Granzyme B is a novel interleukin-18 converting enzyme

Journal of Dermatological Science

Volumn 59, Issue 2, 2010, Pages 129-135

  Omoto, Youichi ^a   Yamanaka, Keiichi ^a   Tokime, Kazuya ^a   Kitano, Shigehisa ^a   Kakeda, Masato ^a   Akeda, Tomoko ^a   Kurokawa, Ichiro ^a   Gabazza, Esteban C ^a   Tsutsui, Hiroko ^b   Katayama, Naoyuki ^a   Yamanishi, Kiyofumi ^b   Nakanishi, Kenji ^b   Mizutani, Hitoshi ^a  

^a MIE UNIVERSITY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Apoptosis.; Cytokine; Inflammation; Skin

Indexed keywords

CASPASE; DIPEPTIDYL CARBOXYPEPTIDASE; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 18; INTERLEUKIN 18 CONVERTING ENZYME; PERFORIN; PROTEINASE; RECOMBINANT INTERLEUKIN 18; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CD8+ T LYMPHOCYTE; CELL DIVISION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; ENZYME PURIFICATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; APOPTOSIS; CASPASE 1; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; GRANZYMES; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-18; KERATINOCYTES; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA;

EID: 77955050873     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2010.05.004     Document Type: Article

References (47)

