kashefi K., Mander P., Rose S., Jenner P. Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience 2002, 110:49-58.
    • (2002) Neuroscience , vol.110 , pp. 49-58
    • Iravani, M.M.1    Kashefi, K.2    Mander, P.3    Rose, S.4    Jenner, P.5
  • 47
    • 35748940962 scopus 로고    scopus 로고
    • Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia
    • Jana M., Jana A., Liu X., Ghosh S., Pahan K. Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia. J. Immunol. 2007, 179:4142-4152.
    • (2007) J. Immunol. , vol.179 , pp. 4142-4152
    • Jana, M.1    Jana, A.2    Liu, X.3    Ghosh, S.4    Pahan, K.5
  • 48
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • discussion S36-28.
    • Jenner, P., 2003. Oxidative stress in Parkinson's disease. Ann Neurol 53 Suppl 3, S26-36; discussion S36-28.
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Jenner, P.1
  • 49
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner P., Olanow C.W. Understanding cell death in Parkinson's disease. Ann. Neurol. 1998, 44:S72-S84.
    • (1998) Ann. Neurol. , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 50
    • 62549143065 scopus 로고    scopus 로고
    • Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40+ microglia by comparison to CD40- microglia
    • Kawahara K., Yoshida A., Koga K., Yokoo S., Kuniyasu A., Gotoh T., Sawada M., Nakayama H. Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40+ microglia by comparison to CD40- microglia. J. Neuroimmunol. 2009, 208:70-79.
    • (2009) J. Neuroimmunol. , vol.208 , pp. 70-79
    • Kawahara, K.1    Yoshida, A.2    Koga, K.3    Yokoo, S.4    Kuniyasu, A.5    Gotoh, T.6    Sawada, M.7    Nakayama, H.8
  • 51
    • 0034663061 scopus 로고    scopus 로고
    • Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia
    • Kim W.G., Mohney R.P., Wilson B., Jeohn G.H., Liu B., Hong J.S. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 2000, 20:6309-6316.
    • (2000) J. Neurosci. , vol.20 , pp. 6309-6316
    • Kim, W.G.1    Mohney, R.P.2    Wilson, B.3    Jeohn, G.H.4    Liu, B.5    Hong, J.S.6
  • 52
    • 0035900197 scopus 로고    scopus 로고
    • Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium
    • King T.D., Bijur G.N., Jope R.S. Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain Res. 2001, 919:106-114.
    • (2001) Brain Res. , vol.919 , pp. 106-114
    • King, T.D.1    Bijur, G.N.2    Jope, R.S.3
  • 53
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2
    • Knott C., Stern G., Wilkin G.P. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol. Cell. Neurosci. 2000, 16:724-739.
    • (2000) Mol. Cell. Neurosci. , vol.16 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 56
    • 13244275007 scopus 로고    scopus 로고
    • Neuroprotective effect of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins
    • Kotake Y., Taguchi R., Okuda K., Sekiya Y., Tasaki Y., Hirobe M., Ohta S. Neuroprotective effect of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins. Brain Res. 2005, 1033:143-150.
    • (2005) Brain Res. , vol.1033 , pp. 143-150
    • Kotake, Y.1    Taguchi, R.2    Okuda, K.3    Sekiya, Y.4    Tasaki, Y.5    Hirobe, M.6    Ohta, S.7
  • 57
    • 27744434081 scopus 로고    scopus 로고
    • Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures
    • Kress G.J., Reynolds I.J. Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures. Neurobiol. Dis. 2005, 20:639-645.
    • (2005) Neurobiol. Dis. , vol.20 , pp. 639-645
    • Kress, G.J.1    Reynolds, I.J.2
  • 58
    • 0030950227 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery
    • Lapchak P.A., Miller P.J., Collins F., Jiao S. Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery. Neuroscience 1997, 78:61-72.
    • (1997) Neuroscience , vol.78 , pp. 61-72
    • Lapchak, P.A.1    Miller, P.J.2    Collins, F.3    Jiao, S.4
  • 59
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • Lawson L.J., Perry V.H., Dri P., Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990, 39:151-170.
