The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

Nature Structural Biology

Volumn 7, Issue 9, 2000, Pages 762-765

  Waugh, Sandra M ^a   Harris, Jennifer L ^a,b   Fletterick, Robert ^a,c   Craik, Charles S ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; PROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; ASPARTIC ACID; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; GLYCOSYLATION; GRANZYMES; HUMANS; MODELS, MOLECULAR; MUTATION; PERIPLASMIC PROTEINS; PROTEIN CONFORMATION; RATS; SEQUENCE ALIGNMENT; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 0033818886     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/78992     Document Type: Article

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