Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study

Biological Psychiatry

Volumn 47, Issue 4, 2000, Pages 305-313

  Auer, Dorothee P ^a   Pütz, Benno ^a   Kraft, Eduard ^a   Lipinski, Bernadette ^a   Schill, Julia ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Cingulate cortex; Glutamate; Magnetic resonance proton spectroscopy; Major depression; Regional differences

Indexed keywords

CHOLINE DERIVATIVE; CREATINE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; N ACETYLASPARTIC ACID;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEPRESSION; FEMALE; GRAY MATTER; HUMAN; IN VIVO STUDY; MALE; NEUROCHEMISTRY; NEUROTRANSMISSION; PATHOGENESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADULT; AGED; ASPARTIC ACID; CHOLINE; CREATINE; DEPRESSIVE DISORDER, MAJOR; FEMALE; FRONTAL LOBE; GLUTAMIC ACID; GLUTAMINE; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MYO-INOSITOL-1-PHOSPHATE SYNTHASE; SEVERITY OF ILLNESS INDEX;

EID: 0342546475     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00159-6     Document Type: Article

References (38)

1. Altamura C.A., Mauri M.C., Ferrara A., Moro A.R., D'Andrea G., Zamberlan F. Plasma and platelet excitatory amino acids in psychiatric disorders. Am J Psychiatry. 150:1993;1731-1733.
2. Altamura C., Maes M., Dai J., Meltzer H.Y. Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression. Eur Neuropsychopharmacol. 5:(suppl):1995;71-75.
3. Barkai A.I., Dunner D.L., Gross H.A., Mayo P., Fieve R.R. Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biol Psychiatry. 13:1978;65-72.
4. 1H-NMR spectra of human brain. Magn Reson Med. 32:1994;294-302.
5. Bench C.J., Frackowiak R.S., Dolan R.J. Changes in regional cerebral blood flow on recovery from depression. Psychol Med. 25:1995;247-261.
6. 1HMR-spectroscopy in volunteers and patients. Poster presented at the annual meeting of the International Society for Magnetic Resonance in Medicine, Vancouver, Canada.
7. Charles H.C., Lazeyras F., Krishnan K.R., Boyko O.B., Payne M., Moore D. Brain choline in depression in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy . Prog Neuropsychopharmacol Biol Psychiatry. 18:1994;1121-1127.
8. Coffey C.E., Wilkinson W.E., Weiner R.D., Parashos I.A., Djang W.T., Webb M.C., et al. Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry. 50:1993;7-16.
9. Cousins J.P., Harper G. Neurobiochemical changes from Taxol/Neupogen chemotherapy for metastatic breast carcinoma corresponds with suicidal depression. Cancer Lett. 110:1996;163-167.
10. 1H-MR spectroscopy in human brain with and without lorazepam. Poster presented at the annual meeting of the International Society for Magnetic Resonance in Medicine, Vancouver, Canada.
11. Ebert D., Ebmeier K.P. The role of the cingulate gyrus in depression - from functional anatomy to neurochemistry. Biol Psychiatry. 39:1996;1044-1050.
12. 2+-dependent release in intractable depression assessed antemortem. Brain Res 494:315-244.
13. Goodwin G.M. Functional imaging, affective disorder and dementia. Br Med Bull. 52:1996;495-512.
14. Hennig J., Thiel T., Speck O. Improved sensitivity to overlapping multiplet signals in in vivo proton spectroscopy using a multiecho volume selective (CPRESS) experiment. Magn Reson Med. 37:1997;816-820.
15. 3H]MK-801, in brain samples from drug-free depressed suicides. Brain Res. 616:1993;138-143.
16. Holsboer F., Lauer C.J., Schreiber W., Krieg J.C. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology. 62:1995;340-347.
17. Hurd R.E., Gurr D., Sailasuta N. Proton spectroscopy without water suppression - the oversampled J-resolved experiment. Magn Reson Med. 40:1998;343-347.
18. Janowsky D.S., Yousef M.K., Davis J.M., Sekerke J.H. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 2:1972;632-635.
19. Janowsky D.S., Overstreet D.H. The role of acetylcholine mechanisms in mood disorders. Bloom F.E., Kupffer D.J. Psychopharmacology The Fourth Generation of Progress . 1995;945-956 Raven Press, New York.
20. Keltner J.R., Wald L.L., Christensen J.D., Maas L.C., Moore C.M., Cohen B.M., et al. A technique for detecting GABA in the human brain with PRESS localization and optimized refocusing spectral editing radiofrequency pulses. Magn Reson Med. 36:1996;458-461.
21. Knörle R., Assmann D., Landwehrmeyer B., Scheremet R., Müller K., Feuerstein J. Aspartate, glutamate, glutamine, glycine and GABA in human bioptic neocortical areas comparison to autoptic tissue . Neurosci Lett. 221:1997;169-172.
22. Larisch R., Klimke A., Vosberg H., Loffler S., Gaebel W., Mullergartner H.W. In vivo evidence for the involvement of dopamine-D-2 receptors in striatum and anterior cingulate gyrus in major depression. Neuroimage. 5:1997;251-260.
23. 1H NMR spectroscopy. Magn Reson Med. 34:1995;253-259.
24. Levine J., Kurtzman L., Rapoport A., Zimmerman J., Bersudsky Y., Shapiro J., et al. CSF inositol does not predict antidepressant response to inositol. J Neural Transm. 103:1996;1457-1462.
25. Levine J. Controlled trials of inositol in psychiatry. Eur Neuropsychopharmacol. 7:1997;147-155.
26. Meltzer H.Y., Lowy M.T. The serotonin hypothesis of depression. Meltzer H.Y. Psychopharmacology The Third Generation of Progress . 1987;513-526 Raven Press, New York.
27. Moats R.A., Watson L., Shonk T., Tokuyama S., Braslau D., Eto R., et al. Added value of automated clinical proton MR spectroscopy of the brain. J Comput Assist Tomogr. 19:1995;480-491.
28. Nowak G., Ordway G.A., Paul I.A. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res. 675:1995;157-164.
29. Pan J.W., Mason G.F., Pohost G.M., Hetherington H.P. Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T. Magn Reson Med. 36:1996;7-12.
30. Paul I.A., Nowak G., Layer R.T., Popik P., Skolnick P. Adaptation of N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. J Pharmacol Exp Ther. 269:1994;95-102.
31. 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain. Epilepsia. 36:1995;457-464.
32. Pouwels P.J.W., Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med. 39:1998;53-60.
33. Provencher S.W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 30:1993;672-679.
34. Renshaw P.F., Lafer B., Babb S.M., Fava M., Stoll A.L., Christensen J.D., et al. Basal ganglia choline levels in depression and response to fluoxetine treatment - an in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry. 41:1997;837-843.
35. Reynolds I.J., Miller R.J. Tricyclic antidepressants block N-methyl-D-aspartate receptors similarities to the action of zinc . Br J Pharmacol. 95:1988;95-102.
36. Schildkraut J.J. The catecholamine hypothesis of affective disorders A review of supporting evidence . Am J Psychiatry. 122:1965;509-522.
37. Sheline Y.I. Hippocampal atrophy in major depression A result of depression-induced neurotoxicity? Mol Psychiatry. 1:1996;298-299.
38. Urenjak J., Williams S.R., Gadian D.G., Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte type 2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem. 29:1992;55-62.