메뉴 건너뛰기




Volumn 74, Issue 5, 2000, Pages 2213-2216

Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo

Author keywords

Free radicals; Inflammation; Microglia; MPTP; Nitric oxide synthase; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; DOPAMINE DERIVATIVE; FREE RADICAL; NITRIC OXIDE SYNTHASE;

EID: 0034006478     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742213.x     Document Type: Article
Times cited : (301)

References (24)
  • 1
    • 0031930771 scopus 로고    scopus 로고
    • Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease
    • Banati R. B., Daniel S. E., and Blunt S. B. (1998) Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Mov. Disord. 13, 221-227.
    • (1998) Mov. Disord. , vol.13 , pp. 221-227
    • Banati, R.B.1    Daniel, S.E.2    Blunt, S.B.3
  • 2
    • 0029125857 scopus 로고
    • Aging, energy and oxidative stress in neurodegenerative disease
    • Beal M. F. (1995) Aging, energy and oxidative stress in neurodegenerative disease. Ann. Neurol. 38, 357-366.
    • (1995) Ann. Neurol. , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 4
    • 0025941639 scopus 로고
    • Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase
    • Bredt D. S., Glatt C. E., Hwang P. M., Fotuhi M., Dawson T. M., and Snyder S. H. (1991) Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 1, 615-624.
    • (1991) Neuron , vol.1 , pp. 615-624
    • Bredt, D.S.1    Glatt, C.E.2    Hwang, P.M.3    Fotuhi, M.4    Dawson, T.M.5    Snyder, S.H.6
  • 5
    • 0030930826 scopus 로고    scopus 로고
    • Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity
    • Di Monte D. A., Royland J. E., Anderson A., Castagnoli K., Castagnoli N. Jr., and Langston J. W. (1997) Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity. J. Neurochem. 69, 1771-1773.
    • (1997) J. Neurochem. , vol.69 , pp. 1771-1773
    • Di Monte, D.A.1    Royland, J.E.2    Anderson, A.3    Castagnoli, K.4    Castagnoli N., Jr.5    Langston, J.W.6
  • 7
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • Gonzalez-Scarano F. and Baltuch C. (1999) Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22, 219-240.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, C.2
  • 9
    • 0029844003 scopus 로고    scopus 로고
    • Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons
    • Hantraye P., Brouillet E., Ferrante R., Palfi S., Dolan R., Matthews R. T., and Beal M. F. (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat. Med. 2, 1017-1021.
    • (1996) Nat. Med. , vol.2 , pp. 1017-1021
    • Hantraye, P.1    Brouillet, E.2    Ferrante, R.3    Palfi, S.4    Dolan, R.5    Matthews, R.T.6    Beal, M.F.7
  • 10
    • 2642605346 scopus 로고    scopus 로고
    • Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-α/lipopolysaccharide
    • Heneka M. T., Löschmann P.-A., Gleichmann M., Weller M., Schulz J. B., Wüllner U., and Klockgether T. (1998) Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-α/lipopolysaccharide. J. Neurochem. 71, 88-94.
    • (1998) J. Neurochem. , vol.71 , pp. 88-94
    • Heneka, M.T.1    Löschmann, P.-A.2    Gleichmann, M.3    Weller, M.4    Schulz, J.B.5    Wüllner, U.6    Klockgether, T.7
  • 11
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • Hirsch E. C., Hunot S., Damier P., and Faucheux B. (1998) Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann. Neurol. 44 (Suppl.), S115-S120.
    • (1998) Ann. Neurol. , vol.44 , Issue.SUPPL.
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 13
    • 0033121299 scopus 로고    scopus 로고
    • FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells
    • Hunot S., Dugas N., Faucheux B., Hartmann A., Tardieu M., Debre P., Agid Y., Dugas B., and Hirsch E. C. (1999) FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J. Neurosci. 19, 3440-3447.
    • (1999) J. Neurosci. , vol.19 , pp. 3440-3447
    • Hunot, S.1    Dugas, N.2    Faucheux, B.3    Hartmann, A.4    Tardieu, M.5    Debre, P.6    Agid, Y.7    Dugas, B.8    Hirsch, E.C.9
