Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia

Synapse

Volumn 57, Issue 3, 2005, Pages 123-131

  Gupta, Daya S ^a   McCullumsmith, Robert E ^a,c   Beneyto, Monica ^a   Haroutunian, Vahram ^b   Davis, Kenneth L ^b   Meador Woodruff, James H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Human; Immunoreactivity; mGluR; Neuroanatomy; Postmortem brain; Western blot

Indexed keywords

METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1A; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 4A; METABOTROPIC RECEPTOR 5; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CAUDATE NUCLEUS; CLINICAL ARTICLE; CORPUS STRIATUM; FEMALE; HUMAN; IMMUNOREACTIVITY; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NUCLEUS ACCUMBENS; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUTAMEN; SCHIZOPHRENIA; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CORPUS STRIATUM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; POSTMORTEM CHANGES; PREFRONTAL CORTEX; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA;

EID: 22544449233     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.20164     Document Type: Article

References (52)

1. Aparicio-Legarza MI, Davis B, Hutson PH, Reynolds GP. 1998. Increased density of glutamate/N-methyl-D-aspartate receptors in putamen from schizophrenic patients. Neurosci Lett 241:143-146.
2. Aronica E, van Vliet EA, Mayboroda OA, Troost D, da Silva FH, Gorter JA. 2000. Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy. Eur J Neurosci 12:2333-2344.
3. Aronica E, Gorter JA, Ijlst-Keizers H, Rozemuller AJ, Yankaya B, Leenstra S, Troost D. 2003. Expression and functional role of mGluR3 and mGluRS in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Eur J Neurosci 17:2106-2118.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Bradley SR, Standaert DG, Levey AI, Conn PJ. 1999a. Distribution of group III mGluRs in rat basal ganglia with subtype-specific antibodies. Ann N Y Acad Sci 868:531-534.
6. Bradley SR, Standaert DG, Rhodes KJ, Rees HD, Testa CM, Levey AI, Conn PJ. 1999b. Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia. J Comp Neurol 407:33-46.
7. Braff DL, Geyer MA. 1990. Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 47:181-188.
8. Bunney WE, Bunney BG. 2000. Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia. Brain Res Brain Res Rev 31:138-146.
9. Cauli B, Porter JT, Tsuzuki K, Lambolez B, Rossier J, Quenet B, Audinat E. 2000. Classification of fusiform neocortical interneurons based on unsupervised clustering. Proc Natl Acad Sci USA 97:6144-6149.
10. Chen Q, He G, Wu S, Xu Y, Feng G, Li Y, Wang L, He L. 2005. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. Schizophr Res 73:21-26.
11. Chowdari KV, Mirnics K, Semwal P, Wood J, Lawrence E, Bhatia T, Deshpande SN, Ferrell RE, Middleton FA, Devlin B, Levitt P, Lewis DA, Nimgaonkar VL. 2002. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum Mol Genet 11:1373-1380.
12. Clinton SM, Meador-Woodruff JH. 2004. Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities. Schizophr Res 69:237-253.
13. Clinton SM, Haroutunian V, Davis KL, Meador-Woodruff JH. 2003. Altered transcript expression of NMDA receptor-associated post-synaptic proteins in the thalamus of subjects with schizophrenia. Am J Psychiatry 160:1100-1109.
14. Conn PJ, Pin JP. 1997. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205-237.
15. Crook JM, Akil M, Law BC, Hyde TM, Kleinman JE. 2002. Comparative analysis of group II metabotropic glutamate receptor immunoreactivity in Brodmann's area 46 of the dorsolateral prefrontal cortex from patients with schizophrenia and normal subjects. Mol Psychiatry 7:157-164.
16. Dean B, Hussain T. 2001. Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia. Schizophr Res 52:107-114.
17. Devon RS, Anderson S, Teague PW, Muir WJ, Murray V, Pelosi AJ, Blackwood DH, Porteous DJ. 2001. The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia. Mol Psychiatry 6:311-314.
18. Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. 2004. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A 101:12604-12609.
19. Fujii Y, Shibata H, Kikuta R, Makino C, Tani A, Hirata N, Shibata A, Ninomiya H, Tashiro N, Fukumaki Y. 2003. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. Psychiatr Genet 13:71-76.
20. Gill SS, Pulido OM, Mueller RW, McGuire PF. 1999. Immunochemical localization of the metabotropic glutamate receptors in the rat heart. Brain Res Bull 48:143-146.
21. Goff DC, Coyle JT. 2001. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 158:1367-1377.
22. Healy DJ, Haroutunian V, Powchik P, Davidson M, Davis KL, Watson SJ, Meador-Woodruff JH. 1998. AMPA receptor binding and subunit mRNA expression in prefrontal cortex and striatum of elderly schizophrenics. Neuropsychopharmacology 19:278-286.
23. Hsiao MC, Lin KJ, Liu CY, Tzen KY, Yen TC. 2003. Dopamine transporter change in drug-naive schizophrenia: an imaging study with 99mTc-TRODAT-1. Schizophr Res 65:39-46.
