Metabotropic glutamate mGlu1 receptor stimulation and blockade: Therapeutic opportunities in psychiatric illness

European Journal of Pharmacology

Volumn 639, Issue 1-3, 2010, Pages 2-16

  Lesage, Anne ^a   Steckler, Thomas ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Anxiety; Depression; Metabotropic glutamate mGlu1 receptor; Negative allosteric modulator; Positive allosteric modulator; Schizophrenia

Indexed keywords

(3A,6A) 6A NAPHTALEN 2 YLMETHYL 5 METHYLIDEN HEXAHYDROCYCLOPENTA[C]FURAN 1 ON; 1 (3,4 DIHYDRO 2H PYRANO[2,3 B]QUINOLIN 7 YL) 2 PHENYL 1 ETHANONE; 1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 3 ETHYL QUINOLIN 6 YL CIS 4 METHOXYCYCLOHEXYL KETONE; 2 CYCLOPROPYL 5 [1 (2 FLUORO 3 PYRIDINYL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] 2,3 DIHYDRO 1H ISOINDOL 1 ONE; 3 ETHYL 2 METHYLQUINOLIN 6 YL CIS 4 METHOXYCYCLOHEXYL KETONE; 3,4 DIHYDRO 2H PYRANO[2,3]B QUINOLIN 7 YL CIS 4 METHOXYCYCLOHEXYL KETONE; 4 [1 (2 FLUOROPYRIDINE 3 YL) 5 METHYL 1H 1,2,3 TRIAZOL 4 YL] N ISOPROPYL N METHYL 3,6 DIHYDROPYRIDINE 1(2H)CARBOXAMIDE; 4 AMINOBUTYRIC ACID; 4 CARBOXY 2 METHYLPHENYLGLYCINE; 4 METHOXYPHENYL (6 METHOXY QUINAZOLIN 4 YL)AMINE; 6 AMINO N CYCLOHEXYL N,3 DIMETHYLTHIAZOLO[3,2 A]BENZIMIDAZOLE 2 CARBOXAMIDE; 7 HYDROXYIMINOCYCLOPROPAN[B]CHROMEN 1A CARBOXYLIC ACID ETHYL ESTER; 9 DIMETHYLAMINO 3 (N HEXAMETHYLENEIMINYL) 3H 5 THIA 1,3,6 TRIAZAFLUOREN 4 ONE; CHLORDIAZEPOXIDE; DIAZEPAM; IMIPRAMINE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; RO 016128; RO 0711401; RO 674853; RO 677476; UNCLASSIFIED DRUG; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; PSYCHOTROPIC AGENT;

ANTICONVULSANT ACTIVITY; ANXIETY DISORDER; AVERSIVE BEHAVIOR; COGNITION; COGNITIVE DEFECT; DEPRESSION; DOPAMINE RELEASE; DRUG DEPENDENCE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERANCE; HUMAN; KNOCKOUT MOUSE; LEARNING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR DISORDER; REINFORCEMENT; REVIEW; SCHIZOPHRENIA; SIDE EFFECT; TRANQUILIZING ACTIVITY; WORKING MEMORY; ALLOSTERISM; ANIMAL; DRUG ANTAGONISM; DRUG TOXICITY; METABOLISM; PHYSIOLOGY;

ALLOSTERIC REGULATION; ANIMALS; DRUG TOXICITY; HUMANS; PSYCHOTROPIC DRUGS; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA;

EID: 77953615183     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.12.043     Document Type: Review

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