Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-HETE

Journal of Biological Chemistry

Volumn 275, Issue 9, 2000, Pages 6586-6591

  Rowlinson, Scott W ^a   Crews, Brenda C ^a   Goodwin, Douglas C ^a   Schneider, Claus ^a   Gierse, James K ^b   Marnett, Lawrence J ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; 5 HYDROXYICOSATETRAENOIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2;

AMINO ACID COMPOSITION; ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; ICOSANOID METABOLISM; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ACETYLATION; ANIMALS; ARACHIDONIC ACID; ASPIRIN; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; SPODOPTERA;

MURINAE;

EID: 0034010844     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.9.6586     Document Type: Article

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