Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene

Environmental Science and Technology

Volumn 43, Issue 16, 2009, Pages 6341-6348

  Williams, Tim D ^a   Wu, Huifeng ^a   Santos, Eduarda M ^b   Ball, Jon ^b   Katsiadaki, Ioanna ^c   Brown, Margaret M ^d   Baker, Paul ^d   Ortega, Fernando ^a   Falciani, Francesco ^a   Craft, John A ^d   Tyler, Charles R ^b   Chipman, James K ^a   Viant, Mark R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c CENTRE FOR ENVIRONMENT   (United Kingdom)

^d GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMBIENT WATERS; BILE ACID; CYTOCHROME P450; DIBENZANTHRACENE; ENDOCRINE FUNCTIONS; EXPOSURE CONCENTRATION; GASTEROSTEUS ACULEATUS; GENE ONTOLOGY; MALONATES; METABOLIC PATHWAYS; METABOLITE CONCENTRATIONS; METABOLITE PROFILES; METABOLOMICS; MONOOXYGENASES; REAL-TIME PCR;

AROMATIC HYDROCARBONS; BIOACTIVITY; BIOCHEMISTRY; BIOMARKERS; DISSOLUTION; GENE EXPRESSION; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONTOLOGY; POLYCYCLIC AROMATIC HYDROCARBONS;

CONCENTRATION (PROCESS);

ALANINE; BILE ACID; COMPLEMENTARY DNA; CYTOCHROME P450 1A; DIBENZ[A,H]ANTHRACENE; GLUTAMIC ACID; MALONIC ACID; SOLVENT; STEROID; STEROID 21 MONOOXYGENASE; TAURINE; WATER;

AROMATIC HYDROCARBON; BIOMARKER; CONCENTRATION (COMPOSITION); GENE EXPRESSION; METABOLISM; METABOLITE; ORGANIC POLLUTANT; POLLUTION EFFECT; POLLUTION EXPOSURE; TELEOST;

ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOLUTION; DNA MICROARRAY; ENDOCRINE FUNCTION; ENVIRONMENTAL EXPOSURE; FISH; GASTEROSTEUS ACULEATUS; GENE EXPRESSION; GENE INDUCTION; GENETIC ANALYSIS; LIVER; MALE; METABOLITE; METABOLOMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTON NUCLEAR MAGNETIC RESONANCE; REAL TIME POLYMERASE CHAIN REACTION; STEROID METABOLISM; TRANSCRIPTOMICS;

ANIMALS; BENZ(A)ANTHRACENES; ENDOCRINE SYSTEM; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MALE; METABOLIC DETOXICATION, PHASE I; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SMEGMAMORPHA; STEROIDS; TOXICITY TESTS;

GASTEROSTEUS ACULEATUS;

EID: 68849110495     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es9008689     Document Type: Article

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