HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis

Journal of Neurochemistry

Volumn 89, Issue 1, 2004, Pages 24-32

  Schulz, Joachim G ^a,b   Bösel, Julian ^a   Stoeckel, Magali ^a   Megow, Dirk ^a   Dirnagl, Ulrich ^a   Endres, Matthias ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b CB2 ^*  (Belgium)

Author keywords

Cholesterol; Geranylgeranylpyrophosphate; Hydroxymethylglutaryl coenzyme A reductase; Neurite outgrowth; PC12 cells

Indexed keywords

ATORVASTATIN; CHOLESTEROL; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; NERVE GROWTH FACTOR; SQUALENE;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL DEATH; CELL DIFFERENTIATION; CELL LOSS; CELL STRAIN; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; EMBRYO; ENZYME INHIBITION; ISOPRENYLATION; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 1842510494     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02305.x     Document Type: Article

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