The role of arginine 120 of human prostaglandin endoperoxide H synthase- 2 in the interaction with fatty acid substrates and inhibitors

Journal of Biological Chemistry

Volumn 274, Issue 24, 1999, Pages 17109-17114

  Rieke, Caroline Jill ^a   Mulichak, Anne M ^a   Garavito, R Michael ^a   Smith, William L ^a  

^a Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ARACHIDONIC ACID; ARGININE; ENZYME INHIBITOR; FATTY ACID; FLURBIPROFEN; ISOENZYME; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN SYNTHASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ARACHIDONIC ACID; ARGININE; CATALYTIC DOMAIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FATTY ACIDS; HUMANS; HYDROXY ACIDS; ISOENZYMES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0033546297     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.24.17109     Document Type: Article

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