Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: Identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography

Biomarkers

Volumn 8, Issue 4/3, 2003, Pages 240-271

  Ringeissen, Stephanie ^a   Connor, Susan C ^a   Brown, H Roger ^b   Sweatman, Brian C ^a   Hodson, Mark P ^a   Kenny, Steve P ^a   Haworth, Richard I ^a   McGill, Paul ^a   Price, Mark A ^a   Aylott, Mike C ^a   Nunez, Derek J ^b   Haselden, John N ^a   Waterfield, Catherine J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Biofluid nuclear magnetic resonance spectroscopy; Biomarkers; Metabonomics; Multivariate data analysis; N methyl 4 pyridone 3 carboxamide; N methylnicotinamide; Peroxisome; Peroxisome proliferator activated receptor; Rat plasma; Rat urine

Indexed keywords

4 PYRIDONE DERIVATIVE; CARBOXYLYASE; FENOFIBRATE; MUCONIC ACID; N METHYLNICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; TRYPTOPHAN;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER HYPERTROPHY; LIVER TOXICITY; MALE; MULTIVARIATE ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SENSITIVITY ANALYSIS; STATISTICAL ANALYSIS; URINALYSIS; URINARY EXCRETION;

ANIMALS; BIOLOGICAL MARKERS; CARBOXY-LYASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIGANDS; LIVER; MALE; NIACINAMIDE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEROXISOME PROLIFERATORS; PEROXISOMES; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 12444282758     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1354750031000149124     Document Type: Article

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