The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons

Journal of Neurochemistry

Volumn 97, Issue 3, 2006, Pages 716-723

  Pooler, Amy M ^a   Xi, Shijun C ^a   Wurtman, Richard J ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase; Cholesterol; Isoprenylation; Neuritogenesis; Rho; Statin

Indexed keywords

CHOLESTEROL; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEMBRANE PHOSPHOLIPID; MEVALONIC ACID; PHOSPHATIDYLCHOLINE; PRAVASTATIN; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HIPPOCAMPUS; INCUBATION TIME; ISOPRENYLATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; ANIMALS, NEWBORN; BETA-CYCLODEXTRINS; BLOTTING, WESTERN; CELL FRACTIONATION; CELLS, CULTURED; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; HIPPOCAMPUS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUCINE; METHIONINE; NEURITES; NEURONS; PHOSPHOLIPIDS; PRAVASTATIN; RATS; RHOA GTP-BINDING PROTEIN; TIME FACTORS;

ANIMALIA;

EID: 33645854917     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03763.x     Document Type: Article

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