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 60
    • 0035503074 scopus 로고    scopus 로고
    • Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease
    • Le W., Rowe D., Xie W., Ortiz I., He Y., Appel S.H. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci 2001, 21:8447-8455.
    • (2001) J Neurosci , vol.21 , pp. 8447-8455
    • Le, W.1    Rowe, D.2    Xie, W.3    Ortiz, I.4    He, Y.5    Appel, S.H.6
  • 63
    • 1242272720 scopus 로고    scopus 로고
    • Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation
    • Li F.Q., Lu X.Z., Liang X.B., Zhou H.F., Xue B., Liu X.Y., Niu D.B., Han J.S., Wang X.M. Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation. J. Neuroimmunol. 2004, 148:24-31.
    • (2004) J. Neuroimmunol. , vol.148 , pp. 24-31
    • Li, F.Q.1    Lu, X.Z.2    Liang, X.B.3    Zhou, H.F.4    Xue, B.5    Liu, X.Y.6    Niu, D.B.7    Han, J.S.8    Wang, X.M.9
  • 64
    • 20044389086 scopus 로고    scopus 로고
    • Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons
    • Li F.Q., Wang T., Pei Z., Liu B., Hong J.S. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. J. Neural. Transm. 2005, 112:331-347.
    • (2005) J. Neural. Transm. , vol.112 , pp. 331-347
    • Li, F.Q.1    Wang, T.2    Pei, Z.3    Liu, B.4    Hong, J.S.5
  • 65
    • 16344374513 scopus 로고    scopus 로고
    • Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage
    • Li G., Cui G., Tzeng N.S., Wei S.J., Wang T., Block M.L., Hong J.S. Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. FASEB J. 2005, 19:489-496.
    • (2005) FASEB J. , vol.19 , pp. 489-496
    • Li, G.1    Cui, G.2    Tzeng, N.S.3    Wei, S.J.4    Wang, T.5    Block, M.L.6    Hong, J.S.7
  • 67
    • 0027285510 scopus 로고
    • GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L.F., Doherty D.H., Lile J.D., Bektesh S., Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993, 260:1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 68
    • 37549058856 scopus 로고    scopus 로고
    • Encapsulated cell biodelivery of GDNF: a novel clinical strategy for neuroprotection and neuroregeneration in Parkinson's disease?
    • Lindvall O., Wahlberg L.U. Encapsulated cell biodelivery of GDNF: a novel clinical strategy for neuroprotection and neuroregeneration in Parkinson's disease?. Exp. Neurol. 2008, 209:82-88.
    • (2008) Exp. Neurol. , vol.209 , pp. 82-88
    • Lindvall, O.1    Wahlberg, L.U.2
  • 69
    • 0035084329 scopus 로고    scopus 로고
    • Molecular consequences of activated microglia in the brain: overactivation induces apoptosis
    • Liu B., Wang K., Gao H.M., Mandavilli B., Wang J.Y., Hong J.S. Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J. Neurochem. 2001, 77:182-189.
    • (2001) J. Neurochem. , vol.77 , pp. 182-189
    • Liu, B.1    Wang, K.2    Gao, H.M.3    Mandavilli, B.4    Wang, J.Y.5    Hong, J.S.6
  • 70
    • 0037381043 scopus 로고    scopus 로고
    • Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation
    • Liu Y., Qin L., Li G., Zhang W., An L., Liu B., Hong J.S. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J. Pharmacol. Exp. Ther. 2003, 305:212-218.
    • (2003) J. Pharmacol. Exp. Ther. , vol.305 , pp. 212-218
    • Liu, Y.1    Qin, L.2    Li, G.3    Zhang, W.4    An, L.5    Liu, B.6    Hong, J.S.7
  • 71
    • 58149395816 scopus 로고    scopus 로고
    • RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation
    • Malagelada C., Jin Z.H., Greene L.A. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J. Neurosci. 2008, 28:14363-14371.
    • (2008) J. Neurosci. , vol.28 , pp. 14363-14371
    • Malagelada, C.1    Jin, Z.H.2    Greene, L.A.3
  • 72
    • 0036751973 scopus 로고    scopus 로고
    • Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys
    • Maswood N., Grondin R., Zhang Z., Stanford J.A., Surgener S.P., Gash D.M., Gerhardt G.A. Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys. Neurobiol. Aging 2002, 23:881-889.
