Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria

Journal of Infectious Diseases

Volumn 182, Issue 1, 2000, Pages 206-213

  Lauw, Fanny N ^a   Simpson, Andrew J H ^c,e   Hack, C Erik ^b   Prins, Jan M ^a   Wolbink, Angela M ^b   Van Deventer, Sander J H ^a   Chaowagul, Wipada ^d   White, Nicholas J ^c,e   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b CENTRAL LABORATORY   (Netherlands)

^c MAHIDOL UNIVERSITY   (Thailand)

^d Sappasitthiprasong Hospital   (Thailand)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANZYME A; GRANZYME B; INTERLEUKIN 12; INTERLEUKIN 18; TUMOR NECROSIS FACTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; BURKHOLDERIA PSEUDOMALLEI; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOTOXEMIA; ENZYME RELEASE; FEMALE; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CYTOKINES; ENDOTOXEMIA; FEMALE; FOLLOW-UP STUDIES; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRANZYMES; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MELIOIDOSIS; MIDDLE AGED; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS;

EID: 0033914223     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315642     Document Type: Article

References (28)

1. 1. Berke G. Unlocking the secrets of CTL and NK cells. Immunol Today 1995;16:343-6.
2. 2. Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996;14:207-32.
3. 3. Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity 1999;10:595-605.
4. 4. Pinkoski MJ, Hobman M, Heibein JA, et al. Entry and trafficking of granzyme B in target cells during granzyme B perforin mediated apoptosis. Blood 1998;92:1044-54.
5. 5. Shi L, Kam CM, Powers JC, Aebersold R, Greenberg AH. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med 1992; 176:1521-9.
6. 6. Smyth MJ, Trapani JA. Granzymes: exogenous proteinases that induce target cell apoptosis. Immunol Today 1995;16:202-6.
7. 7. Froelich CJ, Dixit VM, Yang X. Lymphocyte granule mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today 1998;19: 30-6.
8. 8. Takayama H, Trenn G, Humphrey W Jr, Bluestone JA, Henkart PA, Sitkovsky MV. Antigen receptor triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes. J Immunol 1987;138:566-9.
9. 9. Isaaz S, Baetz K, Olsen K, Podack E, Griffiths GM. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules, and secretion of lytic proteins via a non-granule pathway. Eur J Immunol 1995;25:1071-9.
10. 10. Spaeny-Dekking EA, Hanna WL, Wolbink AM, et al. Extracellular granzymes A and B in man: detection of native species during CTL responses in vitro and in vivo. J Immunol 1998;160:3610-6.
11. 11. Wever PC. Spaeny LHA, van der Vliet HJJ, et al. Expression of granzyme B during primary Cytomegalovirus infection after renal transplantation. J Infect Dis 1999;179:693-6.
12. 12. Tak PP, Spaeny-Dekking L, Kraan MC, Breedveld FC, Froelich CJ, Hack CE. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol 1999;116:366-70.
13. 13. van der Poll T, van Deventer SJH. Endotoxemia in healthy subjects as a human model of inflammation. In: Cohen J, Marshall J, eds. The immune response in the critically ill. New York: Springer-Verlag, 1999:335-57.
14. 14. Chaowagul W, White NJ, Dance DAB, et al. Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand. J Infect Dis 1989;159:890-9.
15. 15. Simpson AJH, Suputtamongkol Y, Smith MD, et al. Comparison of imipenem and ceftazidime as therapy for severe melioidosis. Clin Infect Dis 1999;29:381-7.
16. 16. Simpson AJ, Opal SM, Angus BJ, et al. Differential antibiotic-induced endotoxin release in severe melioidosis. J Infect Dis 2000;181:1014-9.
17. 17. Lauw FN, Simpson AJH, Prins JM, et al. Elevated plasma concentrations of interferon-γ (IFN-γ) and the IFN-γ inducing cytokines interleukin-18 (IL-18), IL-12, and IL-15 in severe melioidosis. J Infect Dis 1999;180: 1878-85.
18. 18. Suputtamongkol Y, Kwiatkowski D, Dance DAB, Chaowagul W. White NJ. Tumor necrosis factor in septicemic melioidosis. J Infect Dis 1992;165: 561-4.
19. 19. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-76.
20. 20. Dinarello CA. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 1999;103:11-24.
21. 21. Lauw FN, Te Velde AA, Dekkers PEP, et al. Activation of mononuclear cells by interleukin-12: an in vivo study in chimpanzees. J Clin Immunol 1999;19:231-8.
22. 22. Osaki T, Peron JM, Cai Q, et al. IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma-and IL-12-independent antitumor effects. J Immunol 1998;160:1742-9.
23. 23. Yoshida Y, Tasaki K, Kimurai M, et al. Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells. Anticancer Res 1998;18:333-5.
24. 24. Car BD, Eng VM, Schnyder B, et al. Role of interferon-gamma in interleukin 12-induced pathology in mice. Am J Pathol 1995;147:1693-707.
25. 25. Robinson D, Shibuya K, Mui A, et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFκB. Immunity 1997;7:571-81.
26. 26. Lauw FN, Pajkrt D, Hack CE, Kurimoto M, van Deventer SJH, van der Poll T. Proinflammatory effects of interleukin-10 (IL-10) during human endotoxemia [abstract 270]. In: Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco). Washington, DC: American Society for Microbiology, 1999.
27. 27. Sower LE, Klimpel GR, Hanna W, Froelich CJ. Extracellular activities of human granzymes. I. Granzyme A induces IL-6 and IL-8 production in fibroblast and epithelial cell lines. Cell Immunol 1996;171:159-63.
28. 28. Sower LE, Froelich CJ, Allegretto N, Rose PM, Hanna WD, Klimpel GR. Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol 1996;156:2585-90.