Partnering between monomers of cyclooxygenase-2 homodimers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 16, 2006, Pages 6142-6147

  Yuan, Chong ^a   Rieke, Caroline Jill ^a   Rimon, Gilad ^b   Wingerd, Byron A ^a   Smith, William L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Aspirin; Flurbiprofen; Heme ibuprofen; Prostaglandin

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE; ARACHIDONIC ACID; ARGININE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLURBIPROFEN; GLUTAMINE; GLYCINE; HOMODIMER; IBUPROFEN; MONOMER; MUTANT PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 1; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 2; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ARACHIDONIC ACID; BINDING SITES; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DIMERIZATION; FLURBIPROFEN; HUMANS; KINETICS; LIGANDS; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 33646565710     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601805103     Document Type: Article

References (38)

1. Smith, W. L., DeWitt, D. L. & Garavito, R. M. (2000) Annu. Rev. Biochem. 69, 149-182.
2. Rouzer, C. & Marnett, L. (2003) Chem. Rev. (Washington, D.C.) 103, 2239-2304.
3. van der Donk, W., Tsai, A. & Kulmacz, R. (2002) Biochemistry 41, 15451-15458.
4. DeWitt, D. L. (1999) Mol. Pharmacol. 55, 625-631.
5. Prusakiewicz, J., Felts, A., Mackenzie, B. & Marnett, L. (2004) Biochemistry 43, 15439-15445.
6. Xiao, G., Chen, W. & Kulmacz, R. J. (1998) J. Biol. Chem. 273, 6801-6811.
7. Kulmacz, R. J. & Lands, W. E. M. (1985) J. Biol. Chem. 260, 12572-12578.
8. Rosenstock, M., Danon, A. & Rimon, G. (1999) Biochim. Biophys. Acta 1440, 127-137.
9. Rosenstock, M., Danon, A., Rubin, M. & Rimon, G. (2001) Eur. J. Pharmacol. 412, 101-108.
10. Burde, T. & Rimon, G. (2002) Eur. J. Pharmacol. 453, 167-173.
11. Thuresson, E. D., Lakkides, K. M., Rieke, C. J., Sun, Y., Wingerd, B. A., Micielli, R., Mulichak, A. M., Malkowski, M. G., Garavito, R. M. & Smith, W. L. (2001) J. Biol. Chem. 276, 10347-10357.
12. Shimokawa, T. & Smith, W. L. (1992) J. Biol. Chem. 267, 12387-12392.
13. Rowlinson, S. W., Crews, B. C., Lanzo, C. A. & Marnett, L. J. (1999) J. Biol. Chem. 274, 23305-23310.
14. Malkowski, M. G., Thuresson, E. D., Lakkides, K. M., Rieke, C. J., Micielli, R., Smith, W. L. & Garavito, R. M. (2001) J. Biol. Chem. 276, 37547-37555.
15. Thuresson, E. D., Malkowski, M. G., Lakkides, K. M., Rieke, C. J., Mulichak, A. M., Ginell, S. L., Garavito, R. M. & Smith, W. L. (2001) J. Biol. Chem. 276, 10358-10365.
16. Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, M. & Smith, W. L. (1996) J. Biol. Chem. 271, 2179-2184.
17. Malkowski, M. G., Ginell, S., Smith, W. L. & Garavito, R. M. (2000) Science 289, 1933-1937.
18. Rieke, C. J., Mulichak, A. M., Garavito, R. M. & Smith, W. L. (1999) J. Biol. Chem. 274, 17109-17114.
19. Spencer, A. G., Woods, J. W., Arakawa, T., Singer, I. I. & Smith, W. L. (1998) J. Biol. Chem. 273, 9886-9893.
20. Laneuville, O., Breuer, D. K., Xu, N., Huang, Z. H., Gage, D. A., Watson, J. T., Lagarde, M., DeWitt, D. L. & Smith, W. L. (1995) J. Biol. Chem. 270, 19330-19336.
21. Thuresson, E. D., Lakkides, K. M. & Smith, W. L. (2000) J. Biol. Chem. 275, 8501-8507.
22. Song, I., Ball, T. M. & Smith, W. L. (2001) Biochem. Biophys. Res. Commun. 289, 869-875.
23. Laneuville, O., Breuer, D. K., Dewitt, D. L., Hla, T., Funk, C. D. & Smith, W. L. (1994) J. Pharmacol. Exp. Ther. 271, 927-934.
24. Picot, D., Loll, P. J. & Garavito, M. (1994) Nature 367, 243-249.
25. Kurumbail, R. G., Stevens, A. M., Gierse, J. K., McDonald, J. J., Stegeman, R. A., Pak, J. Y., Gildehaus, D., Miyashiro, J. M., Penning, T. D., Seibert, K., et al. (1996) Nature 384, 644-648.
26. Houtzager, V., Ouellet, M., Falgueyret, J., Passmore, L., Bayly, C. & Percival, M. (1996) Biochemistry 35, 10974-10984.
27. Izard, T. & Geerlof, A. (1999) EMBO J. 18, 2021-2030.
28. Hoylaerts, M. F., Manes, T. & Millan, J. L. (1997) J. Biol. Chem. 272, 22781-22787.
29. Klotz, I. M. & Hunston, D. L. (1977) Proc. Natl. Acad. Sci. USA 74, 4959-4963.
30. Sinha, S. C., Wetterer, M., Sprang, S. R., Schultz, J. E. & Linder, J. U. (2005) EMBO J. 24, 663-673.
31. Zhang, W., Olson, J. S. & Phillips, G. N., Jr. (2005) Biophys. J. 88, 2801-2814.
32. Roberts, C. & Chlebowski, J. (1984) J. Biol. Chem. 259, 3625-3632.
33. Bild, G., Janson, C. & Boyer, P. (1980) J. Biol. Chem. 255, 8109-8115.
34. Izard, T. (2003) J. Bacteriol. 185, 4074-4080.
35. Hill, T. L. (1978) Proc. Natl. Acad. Sci. USA 75, 1101-1105.
36. Kalgutkar, A., Crews, B. & Marnett, L. (1996) Biochemistry 35, 9076-9082.
37. Spencer, A. G., Thuresson, E. A., Otto, J. C., Song, I., Smith, T., DeWitt, D. L., Garavito, R. M. & Smith, W. L. (1999) J. Biol. Chem. 274, 32936-32942.
38. Kiefer, J., Pawlitz, J., Moreland, K., Stegeman, R., Hood, W., Gierse, J., Stevens, A., Goodwin, D., Rowlinson, S., Marnett, L., et al. (2000) Nature 405, 97-101.