Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11- hydroperoxyeicosatetraenoic acid

Journal of Biological Chemistry

Volumn 279, Issue 41, 2004, Pages 42929-42935

  Harman, Christine A ^a   Rieke, Caroline Jill ^a,b   Garavito, R Michael ^a   Smith, William L ^a,b  

^a Michigan State University   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COBALT COMPOUNDS; CRYSTAL STRUCTURE; ENZYMES; MUTAGENS;

ARACHIDONIC ACID (AA); DOUBLE MUTANTS;

ORGANIC ACIDS;

11 HYDROPEROXYICOSATETRAENOIC ACID; 15 HYDROPEROXYARACHIDONIC ACID; ARACHIDONIC ACID; ARACHIDONIC ACID DERIVATIVE; COBALT; ENDOPEROXIDE; MUTANT PROTEIN; PEROXY RADICAL; PROSTAGLANDIN G2; PROSTAGLANDIN SYNTHASE; PROTOPORPHYRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; BINDING SITES; CARBON; CATALYSIS; CELL LINE; CHROMATOGRAPHY, THIN LAYER; COBALT; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; DNA, COMPLEMENTARY; INSECTS; ISOENZYMES; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; OLIGONUCLEOTIDES; PEROXIDES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN CONFORMATION; PROTOPORPHYRINS; SHEEP;

ANIMALIA; OVIS;

EID: 5644259546     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403013200     Document Type: Article

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