Statistical analysis of interactive cytotoxicity in human epidermal keratinocytes following exposure to a mixture of four metals

Journal of Agricultural, Biological, and Environmental Statistics

Volumn 7, Issue 1, 2002, Pages 58-73

  Gennings, Chris ^a   Carter Jr , Walter H ^a   Campain, Julie A ^b   Bae, Dong Soon ^b   Yang, Raymond S H ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Simultaneous inference; Synergism

Indexed keywords

COMPARATIVE STUDY; STATISTICAL ANALYSIS; TOXICITY;

EID: 0003067199     PISSN: 10857117     EISSN: None     Source Type: Journal    
DOI: 10.1198/108571102317475062     Document Type: Article

References (31)

1. ATSDR. (1997), 7997 CERCLA Priority List of Hazardous Substances That Will Be the Subjects of Toxicological Profiles and Support Document, Washington, DC: Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services.
2. Berenbaum, M. C. (1985), "The Expected Effect of a Combination of Agents: The General Solution," Journal of Theoretical Biology, 114, 413-431.
3. Berenbaum, M. C. (1989), "What Is Synergy?" Pharmacological Reviews, 41, 93-141.
4. Calabrese, E. J. (1997), "Hormesis Revisited: New Insights Concerning the Biological Effects of Low-Dose Exposures to Toxins," Environmental Law Reporter, 27, 10526-19532.
5. Calabrese, E. J., and Baldwin, L. A. (1997a), "The Dose Determines the Stimulation (and Poison): Development of a Chemical Hormesis Database," International Journal of Toxicology, 16, 545-559.
6. (1997b), "A Quantitatively-Based Methodology for the Evaluation of Chemical Hormesis," Human Ecological Risk Assessment, 3, 545-554.
7. Choi, E. J., Toscano, D. G., Ryan, J. A., Riedel, N., and Toscano, W. A. (1991), "Dioxin Induces Transforming Growth Factor-α in Human Keratinocytes," Journal of Biological Chemistry, 266, 9591-9597.
8. Cohen, M. D., Kargacin, C. B., Klein, C. B., and Costa, M. (1993), "Mechanisms of Chromium Carcinogenicity and Toxicity," Critical Reviews in Toxicology, 23, 255-281.
9. De Rosa, C. T., Johnson, B. L., Fay, M., Hansen, H., and Mumtaz, M. M. (1996), "Public Health Implications of Hazardous Waste Sites: Findings, Assessment and Research," Food and Chemical Toxicology, 34, 1131-1138.
10. Fay, R. M., and Mumtaz, M. M. (1996), "Development of a Priority List of Chemical Mixtures Occurring at 1188 Hazardous Waste Sites, Using the HazDat Database," Food and Chemical Toxicology, 34, 1163-1165.
11. Gaido, K. W., Maness, S. C., Leonard, L. S., and Greenlee, W. F. (1992), "2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Dependent Regulation of Transforming Growth Factors-α and β2 Expression in a Human Keratinocyte Cell Line Involves Both Transcriptional and Posttranscriptional Control," Journal of Biological Chemistry, 267, 245591-24595.
12. Gennings, C., and Carter, W. H., Jr., (1995), "Utilizing Concentration-Response Data From Individual Components to Detect Statistically Significant Departures From Additivity in Chemical Mixtures," Biometrics, 51, 1264-1277.
13. Gennings, C., Schwartz, P., Carter, W. H., Jr., and Simmons, J. E. (1997), "Detection of Departures From Additivity in Mixtures of Many Chemicals With a Threshold Model," Journal of Agricultural, Biological, and Environmental Statistics, 2, 198-211.