  • 14
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J. W., Forno L. S., Tetrud J., Reeves A. G., Kaplan J. A., and Karluk D. (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46, 598-605.
    • (1999) Ann. Neurol. , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 15
    • 0028889439 scopus 로고
    • Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death
    • Laubach V. E., Shesely E. G., Smithies O., and Sherman P. A. (1995) Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. USA 92, 10688-10692.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10688-10692
    • Laubach, V.E.1    Shesely, E.G.2    Smithies, O.3    Sherman, P.A.4
  • 17
    • 0031079599 scopus 로고    scopus 로고
    • S-methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity
    • Matthews R. T., Yang L., and Beal M. F. (1997) S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. Exp. Neurol. 143, 282-286.
    • (1997) Exp. Neurol. , vol.143 , pp. 282-286
    • Matthews, R.T.1    Yang, L.2    Beal, M.F.3
  • 18
    • 0027294047 scopus 로고
    • Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: Antinociceptive and cardiovacular effects
    • Moore P. K., Wallace P., Gaffen Z., Hart S. L., and Babbedge R. C. (1993) Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovacular effects. Br. J. Pharmacol. 110, 219-224.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 219-224
    • Moore, P.K.1    Wallace, P.2    Gaffen, Z.3    Hart, S.L.4    Babbedge, R.C.5
  • 19
    • 0033521095 scopus 로고    scopus 로고
    • Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and O,O′-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease
    • Pennathur S., Jackson-Lewis V., Przedborski S., and Heinecke J. W. (1999) Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and O,O′-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. J. Biol. Chem. 274, 34621-34628.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34621-34628
    • Pennathur, S.1    Jackson-Lewis, V.2    Przedborski, S.3    Heinecke, J.W.4
  • 20
    • 0029984860 scopus 로고    scopus 로고
    • Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
    • Przedborski S., Jackson-Lewis V., Yokoyama R., Shibata T., Dawson V. L., and Dawson T. M. (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc. Natl. Acad. Sci. USA 93, 4565-4571.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4565-4571
    • Przedborski, S.1    Jackson-Lewis, V.2    Yokoyama, R.3    Shibata, T.4    Dawson, V.L.5    Dawson, T.M.6
  • 21
    • 0029592641 scopus 로고
    • Role of nitric oxide in neurodegenerative diseases
    • Schulz J. B., Matthews R. T., and Beal M. F. (1995a) Role of nitric oxide in neurodegenerative diseases. Curr. Opin. Neurol. 8, 480-486.
    • (1995) Curr. Opin. Neurol. , vol.8 , pp. 480-486
    • Schulz, J.B.1    Matthews, R.T.2    Beal, M.F.3
  • 22
    • 0028796770 scopus 로고
    • Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice
    • Schulz J. B., Matthews R. T., Muqit M. M. K., Browne S. E., and Beal M. F. (1995b) Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J. Neurochem. 64, 936-939.
    • (1995) J. Neurochem. , vol.64 , pp. 936-939
    • Schulz, J.B.1    Matthews, R.T.2    Muqit, M.M.K.3    Browne, S.E.4    Beal, M.F.5
  • 23
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining
    • Tatton N. A. and Kish S. J. (1997) In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77, 1037-1048.
    • (1997) Neuroscience , vol.77 , pp. 1037-1048
    • Tatton, N.A.1    Kish, S.J.2
  • 24
    • 0027504297 scopus 로고
    • Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds
    • Tipton K. F. and Singer T. P. (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61, 1191-1206.
    • (1993) J. Neurochem. , vol.61 , pp. 1191-1206
    • Tipton, K.F.1    Singer, T.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.