    • (2002) Neurobiol. Aging , vol.23 , pp. 881-889
    • Maswood, N.1    Grondin, R.2    Zhang, Z.3    Stanford, J.A.4    Surgener, S.P.5    Gash, D.M.6    Gerhardt, G.A.7
  • 73
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • McGeer P.L., Itagaki S., Akiyama H., McGeer E.G. Rate of cell death in parkinsonism indicates active neuropathological process. Ann. Neurol. 1988, 24:574-576.
    • (1988) Ann. Neurol. , vol.24 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    McGeer, E.G.4
  • 75
    • 39049179635 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines
    • Nagatsu T., Sawada M. Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cell. Mol. Neurobiol. 2006, 26:781-802.
    • (2006) Cell. Mol. Neurobiol. , vol.26 , pp. 781-802
    • Nagatsu, T.1    Sawada, M.2
  • 76
    • 0030992419 scopus 로고    scopus 로고
    • Electrophysiological studies of rat substantia nigra neurons in an in vitro slice preparation after middle cerebral artery occlusion
    • Nakanishi H., Tamura A., Kawai K., Yamamoto K. Electrophysiological studies of rat substantia nigra neurons in an in vitro slice preparation after middle cerebral artery occlusion. Neuroscience 1997, 77:1021-1028.
    • (1997) Neuroscience , vol.77 , pp. 1021-1028
    • Nakanishi, H.1    Tamura, A.2    Kawai, K.3    Yamamoto, K.4
  • 77
    • 0031948066 scopus 로고    scopus 로고
    • Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta
    • Nguyen V.T., Walker W.S., Benveniste E.N. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta. Eur. J. Immunol. 1998, 28:2537-2548.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2537-2548
    • Nguyen, V.T.1    Walker, W.S.2    Benveniste, E.N.3
  • 80
    • 13144282676 scopus 로고    scopus 로고
    • Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study
    • Patel N.K., Bunnage M., Plaha P., Svendsen C.N., Heywood P., Gill S.S. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann. Neurol. 2005, 57:298-302.
    • (2005) Ann. Neurol. , vol.57 , pp. 298-302
    • Patel, N.K.1    Bunnage, M.2    Plaha, P.3    Svendsen, C.N.4    Heywood, P.5    Gill, S.S.6
  • 82
    • 27644530602 scopus 로고    scopus 로고
    • LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia
    • Qin H., Wilson C.A., Lee S.J., Zhao X., Benveniste E.N. LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Blood 2005, 106:3114-3122.
    • (2005) Blood , vol.106 , pp. 3114-3122
    • Qin, H.1    Wilson, C.A.2    Lee, S.J.3    Zhao, X.4    Benveniste, E.N.5
  • 83
    • 0035081125 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor (GDNF) prevents neurodegeneration in models of Parkinson's disease
    • Reilly C.E. Glial cell line-derived neurotrophic factor (GDNF) prevents neurodegeneration in models of Parkinson's disease. J. Neurol. 2001, 248:76-78.
    • (2001) J. Neurol. , vol.248 , pp. 76-78
    • Reilly, C.E.1
  • 84
    • 0030884756 scopus 로고    scopus 로고
    • Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease
    • Rosenblad C., Martinez-Serrano A., Bjorklund A. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience 1998, 82:129-137.
    • (1998) Neuroscience , vol.82 , pp. 129-137
    • Rosenblad, C.1    Martinez-Serrano, A.2    Bjorklund, A.3
  • 85
    • 0032939002 scopus 로고    scopus 로고
    • Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle
    • Rosenblad C., Kirik D., Devaux B., Moffat B., Phillips H.S., Bjorklund A. Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle. Eur. J. NeuroSci. 1999, 11:1554-1566.
    • (1999) Eur. J. NeuroSci. , vol.11 , pp. 1554-1566
    • Rosenblad, C.1    Kirik, D.2    Devaux, B.3    Moffat, B.4    Phillips, H.S.5    Bjorklund, A.6
  • 86
    • 33747186125 scopus 로고    scopus 로고
    • Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk
    • Saavedra A., Baltazar G., Santos P., Carvalho C.M., Duarte E.P. Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk. Neurobiol. Dis. 2006, 23:533-542.
