Predominant Th1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy

American Journal of Transplantation

Volumn 9, Issue 5, 2009, Pages 1230-1236

  Homs, S ^a   Mansour, H ^a   Desvaux, D ^a   Diet, C ^a   Hazan, M ^c   Buchler, M ^b   Lebranchu, Y ^b   Buob, D ^d   Badoual, C ^e   Matignon, M ^a   Audard, V ^a   Lang, P ^a   Grimbert, P ^a  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITÉ DE TOURS   (France)

^c Lille Nord de France University (EA 2694)   (France)

^d LILLE UNIVERSITY HOSPITAL   (France)

^e HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

Chronic transplant glomerulopathy; Immune function; Renal transplant; Renal transplant pathology

Indexed keywords

AZATHIOPRINE; BIOLOGICAL MARKER; CD20 ANTIGEN; CYCLOSPORIN A; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ADULT; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; GLOMERULOPATHY; GRAFT RECIPIENT; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; MALE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL;

CAPILLARIES; DNA, COMPLEMENTARY; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TRANSPLANTATION; PHENOTYPE; POSTOPERATIVE COMPLICATIONS; RENAL CIRCULATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS;

EID: 65249177814     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02596.x     Document Type: Article

References (21)

1. Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999 55 : 713 723.
2. Sis B, Campbell PM, Mueller T et al. Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause. Am J Transplant 2007 7 : 1743 1752.
3. Cosio FG, Gloor JM, Sethi S, Stegall MD. Transplant glomerulopathy. Am J Transplant 2008 8 : 492 496. Review.
4. Calvin RB. Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis. Am Soc Nephrol 2007 18 : 1046 1056. Review.
5. Akalin E, Dikman S, Murphy B, Bromberg JS, Hancock WW. Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy. Am J Transplant 2003 3 : 1116 1120.
6. Magil AB. Infiltrating cell types in transplant glomerulitis: Relationship to peritubular capillary C4d deposition. Am J Kidney Dis 2005 45 : 1084 1089.
7. Goriely S, Goldman M. The interleukin-12 family: New players in transplantation immunity. Am J Transplant 2007 7 : 278 284.
8. Long E, Wood KG. Understanding FOXP3: Progress towards achieving transplantation tolerance. Transplantation 2007 84 : 459 461.
9. Antonysamy MA, Fanslow WC, Fu F et al. Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. J Immunol 1999 162 : 577 584.
10. Singh NP, Guo L, Mhoyan A, Shirwan H. Predominant expression of Th2 cytokines and interferon-gamma in xenogeneic cardiac grafts undergoing acute vascular rejection. Transplantation 2003 75 : 586 590.
11. Solez K, Colvin RB, Racusen LC et al. Banff '07 Classification of renal allograft pathology: Updates and futures direction. Am J Transplant 2008 8 : 753 760.
12. Callard RE. Decision-making by the immune response. Immunol and Cell Biol 2007 85 : 300 305.
13. Rogge L, Barberis-Maino L, Biffi M et al. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 1997 185 : 825 831.
14. Lehar SM, Bevan MJ. Immunology: Polarizing a T-cell response. Nature 2004 430 : 150 151.
15. Al Aly Z, Yalamanchili P, Cortese C, Salinas-Madrigal L, Bastani B. C4d peritubular capillary staining in chronic allograft nephropathy and transplant glomerulopathy: An uncommon finding. Transpl Int 2005 18 : 800 805.
16. Nickeleit V, Zeiler M, Gudat F, Thiel G, Mihatsch MJ. Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002 13 : 242 251.
17. Rotman S, Collins AB, Colvin RB. C4d deposition in allograft: Current concepts and interpretation. Transplant Rev 2005 19 : 65 77.
18. Habib R, Zurowska A, Hinglais N et al. A specific glomerular lesion of the graft: Allograft glomerulopathy. Kidney Int 1993 42 : S104 S111.
19. Loong CC, Hsieh HG, Lui WY, Chen A, Lin CY. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 2002 197 : 322 332.
20. Mangan PR, Harrington LE, O'Quinn DB et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006 441 : 231 234.
21. Mueller TF, Einecke G, Reeve J et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant. 2007 12 : 2712 2722.