mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C

Neuropharmacology

Volumn 40, Issue 7, 2001, Pages 856-865

  Skeberdis, Vytenis A ^a   Lan, Jian Yu ^a   Opitz, Thoralf ^a,b   Zheng, Xin ^a   Bennett, Michael V L ^a   Suzanne Zukin, R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

(1S,3R) ACPD; Metabotropic glutamate receptors; N Methyl D aspartate receptors; Phospholipase C; Protein kinase C; Xenopus oocytes

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; ACTIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; CYTOCHALASIN D; ENZYME INHIBITOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR TYPE 1; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; STAUROSPORINE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CHLORIDE CURRENT; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; NERVE CELL PLASTICITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; XENOPUS LAEVIS;

ANIMALS; CALCIUM; CYCLOLEUCINE; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FEMALE; MICE; PROTEIN KINASE C; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; TETRADECANOYLPHORBOL ACETATE; XENOPUS LAEVIS;

EID: 0034985915     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00005-3     Document Type: Article

References (43)

1. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
2. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: Differential attachment of NMDA versus AMPA receptors
3. Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C
4. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells
5. The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
6. Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex
7. Metabotropic glutamate receptors modulate NMDA receptor function in neostriatal neurons
8. Pharmacology and function of metabotropic glutamate receptors
9. Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C
10. Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors
11. Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices
12. Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation
13. Multiple effects of phorbol esters in the rat spinal dorsal horn
14. Diversity and selectivity of receptor-G protein interaction
15. Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices
16. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: Comparison with mGluR1
17. Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes
18. Protein kinase C modulates NMDA receptor trafficking and gating
19. Activation of the metabotropic glutamate receptor accelerates NMDA receptor trafficking
20. Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
21. Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites
22. Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current
23. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
24. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites
25. Potentiation of a metabotropoic glutamatergic response following NMDA receptor activation in rat hippocampus
26. The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and cytoskeleton
27. Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection
28. A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1 alpha metabotropic glutamate receptors
29. The metabotropic glutamate receptors: Structure and functions
30. Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones
31. Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development
32. The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus
33. Calcium-induced actin depolymerization reduces NMDA channel activity
34. Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes
35. A pharmacological characterization of the mGluR1a subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line
36. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
37. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
38. Protein kinase C potentiation of currents from mouse ζ1/ε2 NMDA receptors expressed in Xenopus oocytes depends on f-actin/g-actin cycling
39. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C
40. Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons
41. 2+ influx amplifies protein kinase C potentiation of recombinant NMDA receptors
42. Protein kinase C potentiation of N-methyl-D-aspartate receptor activity is not mediated by phosphorylation of N-methyl-D-aspartate receptor subunits
43. Potentiation of recombinant NR1/NR2 NMDA receptors by activation of mGluR1: Molecular mechanism of action