24. Hubert GW, Paquet M, Smith Y 2001. Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey substantia nigra. J Neurosci 21:1838-1847.
25. Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG. 2000. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci 3:661-669.
26. Kegeles LS, Shungu DC, Anjilvel S, Chan S, Ellis SP, Xanthopoulos E, Malaspina D, Gorman JM, Mann JJ, Laruelle M, Kaufmann CA. 2000. Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies. Psychiatry Res 98:163-175.
27. Kosinski CM, Risso Bradley S, Conn PJ, Levey AI, Landwehrmeyer GB, Penney JrJB, Young AB, Standaert DG. 1999. Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia. J Comp Neurol 415:266-284.
28. Mateos JM, Benâitez R, Elezgarai I, Azkue JJ, Lâazaro E, Osorio A, Bilbao A, Doänate F, Sarrâia R, Conquet F, Ferraguti F, Kuhn R, Knèopfel T, Grandes P. 2000. Immunolocalization of the mGluR1b splice variant of the metabotropic glutamate receptor 1 at parallel fiber-Purkinje cell synapses in the rat cerebellar cortex. J Neurochem 74:1301-1309.
29. McCullumsmith RE, Meador-Woodruff JH. 2002. Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder. Neuropsychopharmacology 26:368-375.
30. Meador-Woodruff JH, Healy DJ. 2000. Glutamate receptor expression in schizophrenic brain. Brain Res Brain Res Rev 31:288-294.
31. Meador-Woodruff JH, Damask SP, Wang J, Haroutunian V, Davis KL, Watson SJ. 1996. Dopamine receptor mRNA expression in human striatum and neocortex. Neuropsychopharmacology 15:17-29.
32. Meador-Woodruff JH, Haroutunian V, Powchik P, Davidson M, Davis KL, Watson SJ. 1997. Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia. Arch Gen Psychiatry 54:1089-1095.
33. Meador-Woodruff JH, Davis KL, Haroutunian V, Mental Health Research I. 2001a. Abnormal kainate receptor expression in prefrontal cortex in schizophrenia. Neuropsychopharmacology 24:545-552.
34. Meador-Woodruff JH, Hogg AJ, Smith RE. 2001b. Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder. Brain Res Bull 55:631-640.
35. Meador-Woodruff JH, Clinton SM, Beneyto M, McCullumsmith RE. 2003. Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia. Ann N Y Acad Sci 1003:75-93.
36. Mueller HT, Meador-Woodruff JH. 2004. NR3A NMDA receptor sub-unit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophrenia Res 71:361-370.
37. Mueller HT, Haroutunian V, Davis KL, Meador-Woodruff JH. 2004. Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia. Brain Res Mol Brain Res 121:60-69.
38. Muly EC, Maddox M, Smith Y. 2003. Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex. J Comp Neurol 467:521-535.
39. Nakanishi S. 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
40. Nakanishi S. 1994. Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron 13:1031-1037.
41. Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, Watanabe D, Yamaguchi S, Kawabata S, Okada M. 1998. Glutamate receptors: brain function and signal transduction. Brain Res Brain Res Rev 26:230-235.
42. Noga JT, Hyde TM, Herman MM, Spurney CF, Bigelow LB, Weinberger DR, Kleinman JE. 1997. Glutamate receptors in the post-mortem striatum of schizophrenic, suicide, and control brains. Synapse 27:168-176.
43. Ohnuma T, Augood SJ, Arai H, McKenna PJ, Emson PC. 1998. Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia. Brain Res Mol Brain Res 56:207-217.
44. Ohnuma T, Tessler S, Arai H, Faull RL, McKenna PJ, Emson PC. 2000. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Brain Res Mol Brain Res 85:24-31.
45. Perl DP, Good PF, Bussiáere T, Morrison JH, Erwin JM, Hof PR. 2000. Practical approaches to stereology in the setting of aging-and disease-related brain banks. J Chem Neuroanat 20:7-19.
46. Petralia RS, Wang YX, Niedzielski AS, Wenthold RJ. 1996. The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience 71:949-976.
47. Pin JP, Duvoisin R. 1995. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34:1-26.
48. Simpson MD, Slater P, Deakin JF. 1998. Comparison of glutamate and gamma-aminobutyric acid uptake binding sites in frontal and temporal lobes in schizophrenia. Biol Psychiatry 44:423-427.
49. Tallaksen-Greene SJ, Kaatz KW, Romano C, Albin RL. 1998. Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons. Brain Res 780:210-217.
50. Tascedda F, Blom JM, Brunello N, Zolin K, Gennarelli M, Colzi A, Bravi D, Carra S, Racagni G, Riva MA. 2001. Modulation of glutamate receptors in response to the novel antipsychotic olanzapine in rats. Biol Psychiatry 50:117-122.
51. Theberge J, Bartha R, Drost DJ, Menon RS, Malla A, Takhar J, Neufeld RW, Rogers J, Pavlosky W, Schaefer B, Densmore M, Al-Semaan Y, Williamson PC. 2002. Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers. Am J Psychiatry 159:1944-1946.
52. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE. 2001. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 50: 825-844.