Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases

FASEB Journal

Volumn 20, Issue 8, 2006, Pages 1097-1108

  Liu, Wen ^a   Cao, Dazhe ^a   Oh, Sungwhan F ^b   Serhan, Charles N ^b   Kulmacz, Richard J ^a,c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Rice University   (United States)

Author keywords

Aspirin induced lipoxygenase catalysis; Cyclooxygenase activation by peroxide; Cyclooxygenase substrate specificity

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; PEROXIDE; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN H SYNTHETASE 1; PROSTAGLANDIN H SYNTHETASE 2; PROSTAGLANDIN SYNTHASE; PROSTANOID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FISH PROTEIN; PROSTAGLANDIN SYNTHASE INHIBITOR;

ARTICLE; CATALYSIS; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME REGULATION; ENZYME SPECIFICITY; FISH; LIPID COMPOSITION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; HUMAN; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; SHEEP; SPECIES DIFFERENCE; TEMPERATURE; TROUT;

MAMMALIA; SALMONIDAE; SALVELINUS FONTINALIS; VERTEBRATA;

ANIMALS; ARACHIDONIC ACID; ASPIRIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; FISH PROTEINS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; PEROXIDES; SHEEP; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; TEMPERATURE; TROUT;

EID: 33745981772     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5273com     Document Type: Article

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