Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP

Journal of Neurochemistry

Volumn 114, Issue 3, 2010, Pages 832-842

  Hughes, Mary ^a   Snetkov, Vladimir ^a   Rose, Ruth Sarah ^a   Trousil, Sebastian ^a   Mermoud, Jacqueline E ^b   Dingwall, Colin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

adhesion; amyloid precursor protein; cerulenin; mevalonate; statins

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMYLOID PRECURSOR PROTEIN; CERULETIDE; GAMMA SECRETASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; SIMVASTATIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL STRUCTURE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DEMENTIA; ENZYME ACTIVITY; IMAGING; MUTATION; NERVE FIBER GROWTH; NEURITE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; CELL SHAPE; DRUG EFFECTS; HUMAN; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEUROBLASTOMA; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE; VIDEO MICROSCOPY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; CELL ADHESION; CELL LINE, TUMOR; CELL SHAPE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MICROSCOPY, VIDEO; NEURITES; NEUROBLASTOMA; NEUROGENESIS;

EID: 77954322619     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06811.x     Document Type: Article

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