14. Germolec, D. R., Spalding, J., Boorman, G. A., Wilmer, J. L., Yoshida, T., Simeonova, P. P., Bruccoleri, A., Kayama, F., Gaido, K., Tennant, R., Burleson, F., Dong, W., Lang, R. W., and Luster, M. I. (1997), "Arsenic Can Mediate Skin Neoplasia by Chronic Stimulation of Keratinocyte-Derived Growth Factors," Mutation Research. 386, 209-218.
15. Germolec, D. R., Yoshida, T., Gaido, K., Wilmer, J. L., Simeonova, P. P., Kayama, F., Burleson, F., Dong, W., Lange, R. W., and Luster, M. I. (1996), "Arsenic Induces Overexpression of Growth Factors in Human Keratinocytes," Toxicology Applied Pharmacology, 141, 308-318.
16. Glick, A. B., Lee, M. M., Darwiche, N., Kulkarni, A. B., Karlsson, S., and Yuspa, S. H. (1994), "Targeted Deletion of the TGFβ1 Gene Causes Rapid Progression to Squamous Cell Carcinoma," Genes Development, 8, 2429-2440.
17. Glick, A. B., Sporn, M. B., and Yuspa, S. H. (1991), "TGF-β1 and TGF-α in Primary Keratinocytes and Papillomas Expressing v-Ha-ras," Molecular Carcinogenicity, 4, 210-219.
18. Hochberg, Y. (1990). "A Sharper Bonferroni Procedure for Multiple Tests of Significance," Biometrika, 75, 800-802.
19. Kachinskas, D. J., Qin, Q., Phillips, M. A., and Rice, R. H. (1997), "Arsenic Suppression of Human Keratinocyte Programming," Mutation Research, 386, 253-261.
20. Kelly, C., and Rice, J. (1990), "Monotone Smoothing With Application to Dose-Response Curves and the Assessment of Synergism," Biometrics, 46, 1071-1085.
21. Loewe, S. (1953), "The Problem of Synergism and Antagonism of Combined Drugs," Arzncimittle Forshung, 3, 285-290.
22. Loewe, S., and Muischnek, H. (1926), "Uber Kombinationswirkunger. I. Mitteilung: Hilfsmittel der gragstellung. Naunyn-Schmiedebergs,"Archives of pharmacology, 114, 313-326.
23. Miller, R. J., Jr. (1981), Simultaneous Statistical Inference (2nd ed.), New York: McGraw Hill.
24. Mosmann, T. (1983), "Rapid Colorimetric Assay for Cellular Growth and Survivals: Application to Proliferation and Cytotoxicity Assays," Journal of Immunological Methods, 65, 55-63.
25. Pietenpol, J. A., Holt, J. T., Stein, R. W., and Moses, H. L. (1990), 'Transforming Growth Factor β1-Suppression of c-myc Gene Transcription: Role in Inhibition of Keratinocyte Proliferation," Proceedings of the National Academy of Sciences, USA, 87, 53-65.
26. Punnonen, K., Denning, M. F., Rhee, S. G., and Yuspa, S. H. (1994), "Differences in the Regulation of Phosphatidylinositol-Specific Phospholipase C in Normal and Neoplastic Keratinocytes," Molecular Carcinogenicity, 10, 216-225.
27. Seber, G. A., and Wild, C. J. (1989), Nonlinear Regression, New York: Wiley.
28. Stebbing, A. R. D. (1982), "Hormesis-The Stimulation of Growth by Low Levels of Inhibitors." Science of the Total Environment, 22, 213-234.
29. (1997), "A Theory for Growth Hormesis," BELLE Newsletter. 6, 1-11.
30. Ye, J., Zhang, X., Young, H. A., Mao, Y., and Shi, X. (1995), "Chromium(VI)-Induced Nuclear Factor-kB Activation in Intact Cells Via Free Radical Reactions," Carcinogenesis, 16, 2401-2405.
31. Yen, H.-T., Chiang, L.-C., Wen, K.-H., Chang, S.-F., Tsai, C.-C., Yu, C.-L., and Yu, H.-S. (1996), "Arsenic Induces Interleukin-8 Expression in Cultured Keratinocytes." Archives Dermatological Research, 288, 716-717.