Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6204-6208

  Menchise, Valeria ^a   Simone, Giuseppina De ^a   Fiore, Anna Di ^a   Scozzafava, Andrea ^b   Supuran, Claudiu T ^b  

^a CNR   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

1,3,4 Thiadiazole; Carbonic anhydrase; Enzyme inhibitor; Sulfonamide; X ray crystallography

Indexed keywords

5 (4 AMINO 3 CHLORO 5 FLUOROPHENYLSULFONAMIDO) 1,3,4 THIADIAZOLE 2 SULFONAMIDE; 5 AMINO 1,3,4 THIADIAZOLE 2 SULFONAMIDE; BENZENE DERIVATIVE; CARBONATE DEHYDRATASE INHIBITOR; GLUTAMIC ACID; ISOENZYME; LEUCINE; PHENYLALANINE; PROLINE; SULFONAMIDE; THIADIAZOLE DERIVATIVE; THREONINE; UNCLASSIFIED DRUG; VALINE; ZINC ION;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; DRUG STRUCTURE; HYDROPHOBICITY; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIADIAZOLES;

EID: 33750703618     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.022     Document Type: Article

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