Identification of Two Cyclooxygenase Active Site Residues, Leucine 384 and Glycine 526, That Control Carbon Ring Cyclization in Prostaglandin Biosynthesis

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 4404-4414

  Schneider, Claus ^a   Boeglin, William E ^a   Brash, Alan R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CARBON; CATALYSIS; CHEMICAL BONDS; ENZYMES; FATTY ACIDS;

CIRCULAR DICHROISM (CD); OXYGENATION;

BIOCHEMISTRY;

CARBON; GLYCINE; LEUCINE; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; CATALYSIS; CIRCULAR DICHROISM; CRYSTALLIZATION; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RESIDUE ANALYSIS; RING OPENING; STEREOCHEMISTRY; X RAY ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ARACHIDONIC ACIDS; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 2; FREE RADICALS; GLYCINE; HELA CELLS; HUMANS; ISOENZYMES; LEUCINE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS G; RECOMBINANT PROTEINS;

ANIMALIA; PERO;

EID: 1042266641     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307431200     Document Type: Article

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