Prostaglandin endoperoxide H synthase-1: The functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10347-10357

  Thuresson, Elizabeth D ^b   Lakkides, Karen M ^b   Rieke, Caroline Jill ^b   Sun, Ying ^b   Wingerd, Byron A ^b   Micielli, Renée ^b   Mulichak, Anne M ^b   Malkowski, Michael G ^b   Garavito, R Michael ^b   Smith, William L ^a  

^a Michigan State University   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSYNTHESIS; CATALYSIS; HYDROPHOBICITY; ORGANIC ACIDS;

MUTATIONAL ANALYSIS;

ENZYMES;

ARACHIDONIC ACID; ARGININE; GLYCINE; PEROXIDASE; PROSTAGLANDIN ENDOPEROXIDE; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 1; PROSTAGLANDIN SYNTHASE; THROMBOXANE; TYROSINE; UNCLASSIFIED DRUG; AMINO ACID; CYCLOOXYGENASE 1; ESTER; HYDROGEN; ISOENZYME; LEUCINE; METHIONINE; OXYGEN; PHENYLALANINE; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; CATALYSIS; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MEMBRANE BINDING; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN DOMAIN; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL MEMBRANE; CELL STRAIN COS1; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SHEEP; THIN LAYER CHROMATOGRAPHY; TIME; WESTERN BLOTTING;

ANIMALIA; OVIS;

AMINO ACIDS; ANIMALS; ARACHIDONIC ACID; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; COS CELLS; CYCLOOXYGENASE 1; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTERS; HYDROGEN; ISOENZYMES; KINETICS; LEUCINE; METHIONINE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; OXYGEN; PEROXIDASE; PHENYLALANINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SHEEP; TIME FACTORS; TRANSFECTION; TRYPTOPHAN;

EID: 0035971116     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009377200     Document Type: Article

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