    • (2006) Neurobiol. Dis. , vol.23 , pp. 533-542
    • Saavedra, A.1    Baltazar, G.2    Santos, P.3    Carvalho, C.M.4    Duarte, E.P.5
  • 87
    • 0035841910 scopus 로고    scopus 로고
    • GFRalpha-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area
    • Sarabi A., Hoffer B.J., Olson L., Morales M. GFRalpha-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area. J. Comp. Neurol. 2001, 441:106-117.
    • (2001) J. Comp. Neurol. , vol.441 , pp. 106-117
    • Sarabi, A.1    Hoffer, B.J.2    Olson, L.3    Morales, M.4
  • 88
    • 0033962594 scopus 로고    scopus 로고
    • Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons
    • Sawada H., Ibi M., Kihara T., Urushitani M., Nakanishi M., Akaike A., Shimohama S. Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. J. Neurochem. 2000, 74:1175-1184.
    • (2000) J. Neurochem. , vol.74 , pp. 1175-1184
    • Sawada, H.1    Ibi, M.2    Kihara, T.3    Urushitani, M.4    Nakanishi, M.5    Akaike, A.6    Shimohama, S.7
  • 89
    • 0028796770 scopus 로고
    • Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice
    • Schulz J.B., Matthews R.T., Muqit M.M., Browne S.E., Beal M.F. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J. Neurochem. 1995, 64:936-939.
    • (1995) J. Neurochem. , vol.64 , pp. 936-939
    • Schulz, J.B.1    Matthews, R.T.2    Muqit, M.M.3    Browne, S.E.4    Beal, M.F.5
  • 91
    • 0041430632 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin
    • Shibata H., Katsuki H., Nishiwaki M., Kume T., Kaneko S., Akaike A. Lipopolysaccharide-induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin. J. Neurochem. 2003, 86:1201-1212.
    • (2003) J. Neurochem. , vol.86 , pp. 1201-1212
    • Shibata, H.1    Katsuki, H.2    Nishiwaki, M.3    Kume, T.4    Kaneko, S.5    Akaike, A.6
  • 92
    • 0035134830 scopus 로고    scopus 로고
    • Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease
    • Teismann P., Ferger B. Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease. Synapse 2001, 39:167-174.
    • (2001) Synapse , vol.39 , pp. 167-174
    • Teismann, P.1    Ferger, B.2
  • 94
    • 15544365143 scopus 로고    scopus 로고
    • Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    • Testa C.M., Sherer T.B., Greenamyre J.T. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res. Mol. Brain Res. 2005, 134:109-118.
    • (2005) Brain Res. Mol. Brain Res. , vol.134 , pp. 109-118
    • Testa, C.M.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 95
    • 70350347175 scopus 로고    scopus 로고
    • Akt signal transduction dysfunction in Parkinson's disease
    • Timmons S., Coakley M.F., Moloney A.M., C O.N. Akt signal transduction dysfunction in Parkinson's disease. Neurosci. Lett. 2009, 467:30-35.
    • (2009) Neurosci. Lett. , vol.467 , pp. 30-35
    • Timmons, S.1    Coakley, M.F.2    Moloney, A.M.3    C, O.N.4
  • 96
    • 0038054032 scopus 로고    scopus 로고
    • Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK
    • Ugarte S.D., Lin E., Klann E., Zigmond M.J., Perez R.G. Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK. J. Neurosci. Res. 2003, 73:105-112.
    • (2003) J. Neurosci. Res. , vol.73 , pp. 105-112
    • Ugarte, S.D.1    Lin, E.2    Klann, E.3    Zigmond, M.J.4    Perez, R.G.5
  • 97
    • 0031034813 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation
    • van Weering D.H., Bos J.L. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation. J. Biol. Chem. 1997, 272:249-254.
    • (1997) J. Biol. Chem. , vol.272 , pp. 249-254
    • van Weering, D.H.1    Bos, J.L.2
  • 98
    • 33645867671 scopus 로고    scopus 로고
    • Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease
    • Vijitruth R., Liu M., Choi D.Y., Nguyen X.V., Hunter R.L., Bing G. Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease. J. Neuroinflammation 2006, 3:6.
