Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro

Toxicology and Applied Pharmacology

Volumn 236, Issue 1, 2009, Pages 1-8

  Bosgra, Sieto ^a,b   van Eijkeren, Jan C H ^b   van der Schans, Marcel J ^c   Langenberg, Jan P ^c   Slob, Wout ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Cholinesterase inhibition; Dose additivity; Ellman assay; Interaction; Mixture; N methyl carbamates; Organophosphorus pesticides

Indexed keywords

ACETYLCHOLINESTERASE; METHAMIDOPHOS; METHOMYL;

ARTICLE; CARBAMOYLATION; CHEMICAL INTERACTION; CONTROLLED STUDY; DOSE ADDITIVITY; DOSE RESPONSE; DYNAMICS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; HUMAN; IN VITRO STUDY; MATHEMATICAL MODEL; RISK ASSESSMENT; TOXICODYNAMIC ANALYSIS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; INSECTICIDES; KINETICS; METHOMYL; MODELS, BIOLOGICAL; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHORYLATION; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT;

EID: 61849156330     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.01.002     Document Type: Article

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