Structure of Eicosapentaenoic and Linoleic Acids in the Cyclooxygenase Site of Prostaglandin Endoperoxide H Synthase-1

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37547-37555

  Malkowski, Michael G ^b   Thuresson, Elizabeth D ^b   Lakkides, Karen M ^b   Rieke, Caroline Jill ^b   Micielli, Renée ^b   Smith, William L ^a   Garavito, R Michael ^a  

^a Michigan State University   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; FATTY ACIDS; SUBSTITUTION REACTIONS; SUBSTRATES;

OXYGENATION EFFICIENCY;

BIOCHEMISTRY;

ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; FATTY ACID; HYDROGEN; ICOSAPENTAENOIC ACID; LINOLEIC ACID; PHENYLALANINE; POLYUNSATURATED FATTY ACID; PORPHYRIN COBALT; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 1; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 2; PROSTAGLANDIN SYNTHASE; PROTOPORPHYRIN; SERINE; TYROSINE; UNCLASSIFIED DRUG; VALINE; CYCLOOXYGENASE 1; ISOENZYME; LEUCINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING KINETICS; BINDING SITE; COVALENT BOND; CRYSTAL STRUCTURE; DOUBLE BOND; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN INTERACTION; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYME SPECIFICITY; METABOLISM; MUTATION; OXIDATION REDUCTION REACTION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALIA; OVIS;

ARACHIDONIC ACID; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; EICOSAPENTAENOIC ACID; ISOENZYMES; LEUCINE; LINOLEIC ACID; MODELS, MOLECULAR; MUTATION; OXIDATION-REDUCTION; PHENYLALANINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN CONFORMATION; SERINE; SUBSTRATE SPECIFICITY; VALINE;

EID: 0035813182     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105982200     Document Type: Article

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