Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons

Toxicology and Applied Pharmacology

Volumn 161, Issue 3, 1999, Pages 249-257

  Haddad, Sami ^a   Tardif, Robert ^a   Charest Tardif, Ginette ^a   Krishnan, Kannan ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

BTEX; Interactions; Mixtures; PBPK; PBTK; Physiological modeling

Indexed keywords

BENZENE; ETHYLBENZENE; META XYLENE; TOLUENE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; EXPOSURE; HEART OUTPUT; INHALATION; KINETICS; LIVER; LUNG VENTILATION; MALE; METABOLIC INHIBITION; MODEL; MOLECULAR INTERACTION; NONHUMAN; PARTITION COEFFICIENT; RAT; RISK ASSESSMENT; TOXICOKINETICS;

ANIMALIA;

EID: 0033572851     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8803     Document Type: Article

References (28)

1. Andersen M. E., Gargas M. L., Clewell H. J. III, Severin K. M. Quantitative evaluation of the metabolic interaction between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods. Toxicol. Appl. Pharmacol. 89:1987;149-157.
2. Arms, A. D, and, Travis, C. C. 1988, Reference physiological parameters in pharmacokinetic modeling. NTIS PB 88-196019, Office of Risk Analysis, U.S. EPA, Washington, D.C.
3. Chen C. T. Understanding the fate of petroleum hydrocarbons in the subsurface environment. J. Chem. Edu. 69:1992;357-361.
4. El-Masri H. A., Constan A. A., Ramsdell H. S., Yang R. S. H. Physiologically-based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fisher 344 rats. Toxicol. Appl. Pharmacol. 141:1996a;124-132.
5. El-Masri H. A., Tessari J. D., Yang R. S. H. Exploration of an interaction threshold for the joint toxicity of trichloroethylene and 1,1-dichloroethylene: utilization of a PBPK model. Arch. Toxicol. 70:1996b;527-539.
6. Guengerich F. P., Kim D. H., Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspect. Chem. Res. Toxicol. 4:1991;168-179.
7. Krishnan, K., Andersen, M. E., Clewell, H. J. III, and Yang, R. S. H.1994. Physiologically based pharmacokinetic modeling of chemical mixtures. In Toxicology of Chemical Mixtures (R. S. H. Yang, Ed.), pp. 399-437. Academic Press, NY.
8. Liira J., Eolvaara R., Raunio H., Riihimaki V., Engstrom K. Metabolic interaction and disposition of methylethyl ketone and m-xylene in rats at single and repeated exposures. Xenobiotica. 21:1991;53-65.
9. Nakajima T., Elovaara E., Park S. S., Gelboin H. V., Hietanen E., Vainio H. Immunochemical characterization of P-450 isozymes responsible for benzene oxidation in the rat liver. Carcinogenesis. 10:1989;1713-1717.
10. Nakajima T., Elovaara E., Park S. S., Gelboin H. V., Hietanen E., Vainio H. Monoclonal antibody directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism in rat liver microsomes. Biochem. Pharmacol. 40:1990;1255-1261.
11. Nakajima T., Wang R., Elovaara E., Park S. S., Gelboin H. V., Hiltman E., Vainio H. Monoclonal antibody directed characterization of cytochrome P-450 isoenzymes responsible for toluene metabolism in rat liver. Biochem. Pharmacol. 41:1991;395-404.
12. Nakajima T., Wang R. S., Elovaara E., Park S. S., Gelboin H. V., Vainio H. A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem. Pharmacol. 43:1992;251-257.
13. Nakajima T., Wang R. S., Elovaara E., Park S. S., Gelboin H. V., Vainio H. Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes. Biochem. Pharmacol. 45:1993;1079-1085.
14. Office of Underground Storage Tanks, 1990, LUST trust fund monthly progress report, U.S. Environmental Protection Agency, Washington, DC.
15. Pelekis M., Krishnan K. Assessing the relevance of rodent data on chemical interactions for health risk assessment purposes: a case study with dichloromethane-toluene mixture. Regul. Toxicol. Pharmacol. 25:1997;79-86.
16. Purcell K. J., Cason G. H., Gargas M. L., Andersen M. E., Travis C. C. In vivo metabolic interactions of benzene and toluene. Toxicol. Lett. 52:1990;141-152.
17. Ramsey J. C., Andersen M. E. A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:1984;159-175.
18. Sato A., Nakajima T. Dose-dependent metabolic interaction between benzene and toluene in vivo and in vitro. Toxicol. Appl. Pharmacol. 48:1979;249-256.
19. Simmons J. E. Application of physiologically based pharmacokinetic modeling to combination toxicology. Food Chem. Toxicol. 34:1996;1067-1073.
20. Tardif R., Charest-Tardif G., Brodeur J., Krishnan K. Physiologically-based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans. Toxicol. Appl. Pharmacol. 144:1997;120-134.
21. Tardif R., Laparé S., Charest-Tardif G., Brodeur J. Physiologically-based pharmacokinetic modeling of a mixture of toluene and xylene in humans. Risk Anal. 15:1995;335-342.
22. Tardif R., Laparé S., Krishnan K., Brodeur J. Physiologically-based modeling of the toxicokinetic interaction between toluene and xylene in the rat. Toxicol. Appl. Pharmacol. 120:1993;266-273.
23. Tardif R., Plaa G. L., Brodeur J. Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats. Can. J. Physiol. Pharmacol. 70:1992;385-393.
24. Tassaneeyakul W., Birkett D. J., Edwards J. W., Veronese M. E., Tassaneeyakul W., Tukeg R. H., Miners J. O. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. J. Pharmacol. Exp. Ther. 276:1996;101-108.
25. Toftgard R., Nielsen O. G. Effect of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities in rat liver, kidney and lung. Arch. Toxicol. 23:1982;197-212.
26. Travis C. C., Fox M. T., Simmons W. M., Lyon B. F. Co-exposure to gasoline vapor decreases benzene metabolism in Fisher-344 rats. Toxicol. Lett. 62:1992;231-240.
27. Travis C. C., Quillen J. L., Arms A. D. Pharmacokinetics of benzene. Toxicol. Appl. Pharmacol. 102:1990;400-420.
28. Walden T., Spence L. Risk-based BTEX screening criteria for a groundwater irrigation scenario. Hum. Ecol. Risk Assess. 3:1997;699-722.