Structural basis of fatty acid substrate binding to cyclooxygenase-2

Journal of Biological Chemistry

Volumn 285, Issue 29, 2010, Pages 22152-22163

  Vecchio, Alex J ^a,b   Simmons, Danielle M ^a,b   Malkowski, Michael G ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-STRUCTURE; ARACHIDONIC ACIDS; BINDING MODES; BROAD SPECTRUM; CYCLOOXYGENASE 2; CYCLOOXYGENASES; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; FATTY ESTERS; HOMODIMERS; PROTOPORPHYRIN IX; SIDE CHAINS; STRUCTURAL BASIS; SUBSTRATE BINDING;

ACIDS; BINDING ENERGY; CARBOXYLATION; COBALT; CONFORMATIONS; CRYSTAL STRUCTURE; ENVIRONMENTAL PROTECTION AGENCY; ENZYME INHIBITION; ESTERS; FATTY ACIDS; MONOMERS; PORPHYRINS;

SUBSTRATES;

ALANINE; ARACHIDONIC ACID; ARGININE; CARBOXYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; FATTY ACID; HOMODIMER; ICOSAPENTAENOIC ACID; LEUCINE; MONOMER; PHENYLALANINE; PROLINE; PROTOPORPHYRIN COBALT; THREONINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME RECONSTITUTION; ENZYME SUBSTRATE COMPLEX; INSECT CELL; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; ANIMALS; ARACHIDONIC ACID; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FATTY ACIDS; LEUCINE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTANT PROTEINS; OXYGEN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

MURINAE;

EID: 77954611060     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.119867     Document Type: Article

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