1. Nakanishi K., Yoshimoto T., Tsutsui H., Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001, 12:53-72.
2. Nakanishi K., Yoshimoto T., Tsutsui H., Okamura H. Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 2001, 19:423-474.
3. Ghayur T., Banerjee S., Hugunin M., Butler D., Herzog L., Carter A., et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997, 386:619-623.
4. Gu Y., Kuida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 1997, 275:206-209.
5. Gaggero A., De Ambrosis A., Mezzanzanica D., Piazza T., Rubartelli A., Figini M., et al. A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing. Oncogene 2004, 23:7552-7560.
6. Omoto Y., Tokime K., Yamanaka K., Habe K., Morioka T., Kurokawa I., et al. Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. J Immunol 2006, 177:8315-8319.
7. Harris J.L., Peterson E.P., Hudig D., Thornberry N.A., Craik C.S. Definition and redesign of the extended substrate specificity of granzyme B. J Biol Chem 1998, 273:27364-27373.
8. Waugh S.M., Harris J.L., Fletterick R., Craik C.S. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity. Nat Struct Biol 2000, 7:762-765.
9. Jenne D.E., Tschopp J. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation. Immunol Rev 1988, 103:53-71.
10. Berke G. Unlocking the secrets of CTL and NK cells. Immunol Today 1995, 16:343-346.
11. Trapani J.A., Smyth M.J. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2002, 2:735-747.
12. Froelich C.J., Hanna W.L., Poirier G.G., Duriez P.J., D'Amours D., Salvesen G.S., et al. Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun 1996, 227:658-665.
13. Song Q., Lees-Miller S.P., Kumar S., Zhang Z., Chan D.W., Smith G.C., et al. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J 1996, 15:3238-3246.
14. Andrade F., Roy S., Nicholson D., Thornberry N., Rosen A., Casciola-Rosen L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 1998, 8:451-460.
15. Duriez P.J., Shah G.M. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol 1997, 75:337-349.
16. Graubert T.A., Russell J.H., Ley T.J. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood 1996, 87:1232-1237.
17. Park H.J., Kim J.E., Lee J.Y., Cho B.K., Lee W.J., Kim T., et al. Increased expression of IL-18 in cutaneous graft-versus-host disease. Immunol Lett 2004, 95:57-61.
18. Yawalkar N., Schmid S., Braathen L.R., Pichler W.J. Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis. Br J Dermatol 2001, 144:1133-1139.
19. Yawalkar N., Hunger R.E., Buri C., Schmid S., Egli F., Brand C.U., et al. A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B. Am J Pathol 2001, 158:803-808.
20. Muller S., Lory J., Corazza N., Griffiths G.M., Z'Graggen K., Mazzucchelli L., et al. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. Am J Pathol 1998, 152:261-268.
21. Leon A.J., Gomez E., Garrote J.A., Bernardo D., Barrera A., Marcos J.L., et al. High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD. Mediat Inflamm 2009, 2009:580450.
22. Homs S., Mansour H., Desvaux D., Diet C., Hazan M., Buchler M., et al. Predominant Th1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy. Am J Transplant 2009, 9:1230-1236.
23. Striz I., Krasna E., Honsova E., Lacha J., Petrickova K., Jaresova M., et al. Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft. Immunol Lett 2005, 99:30-35.
24. Spaeny-Dekking E.H., Hanna W.L., Wolbink A.M., Wever P.C., Kummer A.J., Swaak A.J., et al. Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol 1998, 160:3610-3616.
25. Poe M., Blake J.T., Boulton D.A., Gammon M., Sigal N.H., Wu J.K., et al. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity. J Biol Chem 1991, 266:98-103.
26. Talanian R.V., Dang L.C., Ferenz C.R., Hackett M.C., Mankovich J.A., Welch J.P., et al. Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme. J Biol Chem 1996, 271:21853-21858.
27. Fynbo C.H., Lorentsen R.H., Etzerodt M., Thogersen H.C., Holtet T.L. Characterization of a recombinant granzyme B derivative as a " restriction" protease. Protein Expr Purif 2005, 39:209-218.
28. Yamin T.T., Ayala J.M., Miller D.K. Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme. J Biol Chem 1996, 271:13273-13282.
29. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 1997, 272:17907-17911.
30. Backes C., Kuentzer J., Lenhof H.P., Comtesse N., Meese E. GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences. Nucleic Acids Res 2005, 33:W208-W213.
31. Konishi H., Tsutsui H., Murakami T., Yumikura-Futatsugi S., Yamanaka K., Tanaka M., et al. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci USA 2002, 99:11340-11345.
32. Yamanaka K., Tanaka M., Tsutsui H., Kupper T.S., Asahi K., Okamura H., et al. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol 2000, 165:997-1003.
33. Yoshimoto T., Mizutani H., Tsutsui H., Noben-Trauth N., Yamanaka K., Tanaka M., et al. IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 2000, 1:132-137.
34. Mizutani H., Schechter N., Lazarus G., Black R.A., Kupper T.S. Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med 1991, 174:821-825.
35. Mee J.B., Alam Y., Groves R.W. Human keratinocytes constitutively produce but do not process interleukin-18. Br J Dermatol 2000, 143:330-336.
36. Nguyen K.D., Vanichsarn C., Nadeau K.C. Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma. Eur J Immunol 2008, 38:2034-2045.
37. Reading P.C., Whitney P.G., Barr D.P., Wojtasiak M., Mintern J.D., Waithman J., et al. IL-18, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type 1 infection. J Immunol 2007, 179:3214-3221.
38. Hyodo Y., Matsui K., Hayashi N., Tsutsui H., Kashiwamura S., Yamauchi H., et al. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. J Immunol 1999, 162:1662-1668.
39. Inachi S., Mizutani H., Shimizu M. Epidermal apoptotic cell death in erythema multiforme and Stevens-Johnson syndrome. Contribution of perforin-positive cell infiltration. Arch Dermatol 1997, 133:845-849.
40. Lauw F.N., Simpson A.J., Hack C.E., Prins J.M., Wolbink A.M., van Deventer S.J., et al. Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. J Infect Dis 2000, 182:206-213.
41. Tak P.P., Spaeny-Dekking L., Kraan M.C., Breedveld F.C., Froelich C.J., Hack C.E. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol 1999, 116:366-370.
42. Fujino M., Kawasaki M., Funeshima N., Kitazawa Y., Kosuga M., Okabe K., et al. CrmA gene expression protects mice against concanavalin-A-induced hepatitis by inhibiting IL-18 secretion and hepatocyte apoptosis. Gene Ther 2003, 10:1781-1790.
43. Miura Y., Thoburn C.J., Bright E.C., Hess A.D. Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand. Biol Blood Marrow Transplant 2004, 10:156-170.
44. Oberbauer R. Biomarkers-a potential route for improved diagnosis and management of ongoing renal damage. Transplant Proc 2008, 40:S44-S47.
45. Ayello J., van de Ven C., Cairo E., Hochberg J., Baxi L., Satwani P., et al. Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: implications for adoptive cellular immunotherapy. Exp Hematol 2009, 37:1216-1229.
46. Darmon A.J., Ehrman N., Caputo A., Fujinaga J., Bleackley R.C. The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme. J Biol Chem 1994, 269:32043-32046.
47. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257.