Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han rats: Implications for biomarker discovery

Biomarkers

Volumn 9, Issue 2, 2004, Pages 156-179

  Connor, Susan C ^a   Wu, Wen ^a   Sweatman, Brian C ^a   Manini, Jodi ^a   Haselden, John N ^a   Crowther, Daniel J ^a   Waterfield, Catherine J ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

1H NMR; Biomarker; Feeding effects; Hepatotoxicant; Metabonomics; Non specific markers; Weight loss

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 3 HYDROXYBUTYRIC ACID; ALPHA NAPTHYLISOTHIOCYANATE; BILE ACID; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; CREATINE; CREATININE; FATTY ACID; FUMARIC ACID; GLUCOSE; HYDRAZINE; KETONE BODY; N METHYLNICOTINAMIDE; TAURINE; THIOCYANIC ACID DERIVATIVE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMICAL COMPOSITION; BODY FLUID; CITRIC ACID CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE URINE LEVEL; DRUG URINE LEVEL; ENERGY METABOLISM; FACTORIAL ANALYSIS; FATTY ACID OXIDATION; FEEDING BEHAVIOR; FISHER EXACT TEST; GLUCOSE URINE LEVEL; GLYCOLYSIS; IN VIVO STUDY; LIVER TOXICITY; METABOLITE; METHODOLOGY; MULTIVARIATE ANALYSIS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; REGRESSION ANALYSIS; SINGLE DRUG DOSE; STATISTICAL ANALYSIS; TIME PERCEPTION; URINALYSIS; WEIGHT REDUCTION;

1,2-DIMETHYLHYDRAZINE; ANIMALS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CARCINOGENS; ENERGY METABOLISM; HEPATITIS, TOXIC; HYDRAZINES; ISOTHIOCYANATES; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RATS; RATS, WISTAR; URINE; WEIGHT LOSS;

ANIMALIA; MARTES PENNANTI;

EID: 4544326639     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/13547500410001720767     Document Type: Article

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