    • (2006) J. Neuroinflammation , vol.3 , pp. 6
    • Vijitruth, R.1    Liu, M.2    Choi, D.Y.3    Nguyen, X.V.4    Hunter, R.L.5    Bing, G.6
  • 99
    • 0036906534 scopus 로고    scopus 로고
    • Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation
    • Wang M.J., Lin W.W., Chen H.L., Chang Y.H., Ou H.C., Kuo J.S., Hong J.S., Jeng K.C. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur. J. NeuroSci. 2002, 16:2103-2112.
    • (2002) Eur. J. NeuroSci. , vol.16 , pp. 2103-2112
    • Wang, M.J.1    Lin, W.W.2    Chen, H.L.3    Chang, Y.H.4    Ou, H.C.5    Kuo, J.S.6    Hong, J.S.7    Jeng, K.C.8
  • 100
    • 1342316811 scopus 로고    scopus 로고
    • Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures
    • Wang T., Liu B., Qin L., Wilson B., Hong J.S. Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures. J. Neuroimmunol. 2004, 147:68-72.
    • (2004) J. Neuroimmunol. , vol.147 , pp. 68-72
    • Wang, T.1    Liu, B.2    Qin, L.3    Wilson, B.4    Hong, J.S.5
  • 101
    • 0027194462 scopus 로고
    • New stereological methods for counting neurons
    • West M.J. New stereological methods for counting neurons. Neurobiol. Aging 1993, 14:275-285.
    • (1993) Neurobiol. Aging , vol.14 , pp. 275-285
    • West, M.J.1
  • 102
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease
    • Wu D.C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D.K., Ischiropoulos H., Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 2002, 22:1763-1771.
    • (2002) J. Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 103
    • 36749097843 scopus 로고    scopus 로고
    • Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity
    • Xing B., Liu M., Bing G. Neuroprotection with pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF-kappaB and JNK activation and suppression of COX-2 activity. J. Neuroimmunol. 2007, 192:89-98.
    • (2007) J. Neuroimmunol. , vol.192 , pp. 89-98
    • Xing, B.1    Liu, M.2    Bing, G.3
  • 104
    • 41149177024 scopus 로고    scopus 로고
    • Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
    • Xing B., Xin T., Hunter R.L., Bing G. Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. J. Neuroinflammation 2008, 5:4.
    • (2008) J. Neuroinflammation , vol.5 , pp. 4
    • Xing, B.1    Xin, T.2    Hunter, R.L.3    Bing, G.4
  • 105
    • 13844280470 scopus 로고    scopus 로고
    • Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease
    • Yasuhara T., Shingo T., Muraoka K., Kobayashi K., Takeuchi A., Yano A., Wenji Y., Kameda M., Matsui T., Miyoshi Y., Date I. Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease. J. Neurosurg. 2005, 102:80-89.
    • (2005) J. Neurosurg. , vol.102 , pp. 80-89
    • Yasuhara, T.1    Shingo, T.2    Muraoka, K.3    Kobayashi, K.4    Takeuchi, A.5    Yano, A.6    Wenji, Y.7    Kameda, M.8    Matsui, T.9    Miyoshi, Y.10    Date, I.11
  • 108
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    • Zhang W., Wang T., Pei Z., Miller D.S., Wu X., Block M.L., Wilson B., Zhou Y., Hong J.S., Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005, 19:533-542.
    • (2005) FASEB J. , vol.19 , pp. 533-542
    • Zhang, W.1    Wang, T.2    Pei, Z.3    Miller, D.S.4    Wu, X.5    Block, M.L.6    Wilson, B.7    Zhou, Y.8    Hong, J.S.9    Zhang, J.10
  • 109
    • 14744284455 scopus 로고    scopus 로고
    • Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection
    • Zhou H.F., Liu X.Y., Niu D.B., Li F.Q., He Q.H., Wang X.M. Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection. Neurobiol. Dis. 2005, 18:441-449.
    • (2005) Neurobiol. Dis. , vol.18 , pp. 441-449
    • Zhou, H.F.1    Liu, X.Y.2    Niu, D.B.3    Li, F.Q.4    He, Q.H.5    Wang, X.M.6


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