Mutational and X-ray Crystallographic Analysis of the Interaction of Dihomo-γ-linolenic Acid with Prostaglandin Endoperoxide H Synthases

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10358-10365

  Thuresson, Elizabeth D ^a   Malkowski, Michael G ^a   Lakkides, Karen M ^a   Rieke, Caroline Jill ^a   Mulichak, Anne M ^a   Ginell, Stephen L ^b   Garavito, R Michael ^a   Smith, William L ^a  

^a Institute for Environmental Toxicology   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; FATTY ACIDS; X RAY CRYSTALLOGRAPHY;

OXYGENATION;

ENZYMES;

ARACHIDONIC ACID; DIHOMO GAMMA LINOLENIC ACID; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN ENDOPEROXIDE; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 1; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 2; PROSTAGLANDIN SYNTHASE; SERINE; TYROSINE; UNCLASSIFIED DRUG; VALINE; FATTY ACID; OXYGEN; PEROXIDASE;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; MUTATION; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING SITE; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN CONFORMATION; WESTERN BLOTTING;

ANIMALIA;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; ARACHIDONIC ACID; BINDING SITES; BLOTTING, WESTERN; COS CELLS; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; FATTY ACIDS; KINETICS; MODELS, MOLECULAR; MUTATION; OXYGEN; PEROXIDASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE; SUBSTRATE SPECIFICITY; TRANSFECTION; VALINE;

EID: 0035971186     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009378200     Document Type: Article

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