A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: Spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B

American Journal of Pathology

Volumn 158, Issue 3, 2001, Pages 803-808

  Yawalkar, Nikhil ^a   Hunger, Robert E ^a   Buri, Caroline ^a   Schmid, Simone ^a   Egli, Fabienne ^a   Brand, Christoph U ^a   Mueller, Christoph ^a   Pichler, Werner J ^a   Braathen, Lasse R ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GRANZYME B; PERFORIN;

ADULT; ARTICLE; CELL DAMAGE; CLINICAL ARTICLE; CONTACT ALLERGY; CONTACT DERMATITIS; CONTROLLED STUDY; EPIDERMIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; IN VIVO STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PSORIASIS; SKIN ALLERGY; SKIN BIOPSY;

EID: 0035101530     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64027-8     Document Type: Article

References (23)

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3. Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses: Evidence for the presence of effector CD8+ and regulatory CD4+ T cells
4. MHC-dependent and -independent activation of human nickel-specific CD8+ cytotoxic T cells from allergic donors
5. Contact hypersensitivity in MHC class II-deficient mice depends on CD8 T lymphocytes primed by immunostimulating Langerhans cells
6. Major histocompatibility complex class I-restricted CD8+ T cells and class II-restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene
7. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity
8. A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor
9. Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions
10. The cell biology of CTL killing
11. Perforin: Structure and function
12. Family of serine esterases in lyric granules of cytolytic T lymphocytes
13. Cell-mediated cytotoxic mechanisms
14. Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B
15. Pathophysiology of drug-elicited exanthema
16. T cell cytotoxicity in sulfamethoxazole induced skin reaction
17. Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A
18. Cytolytic effector mechanisms of human CD4+ cytotoxic T lymphocytes
19. Human autoreactive CD4+ T cell clones use perforin- or Fas/Fas ligand-mediated pathways for target cell lysis
20. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: Interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (II) 4/II-10-producing (Th2) negative regulatory CD4+ T cells
21. CD4(+) Th1 and CD8(+) type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity
22. Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans
23. T cell mediated FAS-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis